Gene Review:
PPP1R12A - protein phosphatase 1, regulatory subunit 12A
Homo sapiens
Synonyms:
M130, MBS, MYPT1, Myosin phosphatase target subunit 1, Myosin phosphatase-targeting subunit 1, ...
- Vascular dysfunction in human and rat cirrhosis: role of receptor-desensitizing and calcium-sensitizing proteins. Hennenberg, M., Trebicka, J., Biecker, E., Schepke, M., Sauerbruch, T., Heller, J. Hepatology (2007)
- Sphingosine 1-phosphate causes airway hyper-reactivity by rho-mediated Myosin phosphatase inactivation. Kume, H., Takeda, N., Oguma, T., Ito, S., Kondo, M., Ito, Y., Shimokata, K. J. Pharmacol. Exp. Ther. (2007)
- Ca2+-desensitizing hypoxic vasorelaxation: pivotal role for the myosin binding subunit of myosin phosphatase (MYPT1) in porcine coronary artery. Wardle, R.L., Gu, M., Ishida, Y., Paul, R.J. J. Physiol. (Lond.) (2006)
- Myosin phosphatase isoform switching in vascular smooth muscle development. Payne, M.C., Zhang, H.Y., Prosdocimo, T., Joyce, K.M., Koga, Y., Ikebe, M., Fisher, S.A. J. Mol. Cell. Cardiol. (2006)
- Optimisation of mammographic breast cancer screening using a computer simulation model. Jansen, J.T., Zoetelief, J. European journal of radiology. (1997)
- Acute dyspnea as perceived by patients with chronic obstructive pulmonary disease. Heinzer, M.M., Bish, C., Detwiler, R. Clinical nursing research. (2003)
- Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha. Surks, H.K., Mochizuki, N., Kasai, Y., Georgescu, S.P., Tang, K.M., Ito, M., Lincoln, T.M., Mendelsohn, M.E. Science (1999)
- Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Kimura, K., Ito, M., Amano, M., Chihara, K., Fukata, Y., Nakafuku, M., Yamamori, B., Feng, J., Nakano, T., Okawa, K., Iwamatsu, A., Kaibuchi, K. Science (1996)
- Lining the pockets of kinases and phosphatases. Gold, M.G., Barford, D., Komander, D. Curr. Opin. Struct. Biol. (2006)
- Phosphoprotein inhibitor CPI-17 specificity depends on allosteric regulation of protein phosphatase-1 by regulatory subunits. Eto, M., Kitazawa, T., Brautigan, D.L. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Evaluation of the new automated enzymun-test anti-HBc plus for the detection of hepatitis B virus core antibody. Weber, B., Michl, U., Mühlbacher, A., Paggi, G., Bossi, V. Intervirology (1998)
- Expression of RND proteins in human myometrium. Lartey, J., Gampel, A., Pawade, J., Mellor, H., Bernal, A.L. Biol. Reprod. (2006)
- Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton. Kiss, E., Murányi, A., Csortos, C., Gergely, P., Ito, M., Hartshorne, D.J., Erdodi, F. Biochem. J. (2002)
- Myosin phosphatase targeting subunit 1 affects cell migration by regulating myosin phosphorylation and actin assembly. Xia, D., Stull, J.T., Kamm, K.E. Exp. Cell Res. (2005)
- Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21. Takahashi, N., Ito, M., Tanaka, J., Nakano, T., Kaibuchi, K., Odai, H., Takemura, K. Genomics (1997)
- Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. Guilluy, C., Sauzeau, V., Rolli-Derkinderen, M., Guérin, P., Sagan, C., Pacaud, P., Loirand, G. Br. J. Pharmacol. (2005)
- Protein kinase C-catalyzed phosphorylation of an inhibitory phosphoprotein of myosin phosphatase is involved in human platelet secretion. Watanabe, Y., Ito, M., Kataoka, Y., Wada, H., Koyama, M., Feng, J., Shiku, H., Nishikawa, M. Blood (2001)
- Agonist- and depolarization-induced signals for myosin light chain phosphorylation and force generation of cultured vascular smooth muscle cells. Woodsome, T.P., Polzin, A., Kitazawa, K., Eto, M., Kitazawa, T. J. Cell. Sci. (2006)
- Ca2+-Independent, Inhibitory Effects of Cyclic Adenosine 5'-Monophosphate on Ca2+ Regulation of Phosphoinositide 3-Kinase C2{alpha}, Rho, and Myosin Phosphatase in Vascular Smooth Muscle. Azam, M.A., Yoshioka, K., Ohkura, S., Takuwa, N., Sugimoto, N., Sato, K., Takuwa, Y. J. Pharmacol. Exp. Ther. (2007)
- Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity. Murányi, A., Zhang, R., Liu, F., Hirano, K., Ito, M., Epstein, H.F., Hartshorne, D.J. FEBS Lett. (2001)
- RhoA- and PKC-alpha-mediated phosphorylation of MYPT and its association with HSP27 in colonic smooth muscle cells. Patil, S.B., Bitar, K.N. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Inhibition of RhoA-mediated SRF activation by p116Rip. Mulder, J., Ariaens, A., van Horck, F.P., Moolenaar, W.H. FEBS Lett. (2005)
- Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle. Wang, Y., Yoshioka, K., Azam, M.A., Takuwa, N., Sakurada, S., Kayaba, Y., Sugimoto, N., Inoki, I., Kimura, T., Kuwaki, T., Takuwa, Y. Biochem. J. (2006)
- PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits. Bannert, N., Vollhardt, K., Asomuddinov, B., Haag, M., König, H., Norley, S., Kurth, R. J. Biol. Chem. (2003)
- Molecular cloning and analysis of the 5'-flanking region of the human MYPT1 gene. Machida, H., Ito, M., Okamoto, R., Shiraki, K., Isaka, N., Hartshorne, D.J., Nakano, T. Biochim. Biophys. Acta (2001)
- Gq/G13 signaling by ET-1 in smooth muscle: MYPT1 phosphorylation via ETA and CPI-17 dephosphorylation via ETB. Hersch, E., Huang, J., Grider, J.R., Murthy, K.S. Am. J. Physiol., Cell Physiol. (2004)
- Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. Wooldridge, A.A., MacDonald, J.A., Erdodi, F., Ma, C., Borman, M.A., Hartshorne, D.J., Haystead, T.A. J. Biol. Chem. (2004)
- Spontaneously tonic smooth muscle has characteristically higher levels of RhoA/ROK compared with the phasic smooth muscle. Patel, C.A., Rattan, S. Am. J. Physiol. Gastrointest. Liver Physiol. (2006)
- Okadaic acid induces phosphorylation and translocation of myosin phosphatase target subunit 1 influencing myosin phosphorylation, stress fiber assembly and cell migration in HepG2 cells. Lontay, B., Kiss, A., Gergely, P., Hartshorne, D.J., Erdodi, F. Cell. Signal. (2005)
- Comparison of psychotropic drug intake in two populations in West Germany. Results from the Munich Blood Pressure Study 1980/81 and the Luebeck Blood Pressure Study 1984. Koenig, W., Rüther, E., Remmers, A., Keil, U. Pharmacopsychiatry (1987)