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Gene Review

FCRLA  -  Fc receptor-like A

Homo sapiens

Synonyms: FCRL, FCRL1, FCRLM1, FCRLX, FCRLa, ...
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Disease relevance of FCRLA


High impact information on FCRLA

  • The observation that FCRL representatives are members of an ancient multigene family that share a common ancestor with the classical FCR is underscored by their linked genomic locations, gene structure, shared extracellular domain composition, and utilization of common cytoplasmic tyrosine-based signaling elements [4].
  • Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis (odds ratio = 2.15, P = 0.00000085) [5].
  • By using specific monoclonal antibodies, we show that FREB is preferentially expressed in germinal center centroblasts, which undergo affinity maturation and class-switch recombination [1].
  • Here, we report the identification of Fc receptor homolog expressed in B cells (FREB), a unique B cell-specific molecule that is distantly related to FcgammaRI (receptor I for the Fc fragment of IgG) and is encoded on human chromosome 1q, within the FcgammaR gene region [1].
  • Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients [2].

Biological context of FCRLA

  • In a database search for additional relatives of this family we identified expressed sequence tag representatives of a new FcR-related molecule (hFcRX) and its mouse ortholog (mFcRX) [6].

Anatomical context of FCRLA

  • Together, these characteristics indicate that FREB may have a unique role in B cell differentiation [1].
  • In COS-7 cells transiently transfected with two human FCRL isoforms, both resided intracellularly [7].
  • Spleen and tonsils were found to be the major sources of FCRL mRNA in human tissues [7].
  • The phylogenetic analysis of the FCRL relationships with the leukocyte FcR supports a view that the three-domain structure was primordial in the evolution of the family [7].
  • FcRX transcripts are found primarily in secondary lymphoid tissues, where they are expressed by B lineage cells [6].

Analytical, diagnostic and therapeutic context of FCRLA


  1. An unusual Fc receptor-related protein expressed in human centroblasts. Facchetti, F., Cella, M., Festa, S., Fremont, D.H., Colonna, M. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  2. Novel melanoma antigen, FCRL/FREB, identified by cDNA profile comparison using DNA chip are immunogenic in multiple melanoma patients. Inozume, T., Matsuzaki, Y., Kurihara, S., Fujita, T., Yamamoto, A., Aburatani, H., Shimada, S., Kawakami, Y. Int. J. Cancer (2005) [Pubmed]
  3. Expression pattern of FCRL (FREB, FcRX) in normal and neoplastic human B cells. Masir, N., Jones, M., Pozzobon, M., Marafioti, T., Volkova, O.Y., Mechetina, L.V., Hansmann, M.L., Natkunam, Y., Taranin, A.V., Mason, D.Y. Br. J. Haematol. (2004) [Pubmed]
  4. Fc receptor-like molecules. Davis, R.S. Annu. Rev. Immunol. (2007) [Pubmed]
  5. A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Kochi, Y., Yamada, R., Suzuki, A., Harley, J.B., Shirasawa, S., Sawada, T., Bae, S.C., Tokuhiro, S., Chang, X., Sekine, A., Takahashi, A., Tsunoda, T., Ohnishi, Y., Kaufman, K.M., Kang, C.P., Kang, C., Otsubo, S., Yumura, W., Mimori, A., Koike, T., Nakamura, Y., Sasazuki, T., Yamamoto, K. Nat. Genet. (2005) [Pubmed]
  6. Definition of an Fc receptor-related gene (FcRX) expressed in human and mouse B cells. Davis, R.S., Li, H., Chen, C.C., Wang, Y.H., Cooper, M.D., Burrows, P.D. Int. Immunol. (2002) [Pubmed]
  7. FCRL, a novel member of the leukocyte Fc receptor family possesses unique structural features. Mechetina, L.V., Najakshin, A.M., Volkova, O.Y., Guselnikov, S.V., Faizulin, R.Z., Alabyev, B.Y., Chikaev, N.A., Vinogradova, M.S., Taranin, A.V. Eur. J. Immunol. (2002) [Pubmed]
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