Disease relevance of MIPEP

• This work provides the basis for molecular analysis of MIPEP in FRDA and possibly other neurodegenerative diseases [1].
• MATERIALS AND METHODS: The CA 19-9 content was determined on gangliosidic extracts of human colorectal tumor cells (GEO, WiDr, DLD-1, MIP) in comparison with the degree of TCIPA [2].
• Tumour derived MIP-alpha may also affect the interaction between lung cancer and host inflammatory cells [3].
• Increased MIP expression has been observed in models of bacterial sepsis, silicosis, and oxidant-induced lung injury [4].
• Kaposi's sarcoma (KS)-associated herpes virus 8 encodes for three chemokine-like proteins that show homology with MIP cluster of CC chemokines [5].

High impact information on MIPEP

• Mitochondrial intermediate peptidase and the yeast frataxin homolog together maintain mitochondrial iron homeostasis in Saccharomyces cerevisiae [6].
• Treatment with recombinant human gamma-interferon induced the expression of HLA-DR in the GEO, WiDr, and DLD-1 cells, whereas the MIP cell line remained HLA-DR negative [7].
• Human colorectal cells (GEO, WiDr, DLD-1, and MIP) that lack the constitutive expression of HLA-DR cause platelet aggregation through a thrombin-dependent mechanism [7].
• Further, when the OTC octapeptide is joined to the mature amino terminus of another twice-cleaved precursor (pFe/S; rat malate dehydrogenase, pMDH), the chimeric intermediate is cleaved by MIP to the corresponding mature-sized protein [8].
• There are two major categories of MIP channels, aquaporins and glycerol facilitators, which facilitate the diffusion across biological membranes of water or glycerol and other uncharged compounds, respectively [9].

Biological context of MIPEP

• The MIPEP gene spans 57 kb and consists of 19 exons that correlate with the functional domains of HMIP [1].
• Primer extension analysis has identified a major transcript of the MIPEP gene expressed differentially and predominantly in tissues with high oxygen consumption, while sequence analysis of approximately 2 kb of 5'-flanking DNA has revealed putative Mt1/3/4, NF-kappaB, and AP-1 elements that may regulate MIPEP expression in these tissues [1].
• The mitochondrial intermediate peptidase of Saccharomyces cerevisiae (YMIP) is a component of the yeast mitochondrial protein import machinery critically involved in the biogenesis of the oxidative phosphorylation (OXPHOS) system [10].
• As a result of their involvement in osmoregulation and metabolism, MIP channels are believed to affect a wide range of biological processes [9].
• We found that the LEP503, MIP and Filensin promoters induced strong lens-specific expression of a reporter gene, in human lens cells [11].

Anatomical context of MIPEP

• Northern analysis showed that the MIPEP gene is differentially expressed in human tissues, with the highest levels of expression in the heart, skeletal muscle, and pancreas, three organ systems that are frequently affected in OXPHOS disorders [10].

Associations of MIPEP with chemical compounds

• Coronal images were post-processed with the MIP algorithm [12].
• The pab-1 gene, required for para-aminobenzoic acid synthesis, is found 39 kb upstream of mip [13].
• METHODS: We evaluated four commercially available bare metal and polymer coated drug eluting stents using 64 and 16 detector MSCT for the following: (1) Strut density in Hounsfield's Units (Hu) using a 2 mm MIP; (2) In-stent luminal diameter (ISLD) measured by MSCT compared to intravascular ultrasound (IVUS) [14].
• Methyl mercury was determined by gas chromatography, microwave induced plasma, atomic emission spectrometry (GC-MIP-AES) using two different methods [15].
• Given that the SW voltammetric analysis could not be directly performed in the sample extract as a consequence of interference from some sample components, a sample clean-up with a MIP for selectively retaining fenbendazole was performed [16].

Other interactions of MIPEP

• MRS2L, YME1L and MIPEP have been sequenced in three patients with a combined defect of complexes III and IV [17].
• Functional and genomic analysis of the human mitochondrial intermediate peptidase, a putative protein partner of frataxin [1].

Analytical, diagnostic and therapeutic context of MIPEP

• Using fluorescence in situ hybridization, the MIPEP locus was assigned to 13q12 [10].
• METHODS: Secretion of chemokines (interleukin [IL]-8, monocyte chemoattractant protein [MCP]-1, RANTES, and MIP [macrophage inflammatory protein]-1alpha) was evaluated by ELISA, Northern blotting, and nuclear run-on assays [18].
• A total of 305 patients with no prior chemotherapy were randomized, including 297 patients assessable for survival (147 in the MIP arm and 150 in the CarboMIP arm) and 268 patients assessable for response to chemotherapy [19].
• In this study, the cosegregation of MIP and the A mating-type locus was studied by genotyping progeny of seven additional mushroom species using PCR and genetic crosses [20].
• METHODS: Routine spirometry and arterial blood gases, maximal inspiratory and expiratory muscle pressures (MIP and MEP, respectively), and pleural pressure during maximal sniff test (Pplsn), were measured [21].

References