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Gene Review

CYP4F12  -  cytochrome P450, family 4, subfamily F,...

Homo sapiens

Synonyms: CYPIVF12, Cytochrome P450 4F12, F22329_1, UNQ568/PRO1129
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Disease relevance of CYP4F12


High impact information on CYP4F12


Biological context of CYP4F12


Anatomical context of CYP4F12


Associations of CYP4F12 with chemical compounds

  • 1. CYP4F12, expressed in yeast, oxidized arachidonic acid to 18-hydroxyarachidonic acid, and the omega-side chain of two stable prostaglandin (PG) H(2) analogs (11,9-epoxymethano-PGH(2) and 9,11-diazo-15-deoxy-PGH(2)) [5].
  • CYP4F enzymes with omega-hydroxylase activity contain a heme-binding Glu residue, whereas CYP4F8 (and CYP4F12) with omega2- and omega 3-hydroxylase activities has a Gly residue in this position of SRS-4 [8].

Other interactions of CYP4F12


Analytical, diagnostic and therapeutic context of CYP4F12

  • Northern blot analysis suggested three major transcripts of CYP4F12, which were detected in liver, kidney, colon, small intestine and heart [5].
  • An antipeptide polyclonal antibody was raised against the C-terminal of CYP4F12 (PLNVGLQ), evaluated by Western blot analysis and used for immunohistological analysis of 50 human tissues [6].


  1. Human CYP4F12 genetic polymorphism: identification and functional characterization of seven variant allozymes. Cauffiez, C., Klinzig, F., Rat, E., Tournel, G., Allorge, D., Chevalier, D., Pottier, N., Lovecchio, T., Colombel, J.F., Lhermitte, M., Lo-Guidice, J.M., Broly, F. Biochem. Pharmacol. (2004) [Pubmed]
  2. Functional characterization of genetic polymorphisms identified in the human cytochrome P450 4F12 (CYP4F12) promoter region. Cauffiez, C., Klinzig, F., Rat, E., Tournel, G., Allorge, D., Chevalier, D., Lovecchio, T., Pottier, N., Colombel, J.F., Lhermitte, M., D'Halluin, J.C., Broly, F., Lo-Guidice, J.M. Biochem. Pharmacol. (2004) [Pubmed]
  3. Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes. Hashizume, T., Imaoka, S., Mise, M., Terauchi, Y., Fujii, T., Miyazaki, H., Kamataki, T., Funae, Y. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  4. cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine. Hashizume, T., Imaoka, S., Hiroi, T., Terauchi, Y., Fujii, T., Miyazaki, H., Kamataki, T., Funae, Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  5. cDna cloning and expression of CYP4F12, a novel human cytochrome P450. Bylund, J., Bylund, M., Oliw, E.H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  6. Expression of CYP4F12 in gastrointestinal and urogenital epithelia. Stark, K., Schauer, L., Sahlén, G.E., Ronquist, G., Oliw, E.H. Basic & clinical pharmacology & toxicology. (2004) [Pubmed]
  7. Expression and induction of CYP4F subfamily in human leukocytes and HL60 cells. Kikuta, Y., Yamashita, Y., Kashiwagi, S., Tani, K., Okada, K., Nakata, K. Biochim. Biophys. Acta (2004) [Pubmed]
  8. Oxygenation of polyunsaturated long chain fatty acids by recombinant CYP4F8 and CYP4F12 and catalytic importance of Tyr-125 and Gly-328 of CYP4F8. Stark, K., Wongsud, B., Burman, R., Oliw, E.H. Arch. Biochem. Biophys. (2005) [Pubmed]
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