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Gene Review

SLC43A1  -  solute carrier family 43 (amino acid...

Homo sapiens

Synonyms: L-type amino acid transporter 3, LAT3, Large neutral amino acids transporter small subunit 3, PB39, POV1, ...
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Disease relevance of SLC43A1

  • In situ hybridization of SLC43A1 mRNA showed significantly increased signal intensity in the seminomas [1].
  • The current data support the hypothesis that PB39 plays a role in the development of human prostate cancer and will be useful in the analysis of the gene product in further human and murine studies [2].
  • Comparison of R00504 levels in normal epithelium and invasive carcinoma, using beta-actin as an internal control, showed the transcript to be substantially overexpressed in 5 of 10 carcinomas [3].
  • Identification, analysis, and evolutionary relationships of the putative murine cytomegalovirus homologs of the human cytomegalovirus UL82 (pp71) and UL83 (pp65) matrix phosphoproteins [4].

High impact information on SLC43A1

  • Previously described diagnostic and prognostic markers were found to be expressed by the appropriate GCT subtype (AFP, POU5F1, POV1, CCND2, and KIT) [5].
  • The deduced amino acid sequence of LAT3 was identical to the gene product of POV1 reported as a prostate cancer-up-regulated gene whose function was not determined, whereas it did not exhibit significant similarity to already identified transporters [6].
  • When expressed in Xenopus oocytes, the encoded protein designated LAT3 (L-type amino acid transporter 3) transported neutral amino acids such as l-leucine, l-isoleucine, l-valine, and l-phenylalanine [6].
  • Based on the substrate selectivity, affinity, and N-ethylmaleimide sensitivity, LAT3 is proposed to be a transporter subserving system L2 [6].
  • In contrast, l-leucinol, l-valinol, and l-phenylalaninol, which have a net positive charge induced inward currents under voltage clamp, suggesting these compounds are transported by LAT3 [6].

Biological context of SLC43A1


Anatomical context of SLC43A1

  • Further analysis of PB39 expression in human tissues shows the presence of a unique splice variant mRNA that appears to be primarily associated with fetal tissues and tumors [2].
  • LAT3-mediated transport was inhibited by the pretreatment with N-ethylmaleimide, consistent with the property of system L2 originally characterized in hepatocyte primary culture [6].

Analytical, diagnostic and therapeutic context of SLC43A1


  1. Identification of two molecular groups of seminomas by using expression and tissue microarrays. Hofer, M.D., Browne, T.J., He, L., Skotheim, R.I., Lothe, R.A., Rubin, M.A. Clin. Cancer Res. (2005) [Pubmed]
  2. cDNA sequencing and analysis of POV1 (PB39): a novel gene up-regulated in prostate cancer. Cole, K.A., Chuaqui, R.F., Katz, K., Pack, S., Zhuang, Z., Cole, C.E., Lyne, J.C., Linehan, W.M., Liotta, L.A., Emmert-Buck, M.R. Genomics (1998) [Pubmed]
  3. Identification of a novel transcript up-regulated in a clinically aggressive prostate carcinoma. Chuaqui, R.F., Englert, C.R., Strup, S.E., Vocke, C.D., Zhuang, Z., Duray, P.H., Bostwick, D.G., Linehan, W.M., Liotta, L.A., Emmert-Buck, M.R. Urology (1997) [Pubmed]
  4. Identification, analysis, and evolutionary relationships of the putative murine cytomegalovirus homologs of the human cytomegalovirus UL82 (pp71) and UL83 (pp65) matrix phosphoproteins. Cranmer, L.D., Clark, C.L., Morello, C.S., Farrell, H.E., Rawlinson, W.D., Spector, D.H. J. Virol. (1996) [Pubmed]
  5. Gene expression profiling differentiates germ cell tumors from other cancers and defines subtype-specific signatures. Juric, D., Sale, S., Hromas, R.A., Yu, R., Wang, Y., Duran, G.E., Tibshirani, R., Einhorn, L.H., Sikic, B.I. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  6. Identification of a novel system L amino acid transporter structurally distinct from heterodimeric amino acid transporters. Babu, E., Kanai, Y., Chairoungdua, A., Kim, d.o. .K., Iribe, Y., Tangtrongsup, S., Jutabha, P., Li, Y., Ahmed, N., Sakamoto, S., Anzai, N., Nagamori, S., Endou, H. J. Biol. Chem. (2003) [Pubmed]
  7. EEG1, a putative transporter expressed during epithelial organogenesis: comparison with embryonic transporter expression during nephrogenesis. Stuart, R.O., Pavlova, A., Beier, D., Li, Z., Krijanovski, Y., Nigam, S.K. Am. J. Physiol. Renal Physiol. (2001) [Pubmed]
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