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Gene Review

AGL15  -  agamous-like MADS-box protein AGL15

Arabidopsis thaliana

Synonyms: AGAMOUS-like 15, MADS-BOX PROTEIN AGL15, MXE10.8, MXE10_8
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High impact information on AGL15

  • Finally, the MADS box transcription factor AGAMOUS-LIKE15 and an uncharacterized zinc finger protein, a member of the CONSTANS family, were identified as part of the SERK1 complex [1].
  • The expression of DTA1 was positively correlated with AGL15 abundance during embryogenesis [2].
  • One DNA fragment that coprecipitated with AGL15 corresponded to a portion of the regulatory region of a gene named DTA1 (for Downstream Target of AGL15-1) [2].
  • Constitutive expression of AGL15 and of AtGA2ox6 altered endogenous GA amounts and caused GA-deficient phenotypes in Arabidopsis thaliana that could be at least partially rescued by application of biologically active GA [2].
  • The embryo MADS domain protein AGAMOUS-Like 15 directly regulates expression of a gene encoding an enzyme involved in gibberellin metabolism [2].

Biological context of AGL15


Associations of AGL15 with chemical compounds

  • Although ethylene has been implicated in many of these same processes, the effects of AGL15 could be clearly distinguished from the effects of the ethylene resistant1-1 mutation, which confers dominant insensitivity to ethylene [6].

Other interactions of AGL15

  • Cladistic analysis arising from amino acid sequence comparison revealed that STMADS11 shows the highest similarity to STMADS16, another vegetative MADS-box gene from potato, and to the previously reported "orphan" genes AGL15 and AGL17 from Arabidopsis thaliana [7].
  • One of these genes encodes a new member of the MADS domain family of regulatory proteins; it has been designated AGL15 (for AGAMOUS-like) [4].
  • Only for two gene clades, AGL15-like genes (2 genes in Arabidopsis) and FLC-like genes (6 genes) members from plants other than Brassicaceae have not been reported yet [8].
  • AGL15 (AGAMOUS-like 15), a member of the MADS-domain family of regulatory factors, accumulates preferentially in the organs and tissues derived from double fertilization in flowering plants (i.e. the embryo, suspensor, and endosperm) [9].
  • AGL18, which is most similar in sequence to the embryo-expressed AGL15 gene, is expressed in the endosperm and in developing male and female gametophytes, suggesting a role for AGL18 that is distinct from previously characterized MADS-box genes [10].

Analytical, diagnostic and therapeutic context of AGL15


  1. The Arabidopsis SOMATIC EMBRYOGENESIS RECEPTOR-LIKE KINASE1 protein complex includes BRASSINOSTEROID-INSENSITIVE1. Karlova, R., Boeren, S., Russinova, E., Aker, J., Vervoort, J., de Vries, S. Plant Cell (2006) [Pubmed]
  2. The embryo MADS domain protein AGAMOUS-Like 15 directly regulates expression of a gene encoding an enzyme involved in gibberellin metabolism. Wang, H., Caruso, L.V., Downie, A.B., Perry, S.E. Plant Cell (2004) [Pubmed]
  3. Diverse roles for MADS box genes in Arabidopsis development. Rounsley, S.D., Ditta, G.S., Yanofsky, M.F. Plant Cell (1995) [Pubmed]
  4. AGL15, a MADS domain protein expressed in developing embryos. Heck, G.R., Perry, S.E., Nichols, K.W., Fernandez, D.E. Plant Cell (1995) [Pubmed]
  5. Control of expression and autoregulation of AGL15, a member of the MADS-box family. Zhu, C., Perry, S.E. Plant J. (2005) [Pubmed]
  6. The embryo MADS domain factor AGL15 acts postembryonically. Inhibition of perianth senescence and abscission via constitutive expression. Fernandez, D.E., Heck, G.R., Perry, S.E., Patterson, S.E., Bleecker, A.B., Fang, S.C. Plant Cell (2000) [Pubmed]
  7. Isolation and molecular characterization of a new vegetative MADS-box gene from Solanum tuberosum L. Carmona, M.J., Ortega, N., Garcia-Maroto, F. Planta (1998) [Pubmed]
  8. The major clades of MADS-box genes and their role in the development and evolution of flowering plants. Becker, A., Theissen, G. Mol. Phylogenet. Evol. (2003) [Pubmed]
  9. The MADS-domain protein AGAMOUS-like 15 accumulates in embryonic tissues with diverse origins. Perry, S.E., Lehti, M.D., Fernandez, D.E. Plant Physiol. (1999) [Pubmed]
  10. MADS-box gene evolution beyond flowers: expression in pollen, endosperm, guard cells, roots and trichomes. Alvarez-Buylla, E.R., Liljegren, S.J., Pelaz, S., Gold, S.E., Burgeff, C., Ditta, G.S., Vergara-Silva, F., Yanofsky, M.F. Plant J. (2000) [Pubmed]
  11. The MADS domain protein AGL15 localizes to the nucleus during early stages of seed development. Perry, S.E., Nichols, K.W., Fernandez, D.E. Plant Cell (1996) [Pubmed]
  12. Effect of regulated overexpression of the MADS domain factor AGL15 on flower senescence and fruit maturation. Fang, S.C., Fernandez, D.E. Plant Physiol. (2002) [Pubmed]
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