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Gene Review

GCM1  -  glial cells missing homolog 1 (Drosophila)

Homo sapiens

Synonyms: Chorion-specific transcription factor GCMa, GCM motif protein 1, GCMA, Glial cells missing homolog 1, hGCMa
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Disease relevance of GCM1

  • GCM1 expression has been shown to affect placental branching and vasculogenesis, abnormalities of which may result in the development of pre-eclampsia [1].
  • Our results suggest that GCM1 is a distinct transcription factor involved in placental disease and altered expression of the GCM1 gene may contribute to the etiology of pre-eclampsia [1].
  • Using G-free reporter constructs carrying multiple copies of wild-type or mutant GCMa-binding site (GBS) in front of a synthetic TATA box, we observed specific transcriptional activities of recombinant hGCMa/1 proteins prepared from a baculovirus--insect cell or Escherichia coli expression system [2].

High impact information on GCM1


Biological context of GCM1


Anatomical context of GCM1


Other interactions of GCM1

  • Median concentrations of PLAC1 and GCM1 mRNA in plasma of pre-eclamptic subjects respectively were 1625 and 2141 copies/ml, significantly higher than 195 and 881 copies/ml, the values for controls (Mann-Whitney test, p<0.001) [9].

Analytical, diagnostic and therapeutic context of GCM1


  1. Decreased placental GCM1 (glial cells missing) gene expression in pre-eclampsia. Chen, C.P., Chen, C.Y., Yang, Y.C., Su, T.H., Chen, H. Placenta (2004) [Pubmed]
  2. Biochemical characterization of the human placental transcription factor GCMa/1. Lin, C., Lin, M., Chen, H. Biochem. Cell Biol. (2005) [Pubmed]
  3. FBW2 targets GCMa to the ubiquitin-proteasome degradation system. Yang, C.S., Yu, C., Chuang, H.C., Chang, C.W., Chang, G.D., Yao, T.P., Chen, H. J. Biol. Chem. (2005) [Pubmed]
  4. A GCM motif protein is involved in placenta-specific expression of human aromatase gene. Yamada, K., Ogawa, H., Honda, S., Harada, N., Okazaki, T. J. Biol. Chem. (1999) [Pubmed]
  5. Expression of GCMB by intrathymic parathyroid hormone-secreting adenomas indicates their parathyroid cell origin. Maret, A., Bourdeau, I., Ding, C., Kadkol, S.S., Westra, W.H., Levine, M.A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  6. Genomic organization, chromosomal localization, and the complete 22 kb DNA sequence of the human GCMa/GCM1, a placenta-specific transcription factor gene. Yamada, K., Ogawa, H., Tamiya, G., Ikeno, M., Morita, M., Asakawa, S., Shimizu, N., Okazaki, T. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  7. Complex patterns of GCM1 mRNA and protein in villous and extravillous trophoblast cells of the human placenta. Baczyk, D., Satkunaratnam, A., Nait-Oumesmar, B., Huppertz, B., Cross, J.C., Kingdom, J.C. Placenta (2004) [Pubmed]
  8. Transforming growth factor-beta induces differentiation of the labyrinthine trophoblast stem cell line SM10. Selesniemi, K., Reedy, M., Gultice, A., Guilbert, L.J., Brown, T.L. Stem Cells Dev. (2005) [Pubmed]
  9. Increased plasma mRnas of placenta-specific 1 (PLAC1) and glial cells-missing 1 (GCM1) in mothers with pre-eclampsia. Fujito, N., Samura, O., Miharu, N., Tanigawa, M., Hyodo, M., Kudo, Y. Hiroshima J. Med. Sci. (2006) [Pubmed]
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