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Gene Review: 

Mipep  -  mitochondrial intermediate peptidase

Rattus norvegicus

Synonyms: MIP, Mip, Mitochondrial intermediate peptidase
 
 
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Disease relevance of Mipep

 

High impact information on Mipep

  • The first is to a sequence encoding a putative MIP homologue in the recently reported sequence of yeast chromosome III [2].
  • Additional studies on cell contraction and intracellular Ca2+ ([Ca2+]i) revealed that both UP and MIP attenuated the inhibitory effects of severe MI on contractility and electrically induced [Ca2+]i transient in single ventricular myocytes [3].
  • With the use of trypan blue exclusion as an index of cell viability, severe MI killed >60% of the cells and the value increased significantly after MIP [3].
  • Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes [4].
  • Mammalian mitochondrial intermediate peptidase: structure/function analysis of a new homologue from Schizophyllum commune and relationship to thimet oligopeptidases [5].
 

Biological context of Mipep

  • In this study we have investigated how the profiles of the two most abundant fibre cell membrane proteins AQP0 (formerly known as Major Intrinsic Protein, MIP) and MP20 change as a function of fibre cell differentiation [6].
  • In the isolated frog sciatic nerve preparation, IC50 concentrations for nerve block were 0.34 +/- 0.9 mM for lidocaine (LIDO), 0.62 +/- 0.11 mM for procaine, 11.9 +/- 6.1 mM for disopyramide (DIP), and 52.8 +/- 24 mM for MIP (the mono-demethylated metabolite of DIP) [7].
  • PMN were then assayed using DHR for respiratory burst (RB) initiated by sequential MIP-2 and PAF stimulation (MIP/PAF) [8].
 

Anatomical context of Mipep

  • The intracytoplasmatic lipid microvacuoles were quantified in hepatocytes with an image analyzer (software MIP/CID, Spain) [9].
 

Associations of Mipep with chemical compounds

  • The goal of this study was to compare single channel water and glycerol permeabilities of mammalian aquaporins (AQP) 1-5 and the major intrinsic protein of lens fiber (MIP) [4].
  • However, when myocytes were subjected for 30 min to either 20 mM lactate and 10 mM 2-deoxy-d-glucose (MIP) or 30 microM U50,488H (UP) 20 h before MI/A, the changes in viability and injury, and [Ca(2+)](i) responses were significantly attenuated [10].
 

Analytical, diagnostic and therapeutic context of Mipep

References

  1. Rabbit liver microsomal endopeptidase with substrate specificity for processing proproteins is structurally related to rat testes metalloendopeptidase 24.15. Kawabata, S., Nakagawa, K., Muta, T., Iwanaga, S., Davie, E.W. J. Biol. Chem. (1993) [Pubmed]
  2. Sequence analysis of rat mitochondrial intermediate peptidase: similarity to zinc metallopeptidases and to a putative yeast homologue. Isaya, G., Kalousek, F., Rosenberg, L.E. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Cardioprotection of preconditioning by metabolic inhibition in the rat ventricular myocyte. Involvement of kappa-opioid receptor. Wu, S., Li, H.Y., Wong, T.M. Circ. Res. (1999) [Pubmed]
  4. Water and glycerol permeabilities of aquaporins 1-5 and MIP determined quantitatively by expression of epitope-tagged constructs in Xenopus oocytes. Yang, B., Verkman, A.S. J. Biol. Chem. (1997) [Pubmed]
  5. Mammalian mitochondrial intermediate peptidase: structure/function analysis of a new homologue from Schizophyllum commune and relationship to thimet oligopeptidases. Isaya, G., Sakati, W.R., Rollins, R.A., Shen, G.P., Hanson, L.C., Ullrich, R.C., Novotny, C.P. Genomics (1995) [Pubmed]
  6. Insertion of MP20 into lens fibre cell plasma membranes correlates with the formation of an extracellular diffusion barrier. Grey, A.C., Jacobs, M.D., Gonen, T., Kistler, J., Donaldson, P.J. Exp. Eye Res. (2003) [Pubmed]
  7. Local anesthetic activity and disopyramide toxicity. Malavé, A., Holsapple, M.P., Yim, G.K. Archives internationales de pharmacodynamie et de thérapie. (1983) [Pubmed]
  8. Sexual dimorphism in the activation of neutrophils by shock mesenteric lymph. Adams, J.M., Adams, C.A., Xu, D.Z., Fekete, Z., Lu, Q., Livingston, D.H., Deitch, E.A., Hauser, C.J. Surgical infections. (2003) [Pubmed]
  9. Progressive hepatocytic fatty infiltration in rats with prehepatic portal hypertension. Alonso, M.J., Aller, M.A., Corcuera, M.T., Nava, M.P., Gömez, F., Angulo, A., Arias, J. Hepatogastroenterology (2005) [Pubmed]
  10. Effects of heat shock protein 70 activation by metabolic inhibition preconditioning or kappa-opioid receptor stimulation on Ca2+ homeostasis in rat ventricular myocytes subjected to ischemic insults. Liu, J., Kam, K.W., Zhou, J.J., Yan, W.Y., Chen, M., Wu, S., Wong, T.M. J. Pharmacol. Exp. Ther. (2004) [Pubmed]
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