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Gene Review

TLR10  -  toll-like receptor 10

Homo sapiens

Synonyms: CD290, Toll-like receptor 10, UNQ315/PRO358
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Disease relevance of TLR10


High impact information on TLR10

  • The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells [1].
  • Analysis of a range of resting and activated human leukocyte populations revealed that mRNA expression of TLR10 was restricted to B cells [1].
  • In addition, keratinocytes ex vivo display TLR1-5, TLR7, and TLR10 [3].
  • Human TLR10 is an orphan member of the TLR family [4].
  • However, a complete TLR10 sequence could be detected in the rat genome, indicating that a functional copy may be preserved in this species [4].
  • TLR10 has sense Alu elements in its 3'UTR region, making it susceptible to the regulation of other protein-coding or non-coding RNAs with antisense Alu elements [5].

Biological context of TLR10


Anatomical context of TLR10


Other interactions of TLR10


Analytical, diagnostic and therapeutic context of TLR10


  1. The toll-like receptor repertoire of human B lymphocytes: inducible and selective expression of TLR9 and TLR10 in normal and transformed cells. Bourke, E., Bosisio, D., Golay, J., Polentarutti, N., Mantovani, A. Blood (2003) [Pubmed]
  2. Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk. Sun, J., Wiklund, F., Zheng, S.L., Chang, B., Bälter, K., Li, L., Johansson, J.E., Li, G., Adami, H.O., Liu, W., Tolin, A., Turner, A.R., Meyers, D.A., Isaacs, W.B., Xu, J., Grönberg, H. J. Natl. Cancer Inst. (2005) [Pubmed]
  3. Human Langerhans Cells Express a Specific TLR Profile and Differentially Respond to Viruses and Gram-Positive Bacteria. Flacher, V., Bouschbacher, M., Verron??se, E., Massacrier, C., Sisirak, V., Berthier-Vergnes, O., de Saint-Vis, B., Caux, C., Dezutter-Dambuyant, C., Lebecque, S., Valladeau, J. J. Immunol. (2006) [Pubmed]
  4. Human TLR10 is a functional receptor, expressed by B cells and plasmacytoid dendritic cells, which activates gene transcription through MyD88. Hasan, U., Chaffois, C., Gaillard, C., Saulnier, V., Merck, E., Tancredi, S., Guiet, C., Brière, F., Vlach, J., Lebecque, S., Trinchieri, G., Bates, E.E. J. Immunol. (2005) [Pubmed]
  5. A gene expression restriction network mediated by sense and antisense Alu sequences located on protein-coding messenger RNAs. Liang, K.H., Yeh, C.T. BMC. Genomics. (2013) [Pubmed]
  6. TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Lazarus, R., Raby, B.A., Lange, C., Silverman, E.K., Kwiatkowski, D.J., Vercelli, D., Klimecki, W.J., Martinez, F.D., Weiss, S.T. Am. J. Respir. Crit. Care Med. (2004) [Pubmed]
  7. Sequence variants in toll-like receptor 10 are associated with nasopharyngeal carcinoma risk. Zhou, X.X., Jia, W.H., Shen, G.P., Qin, H.D., Yu, X.J., Chen, L.Z., Feng, Q.S., Shugart, Y.Y., Zeng, Y.X. Cancer Epidemiol. Biomarkers Prev. (2006) [Pubmed]
  8. Is toll-like receptor 6 or toll-like receptor 10 involved in asthma genetics - or both? Puthothu, B., Heinzmann, A. Allergy (2006) [Pubmed]
  9. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahrsdörfer, B., Giese, T., Endres, S., Hartmann, G. J. Immunol. (2002) [Pubmed]
  10. Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Mansson, A., Adner, M., Cardell, L.O. Respir. Res. (2006) [Pubmed]
  11. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Chuang, T., Ulevitch, R.J. Biochim. Biophys. Acta (2001) [Pubmed]
  12. Toll-like receptors mediate proliferation and survival of multiple myeloma cells. Bohnhorst, J., Rasmussen, T., Moen, S.H., Fløttum, M., Knudsen, L., Børset, M., Espevik, T., Sundan, A. Leukemia (2006) [Pubmed]
  13. Innate immunity in the human female reproductive tract: antiviral response of uterine epithelial cells to the TLR3 agonist poly(I:C). Schaefer, T.M., Fahey, J.V., Wright, J.A., Wira, C.R. J. Immunol. (2005) [Pubmed]
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