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Gene Review

C3ar1  -  complement component 3a receptor 1

Rattus norvegicus

Synonyms: C3AR, C3a anaphylatoxin chemotactic receptor, C3a-R
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Disease relevance of C3ar1

  • In experimental allergic encephalitis (EAE), C3aR expression was elevated on microglia, infiltrating monocyte-macrophage cells and a few astrocytes, whereas neuronal expression remained unchanged during the course of the disease [1].

High impact information on C3ar1


Biological context of C3ar1


Anatomical context of C3ar1

  • 5. The C3aRA (1.0 mg x kg(-1)), delivered 120 min prior to reperfusion to remove the global effect of C3aRA-induced neutrophil sequestration, did not attenuate the markers of intestinal I/R, despite persistent C3aR antagonism at this time [6].

Associations of C3ar1 with chemical compounds

  • Rats were treated with either a C5a receptor antagonist (C5aRA, AcF-[OP(d-Cha)WR], 1 mg/kg i.v. or 10 mg/kg p.o.), a C3a receptor antagonist (C3aRA, N(2)-[(2,2-diphenylethoxy)acetyl]-l-arginine, 0.1 mg/kg i.v.) or a convertase inhibitor, rosmarinic acid (RMA, 10 mg/kg i.v.), prior to CVF-induced complement challenge [7].
  • Guinea pigs deficient in C2, C4, C3 or the C3a receptor [8].

Other interactions of C3ar1

  • Here, we show that transient expression of C3aR and C5aR occurs in cerebellar granule neurons in vivo with a maximal density in 12-day-old rat, suggesting a role of these receptors during development of the cerebellum [3].

Analytical, diagnostic and therapeutic context of C3ar1

  • Quantification of the mRNAs by real-time reverse transcription-PCR showed a peak of expression at day 2 in vitro (DIV 2); the C3aR and C5aR proteins were detected by Western blot analysis at DIV 4 and by flow cytometry and immunocytochemistry in differentiating neurons with a maximum density at DIV 4-9 [3].
  • Northern blot analysis of rat C3aR revealed expression in various tissues, similar to that of human C3aR but dissimilar to rat C5aR [9].
  • Moreover, flow cytometry experiments demonstrated the expression of C3aR on normal rat astrocyte membrane [10].


  1. Receptor for the C3a anaphylatoxin is expressed by neurons and glial cells. Davoust, N., Jones, J., Stahel, P.F., Ames, R.S., Barnum, S.R. Glia (1999) [Pubmed]
  2. Characterization of a C3a receptor in rainbow trout and Xenopus: the first identification of C3a receptors in nonmammalian species. Boshra, H., Wang, T., Hove-Madsen, L., Hansen, J., Li, J., Matlapudi, A., Secombes, C.J., Tort, L., Sunyer, J.O. J. Immunol. (2005) [Pubmed]
  3. Characterization of C3a and C5a receptors in rat cerebellar granule neurons during maturation. Neuroprotective effect of C5a against apoptotic cell death. Bénard, M., Gonzalez, B.J., Schouft, M.T., Falluel-Morel, A., Vaudry, D., Chan, P., Vaudry, H., Fontaine, M. J. Biol. Chem. (2004) [Pubmed]
  4. Cutting edge: Differential regulation of chemoattractant receptor-induced degranulation and chemokine production by receptor phosphorylation. Ahamed, J., Haribabu, B., Ali, H. J. Immunol. (2001) [Pubmed]
  5. Contribution of anaphylatoxin C5a to late airway responses after repeated exposure of antigen to allergic rats. Abe, M., Shibata, K., Akatsu, H., Shimizu, N., Sakata, N., Katsuragi, T., Okada, H. J. Immunol. (2001) [Pubmed]
  6. Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. Proctor, L.M., Arumugam, T.V., Shiels, I., Reid, R.C., Fairlie, D.P., Taylor, S.M. Br. J. Pharmacol. (2004) [Pubmed]
  7. Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. Proctor, L.M., Strachan, A.J., Woodruff, T.M., Mahadevan, I.B., Williams, H.M., Shiels, I.A., Taylor, S.M. Int. Immunopharmacol. (2006) [Pubmed]
  8. Guinea pigs deficient in C2, C4, C3 or the C3a receptor. Bitter-Suermann, D., Burger, R. Progress in allergy. (1986) [Pubmed]
  9. Cloning and characterization of rat C3a receptor: differential expression of rat C3a and C5a receptors by LPS stimulation. Fukuoka, Y., Ember, J.A., Hugli, T.E. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  10. Expression of a functional anaphylatoxin C3a receptor by astrocytes. Ischenko, A., Sayah, S., Patte, C., Andreev, S., Gasque, P., Schouft, M.T., Vaudry, H., Fontaine, M. J. Neurochem. (1998) [Pubmed]
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