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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

BAS1  -  cytochrome P450 734A1

Arabidopsis thaliana

Synonyms: CYP72B1, CYP734A1, F18A8.8, F18A8_8, PHYB ACTIVATION TAGGED SUPPRESSOR 1
 
 
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High impact information on BAS1

  • An Arabidopsis thaliana knockout mutant for NTRC shows irregular mesophyll cell shape, abnormal chloroplast structure, and unbalanced BAS1 redox state, resulting in impaired photosynthesis rate under low light [1].
  • Using a CDSP32 active-site mutant, we showed that the BAS1 and CDSP32 proteins form a mixed disulfide complex in vitro [2].
  • We investigated whether the plastidic protein BAS1, which is related to eubacterial 2-Cys peroxiredoxin, is a target for CDSP32 [2].
  • We conclude that CDSP32 is a thioredoxin with a critical role in plastid defense against oxidative damage and that this role is related to its function as a physiological electron donor to the BAS1 peroxiredoxin [2].
  • Thus, BAS1 represents one of the control points between multiple photoreceptor systems and brassinosteroid signal transduction [3].
 

Biological context of BAS1

  • BAS1 and SOB7 act redundantly with respect to light promotion of cotyledon expansion, repression of hypocotyl elongation and flowering time in addition to other phenotypes not regulated by light [4].
  • These P450s show high homology with Arabidopsis CYP734A1/BAS1 (formerly CYP72B1), which inactivates BRs via C-26 hydroxylation [5].
  • CYP72B1 translational fusions with the beta-glucuronidase reporter gene demonstrated that protein levels increased in the hypocotyl elongation zone when shifted from the dark to far-red light, but not blue or red light [6].
 

Associations of BAS1 with chemical compounds

  • Overexpression of SOB7 results in a dramatic reduction in endogenous CS levels, and although single null-mutants of BAS1 and SOB7 have the same level of CS as the wild type, the double null-mutant has twice the amount [4].
  • The basis for the mutant phenotype is the enhanced expression of a cytochrome P450 (CYP72B1). bas1-D suppresses a phyB-null allele, but not a phyA-null mutation, and partially suppresses a cryptochrome-null mutation [3].
  • CYP72B1 inactivates brassinosteroid hormones: an intersection between photomorphogenesis and plant steroid signal transduction [6].
 

Analytical, diagnostic and therapeutic context of BAS1

References

  1. Rice NTRC Is a High-Efficiency Redox System for Chloroplast Protection against Oxidative Damage. Pérez-Ruiz, J.M., Spínola, M.C., Kirchsteiger, K., Moreno, J., Sahrawy, M., Cejudo, F.J. Plant Cell (2006) [Pubmed]
  2. The plastidic 2-cysteine peroxiredoxin is a target for a thioredoxin involved in the protection of the photosynthetic apparatus against oxidative damage. Broin, M., Cuiné, S., Eymery, F., Rey, P. Plant Cell (2002) [Pubmed]
  3. BAS1: A gene regulating brassinosteroid levels and light responsiveness in Arabidopsis. Neff, M.M., Nguyen, S.M., Malancharuvil, E.J., Fujioka, S., Noguchi, T., Seto, H., Tsubuki, M., Honda, T., Takatsuto, S., Yoshida, S., Chory, J. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. BAS1 and SOB7 act redundantly to modulate Arabidopsis photomorphogenesis via unique brassinosteroid inactivation mechanisms. Turk, E.M., Fujioka, S., Seto, H., Shimada, Y., Takatsuto, S., Yoshida, S., Wang, H., Torres, Q.I., Ward, J.M., Murthy, G., Zhang, J., Walker, J.C., Neff, M.M. Plant J. (2005) [Pubmed]
  5. Tomato cytochrome P450 CYP734A7 functions in brassinosteroid catabolism. Ohnishi, T., Nomura, T., Watanabe, B., Ohta, D., Yokota, T., Miyagawa, H., Sakata, K., Mizutani, M. Phytochemistry (2006) [Pubmed]
  6. CYP72B1 inactivates brassinosteroid hormones: an intersection between photomorphogenesis and plant steroid signal transduction. Turk, E.M., Fujioka, S., Seto, H., Shimada, Y., Takatsuto, S., Yoshida, S., Denzel, M.A., Torres, Q.I., Neff, M.M. Plant Physiol. (2003) [Pubmed]
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