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Gene Review

YRB1  -  Yrb1p

Saccharomyces cerevisiae S288c

Synonyms: CST20, Chromosome stability protein 20, HTN1, Perinuclear array-localized protein, RANBP1, ...
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Disease relevance of YRB1


High impact information on YRB1


Biological context of YRB1


Anatomical context of YRB1

  • Yrb1p is located in the cytosol whereas Nup2p is nuclear [8].
  • Mutation of one of these, YRB1, results in defects in transport of macromolecules across the nuclear envelope (Schlenstedt, G., Wong, D. H., Koepp, D. M., and Silver, P. A. (1995) EMBO J. 14, 5367-5378) [9].
  • In addition to its role in nucleocytoplasmic transport of macromolecules, YRB1/RanBP1 could be involved in the regulation of microtubules structure and dynamics [10].
  • This gene encodes an essential protein that shares homology with the mammalian protein RanBP1 and the protein encoded by the Saccharomyces cerevisiae gene YRB1 and contains a peptide motif present in several proteins found within the nuclear pore complex [11].

Associations of YRB1 with chemical compounds


Physical interactions of YRB1


Regulatory relationships of YRB1

  • While overproduction of Yrb1p inhibited the growth of a mutant possessing a PRP20 mutation (srm1-1) and suppressed the rna1-1 mutation, overproduction of Yrb2p showed no effect on the growth of these mutants [8].

Other interactions of YRB1

  • Yrb1p did not inhibit the Mog1p-stimulated nucleotide release from GTP-Gsp1DeltaC [15].
  • In contrast to Yrb1p, Yrb30p does not coactivate but inhibits RanGAP1(Rna1p)-mediated GTP hydrolysis on Ran, like the karyopherins [16].
  • In contrast to other yrb1 alleles, the new mutation (yrb1-21) does not cause visible defects in import of nuclear proteins Npl3p, histone H2B, or beta-galactosidase fused to a nuclear localization signal [17].
  • The same effect is achieved for the entire Gcn4p in a yrb1 yeast mutant strain impaired in the nuclear import machinery [18].

Analytical, diagnostic and therapeutic context of YRB1


  1. The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating protein. Floer, M., Blobel, G. J. Biol. Chem. (1996) [Pubmed]
  2. Signal transduction through homologs of the Ste20p and Ste7p protein kinases can trigger hyphal formation in the pathogenic fungus Candida albicans. Leberer, E., Harcus, D., Broadbent, I.D., Clark, K.L., Dignard, D., Ziegelbauer, K., Schmidt, A., Gow, N.A., Brown, A.J., Thomas, D.Y. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  3. Mutants in a yeast Ran binding protein are defective in nuclear transport. Schlenstedt, G., Wong, D.H., Koepp, D.M., Silver, P.A. EMBO J. (1995) [Pubmed]
  4. Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development. Köhler, J.R., Fink, G.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway. Künzler, M., Gerstberger, T., Stutz, F., Bischoff, F.R., Hurt, E. Mol. Cell. Biol. (2000) [Pubmed]
  6. Mutations in the YRB1 gene encoding yeast ran-binding-protein-1 that impair nucleocytoplasmic transport and suppress yeast mating defects. Künzler, M., Trueheart, J., Sette, C., Hurt, E., Thorner, J. Genetics (2001) [Pubmed]
  7. Yeast Ran-binding protein Yrb1p is required for efficient proteolysis of cell cycle regulatory proteins Pds1p and Sic1p. Bäumer, M., Künzler, M., Steigemann, P., Braus, G.H., Irniger, S. J. Biol. Chem. (2000) [Pubmed]
  8. Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating protein. Noguchi, E., Hayashi, N., Nakashima, N., Nishimoto, T. Mol. Cell. Biol. (1997) [Pubmed]
  9. Yrb2p is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologue. Taura, T., Schlenstedt, G., Silver, P.A. J. Biol. Chem. (1997) [Pubmed]
  10. Molecular cloning of CaYRB1, the Candida albicans RanBP1/YRB1 homologue. Clément, M., Fournier, H., Ouspenski, I.I., de Repentigny, L., Belhumeur, P. Yeast (2001) [Pubmed]
  11. Characterization of a nuclear protein conferring brefeldin A resistance in Schizosaccharomyces pombe. Turi, T.G., Mueller, U.W., Sazer, S., Rose, J.K. J. Biol. Chem. (1996) [Pubmed]
  12. The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p). Maurer, P., Redd, M., Solsbacher, J., Bischoff, F.R., Greiner, M., Podtelejnikov, A.V., Mann, M., Stade, K., Weis, K., Schlenstedt, G. Mol. Biol. Cell (2001) [Pubmed]
  13. The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases. Hafizi, S., Gustafsson, A., Stenhoff, J., Dahlbäck, B. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  14. Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran GTPase-activating protein (RanGAP) inhibition by karyopherin beta. Lounsbury, K.M., Macara, I.G. J. Biol. Chem. (1997) [Pubmed]
  15. Yrb1p interaction with the gsp1p C terminus blocks Mog1p stimulation of GTP release from Gsp1p. Oki, M., Nishimoto, T. J. Biol. Chem. (2000) [Pubmed]
  16. Identification and characterization of a novel RanGTP-binding protein in the yeast Saccharomyces cerevisiae. Braunwarth, A., Fromont-Racine, M., Legrain, P., Bischoff, F.R., Gerstberger, T., Hurt, E., Kunzler, M. J. Biol. Chem. (2003) [Pubmed]
  17. A RanBP1 mutation which does not visibly affect nuclear import may reveal additional functions of the ran GTPase system. Ouspenski, I.I. Exp. Cell Res. (1998) [Pubmed]
  18. Amino acid-dependent Gcn4p stability regulation occurs exclusively in the yeast nucleus. Pries, R., Bömeke, K., Irniger, S., Grundmann, O., Braus, G.H. Eukaryotic Cell (2002) [Pubmed]
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