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Gene Review

Slc22a8  -  solute carrier family 22 (organic anion...

Rattus norvegicus

Synonyms: OCT3, Oat3, Organic anion transporter 3, Roct, Solute carrier family 22 member 8, ...
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Disease relevance of Slc22a8

  • In summary, CGNs accumulate MPP+ in manner that is consistent with uptake via OCT3 and the presence of this protein in CGNs explains their sensitivity to MPP+ toxicity [1].

High impact information on Slc22a8

  • In this study, we investigated the involvement of rat organic anion transporter 1 (rOat1; Slc22a6) and rOat3 (Slc22a8) in the uptake of PCG and p-aminohippurate (PAH) by the CP [2].
  • Corticosterone and 17beta-estradiol, known inhibitors of organic cation transporter 3 (OCT3), did not cause any significant inhibition [3].
  • RT-PCR demonstrated that astrocytes expressed low levels of OCT1, OCT2 and OCT3 mRNA, but the functional characteristics of choline uptake are very different from the known properties of these OCTs [3].
  • Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient [4].
  • CGNs in primary culture express OCT3 but do not express mRNA for OCT1, OCT2 or the dopamine transporter [1].

Anatomical context of Slc22a8

  • The role of rat organic anion transporter 3 (rOat3; Slc22a8) in the efflux transport at the blood-brain barrier (BBB) was characterized [5].
  • The purpose of the present study is to examine whether organic anion transporter 3 (Oat3; Slc22a8) is solely responsible for the uptake of 2,4-D by the isolated rat choroid plexus (CP) [6].
  • Cerebellar astrocytes are negative for OCT3 protein by immunocytochemistry [1].
  • OCT3 was moderately expressed in kidney and was highest in blood vessel, skin, and thymus [7].
  • The Oct3-like band was detected only in epithelial cell extracts, the other two bands were also found in fibre cell extracts, whereby the intensity of the Oct2-like band decreased relative to that of the Oct7-like band during differentiation [8].

Associations of Slc22a8 with chemical compounds


Analytical, diagnostic and therapeutic context of Slc22a8


  1. 1-Methyl-4-phenylpyridinium accumulates in cerebellar granule neurons via organic cation transporter 3. Shang, T., Uihlein, A.V., Van Asten, J., Kalyanaraman, B., Hillard, C.J. J. Neurochem. (2003) [Pubmed]
  2. Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the choroid plexus. Nagata, Y., Kusuhara, H., Endou, H., Sugiyama, Y. Mol. Pharmacol. (2002) [Pubmed]
  3. Molecular and functional characterization of an Na+-independent choline transporter in rat astrocytes. Inazu, M., Takeda, H., Matsumiya, T. J. Neurochem. (2005) [Pubmed]
  4. Organic anion transporter 3 (Slc22a8) is a dicarboxylate exchanger indirectly coupled to the Na+ gradient. Sweet, D.H., Chan, L.M., Walden, R., Yang, X.P., Miller, D.S., Pritchard, J.B. Am. J. Physiol. Renal Physiol. (2003) [Pubmed]
  5. Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier. Kikuchi, R., Kusuhara, H., Sugiyama, D., Sugiyama, Y. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  6. Involvement of rat organic anion transporter 3 in the uptake of an organic herbicide, 2,4-dichlorophenoxyacetate, by the isolated rat choroid plexus. Nagata, Y., Kusuhara, H., Imaoka, T., Endou, H., Sugiyama, Y. Journal of pharmaceutical sciences. (2004) [Pubmed]
  7. Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Slitt, A.L., Cherrington, N.J., Hartley, D.P., Leazer, T.M., Klaassen, C.D. Drug Metab. Dispos. (2002) [Pubmed]
  8. Sp1- and octamer-consensus sequence binding proteins during lens fibre differentiation. Brunekreef, G.A., van Genesen, S.T., Lubsen, N.H. Exp. Eye Res. (1997) [Pubmed]
  9. Contribution of organic anion transporters to the renal uptake of anionic compounds and nucleoside derivatives in rat. Hasegawa, M., Kusuhara, H., Endou, H., Sugiyama, Y. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  10. Carrier-mediated uptake of H2-receptor antagonists by the rat choroid plexus: involvement of rat organic anion transporter 3. Nagata, Y., Kusuhara, H., Hirono, S., Endou, H., Sugiyama, Y. Drug Metab. Dispos. (2004) [Pubmed]
  11. Organic cation transporter mRNA and function in the rat superior cervical ganglion. Kristufek, D., Rudorfer, W., Pifl, C., Huck, S. J. Physiol. (Lond.) (2002) [Pubmed]
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