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Gene Review

RND3  -  Rho family GTPase 3

Homo sapiens

Synonyms: ARHE, Protein MemB, RHO8, RHOE, Rho-related GTP-binding protein Rho8, ...
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Disease relevance of RND3


High impact information on RND3


Biological context of RND3

  • A significant increase of RND2 and RND3 protein expression was observed in pregnant relative to nonpregnant myometrium associated with a loss of PPP1R12A phosphorylation [5].
  • Thus, RhoE is anticipated to function by regulating ROCK I signaling to control the balance between cell survival and cell death in response to genotoxic stress [6].
  • As predicted by these substitutions, which impair GTP hydrolysis in Ras, RhoE binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins [7].
  • We investigated the expression of RhoE and its role in cell cycle regulation and apoptosis in the human prostate [1].
  • In addition, apoptotic cell death as measured by a cleavage product of caspase 3 is significantly increased in RhoE-overexpressing cells [1].

Anatomical context of RND3


Associations of RND3 with chemical compounds


Other interactions of RND3


Analytical, diagnostic and therapeutic context of RND3


  1. Small G-protein RhoE is underexpressed in prostate cancer and induces cell cycle arrest and apoptosis. Bektic, J., Pfeil, K., Berger, A.P., Ramoner, R., Pelzer, A., Schäfer, G., Kofler, K., Bartsch, G., Klocker, H. Prostate (2005) [Pubmed]
  2. Function and regulation of Rnd proteins. Chardin, P. Nat. Rev. Mol. Cell Biol. (2006) [Pubmed]
  3. A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. Nobes, C.D., Lauritzen, I., Mattei, M.G., Paris, S., Hall, A., Chardin, P. J. Cell Biol. (1998) [Pubmed]
  4. RhoE inhibits cell cycle progression and Ras-induced transformation. Villalonga, P., Guasch, R.M., Riento, K., Ridley, A.J. Mol. Cell. Biol. (2004) [Pubmed]
  5. Expression of RND proteins in human myometrium. Lartey, J., Gampel, A., Pawade, J., Mellor, H., Bernal, A.L. Biol. Reprod. (2006) [Pubmed]
  6. RhoE Is a Pro-Survival p53 Target Gene that Inhibits ROCK I-Mediated Apoptosis in Response to Genotoxic Stress. Ongusaha, P.P., Kim, H.G., Boswell, S.A., Ridley, A.J., Der, C.J., Dotto, G.P., Kim, Y.B., Aaronson, S.A., Lee, S.W. Curr. Biol. (2006) [Pubmed]
  7. Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Foster, R., Hu, K.Q., Lu, Y., Nolan, K.M., Thissen, J., Settleman, J. Mol. Cell. Biol. (1996) [Pubmed]
  8. Socius is a novel Rnd GTPase-interacting protein involved in disassembly of actin stress fibers. Katoh, H., Harada, A., Mori, K., Negishi, M. Mol. Cell. Biol. (2002) [Pubmed]
  9. Rnd3/RhoE induces tight junction formation in mammary epithelial tumor cells. Rubenstein, N.M., Chan, J.F., Kim, J.Y., Hansen, S.H., Firestone, G.L. Exp. Cell Res. (2005) [Pubmed]
  10. Selective glucocorticoid control of Rho kinase isoforms regulate cell-cell interactions. Rubenstein, N.M., Callahan, J.A., Lo, D.H., Firestone, G.L. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  11. Identification of genes involved in estrogenic action in the human prostate using microarray analysis. Bektic, J., Wrulich, O.A., Dobler, G., Kofler, K., Ueberall, F., Culig, Z., Bartsch, G., Klocker, H. Genomics (2004) [Pubmed]
  12. Function and regulation of RhoE. Riento, K., Villalonga, P., Garg, R., Ridley, A. Biochem. Soc. Trans. (2005) [Pubmed]
  13. RhoE regulates actin cytoskeleton organization and cell migration. Guasch, R.M., Scambler, P., Jones, G.E., Ridley, A.J. Mol. Cell. Biol. (1998) [Pubmed]
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