The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

SLC25A18  -  solute carrier family 25 (glutamate...

Homo sapiens

Synonyms: GC-2, GC2, Glutamate/H(+) symporter 2, Mitochondrial glutamate carrier 2, Solute carrier family 25 member 18
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of SLC25A18

  • An oligonucleotide containing this sequence transferred T3 regulation to the herpes simplex virus thymidine kinase promoter in transfected rat pituitary GC2 cells, and specifically bound an in vitro translation product of the human placental c-erb-A gene [1].
  • These data suggest that the GC 2 allele exerts a protective effect, whereas 1F, when homozygous, increases the risk of developing COAD [2].
  • GC2 (lac::luxCDABE) is a constitutive strain, whose bioluminescence is reduced by an increase in cellular toxicity [3].
 

High impact information on SLC25A18

  • The data provide supporting evidence that the human c-erb-A gene product mediates the transcriptional effects of T3 and also that GC2 cell nuclear extracts contain additional factors that modify the binding of pituitary T3 receptors to the rat growth hormone gene T3 response element [1].
  • We report here that the deletion of both GC1 and GC2 rendered rod and cone photoreceptors nonfunctional and unstable [4].
  • Retinal guanylate cyclases 1 and 2 (GC1 and GC2) are responsible for synthesis of cyclic GMP in rods and cones, but their individual contributions to phototransduction are unknown [4].
  • Although only unique rearrangements were amplified from T cells of GC2 and GC3, 11 of 28 potentially functional rearrangements amplified from GC1 originated from four different clones [5].
  • In GC2 patients, a second period of citicoline treatment induced a further (P < 0.01) improvement of VEP and PERG parameters CONCLUSION: Citicoline may induce an improvement of the retinal and of the visual pathway function in patients with glaucoma [6].
 

Biological context of SLC25A18

 

Associations of SLC25A18 with chemical compounds

  • GC3 (3) was found to be the 4-hydroxybenzoate ester derivative of decarbamoylsaxitoxin, while GC1 (1) and GC2 (2) are the epimeric 11-hydroxysulfate derivatives of GC3 (3) [10].
  • In the GC2 phenotype, amino acid 420 is a lysine residue, and in the both common GC1 phenotypes, it is a threonine residue [7].
  • When GC2 grade methylene chloride from Burdick & Jackson Laboratories was used, ETU recoveries ranged from 92 to 110%. "Acceptable" ETU recoveries were defined as those values between 90 and 110% [11].
 

Other interactions of SLC25A18

  • Using the cDNA insert containing the entire coding sequence of GC2, the GC gene was mapped to human chromosomal bands 4q13----q21.1 by in situ hybridization [12].

References

  1. A c-erb-A binding site in rat growth hormone gene mediates trans-activation by thyroid hormone. Glass, C.K., Franco, R., Weinberger, C., Albert, V.R., Evans, R.M., Rosenfeld, M.G. Nature (1987) [Pubmed]
  2. Possible protective effect against chronic obstructive airways disease by the GC2 allele. Horne, S.L., Cockcroft, D.W., Dosman, J.A. Hum. Hered. (1990) [Pubmed]
  3. A multi-channel continuous water toxicity monitoring system: its evaluation and application to water discharged from a power plant. Kim, B.C., Gu, M.B. Environmental monitoring and assessment. (2005) [Pubmed]
  4. The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. Baehr, W., Karan, S., Maeda, T., Luo, D.G., Li, S., Bronson, J.D., Watt, C.B., Yau, K.W., Frederick, J.M., Palczewski, K. J. Biol. Chem. (2007) [Pubmed]
  5. Single-cell PCR analysis of T helper cells in human lymph node germinal centers. Roers, A., Hansmann, M.L., Rajewsky, K., Küppers, R. Am. J. Pathol. (2000) [Pubmed]
  6. Cytidine-5'-diphosphocholine (citicoline) improves retinal and cortical responses in patients with glaucoma. Parisi, V., Manni, G., Colacino, G., Bucci, M.G. Ophthalmology (1999) [Pubmed]
  7. Molecular analysis of the gene for the human vitamin-D-binding protein (group-specific component): allelic differences of the common genetic GC types. Braun, A., Bichlmaier, R., Cleve, H. Hum. Genet. (1992) [Pubmed]
  8. Clonorchis sinensis: Codon usage in nuclear genes. Tang, Y., Cho, P.Y., Kim, T.I., Hong, S.J. Exp. Parasitol. (2007) [Pubmed]
  9. The DNA sequence and structural organization of the GC2 plasmid from the red alga Gracilaria chilensis. Villemur, R. Plant Mol. Biol. (1990) [Pubmed]
  10. Three novel hydroxybenzoate saxitoxin analogues isolated from the dinoflagellate Gymnodinium catenatum. Negri, A., Stirling, D., Quilliam, M., Blackburn, S., Bolch, C., Burton, I., Eaglesham, G., Thomas, K., Walter, J., Willis, R. Chem. Res. Toxicol. (2003) [Pubmed]
  11. Determination of methylene chloride acceptability and its "purification" for ethylenethiourea methodology. Sack, C.A., Kendall, D.C., Krause, R.T. Journal of AOAC International. (1993) [Pubmed]
  12. Chromosomal localization of group-specific component by in situ hybridization. McCombs, J.L., Yang, F., Bowman, B.H., McGill, J.R., Moore, C.M. Cytogenet. Cell Genet. (1986) [Pubmed]
 
WikiGenes - Universities