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Gene Review

ADE6  -  phosphoribosylformylglycinamidine synthase

Saccharomyces cerevisiae S288c

Synonyms: FGAM synthase, FGAMS, FGAR amidotransferase, FGAR-AT, Formylglycinamide ribonucleotide amidotransferase, ...
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Disease relevance of ADE6


High impact information on ADE6

  • Diploids homozygous for the mutant gene exhibit elevated frequencies of spontaneous mitotic recombination at the ade6 locus [2].
  • SPT6 was mapped to the right arm of chromosome VII, 44 centimorgans (cM) from ADE6 and 9 cM from CLY8 [3].
  • RME1 was located on chromosome VII, between LEU1 and ADE6 [4].
  • We have shown by tetrad analysis that SUF4 is linked to cly8 and ade6 [5].
  • From the ade6 ade10 amp1 triple mutant, a mutant able to utilize cyclic AMP was isolated, and the mutant phenotype was proven to be due to the simultaneous occurrence of triple mutations designated as cam1, cam2, and cam3 [6].

Biological context of ADE6

  • Mutants able to utilize 5'-AMP or cyclic AMP as the adenine source were isolated from an ade6 ade10 double mutant by ethyl methane sulfonate mutagenesis [6].
  • Cells having the ade6 ade10 amp1 cam1 cam2 cam3 genotype showed significant ability to take up exogenous cyclic AMP, whereas no differences were observed in cyclic AMP phosphodiesterase activity in comparison with that of the original strains used in the mutant isolation [6].
  • Deletion of rhp6 slightly derepressed an ade6 reporter gene placed in the mating-type region, whereas disruption of ubcP3 or ubc15 had no obvious effect on silencing [7].
  • The strain constructed for plasmid shuffling carries auxotrophic markers for ade6, leul, ura4 and his3 along with the can1-1 mutation [8].

Associations of ADE6 with chemical compounds

  • The ADE6 gene of Saccharomyces cerevisiae yeast encoding the enzyme formylglycinamidine-ribonucleotide (FGAM)-synthetase of de novo synthesis of purine nucleotides was cloned and sequenced [9].

Other interactions of ADE6


  1. The ADE2 gene from Saccharomyces cerevisiae: sequence and new vectors. Stotz, A., Linder, P. Gene (1990) [Pubmed]
  2. Recombination in Saccharomyces cerevisiae: a DNA repair mutation associated with elevated mitotic gene conversion. Boram, W.R., Roman, H. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  3. The SPT6 gene is essential for growth and is required for delta-mediated transcription in Saccharomyces cerevisiae. Clark-Adams, C.D., Winston, F. Mol. Cell. Biol. (1987) [Pubmed]
  4. rme1 Mutation of Saccharomyces cerevisiae: map position and bypass of mating type locus control of sporulation. Rine, J., Sprague, G.F., Herskowitz, I. Mol. Cell. Biol. (1981) [Pubmed]
  5. Rearrangement of the genetic map of chromosome VII of Saccharomyces cerevisiae. Celenza, J.L., Carlson, M. Genetics (1985) [Pubmed]
  6. Cyclic AMP may not be involved in catabolite repression in Saccharomyes cerevisiae: evidence from mutants capable of utilizing it as an adenine source. Matsumoto, K., Uno, I., Toh-E, A., Ishikawa, T., Oshima, Y. J. Bacteriol. (1982) [Pubmed]
  7. The fission yeast ubiquitin-conjugating enzymes UbcP3, Ubc15, and Rhp6 affect transcriptional silencing of the mating-type region. Nielsen, I.S., Nielsen, O., Murray, J.M., Thon, G. Eukaryotic Cell (2002) [Pubmed]
  8. Mutational analysis of the gene for Schizosaccharomyces pombe RNase MRP RNA, mrp1, using plasmid shuffle by counterselection on canavanine. Paluh, J.L., Clayton, D.A. Yeast (1996) [Pubmed]
  9. ADE6 gene of Saccharomyces cerevisiae yeast encoding formylglycinamidine-ribonucleotide synthetase. Cloning, sequencing, and analysis. Andreichuk YuV, n.u.l.l., Domkin, V.D., Ryzhova, T.A., Koulikov, V.N., Kostikova, T.R. Biochemistry Mosc. (1997) [Pubmed]
  10. Molecular and genetic characterization of SPT4, a gene important for transcription initiation in Saccharomyces cerevisiae. Malone, E.A., Fassler, J.S., Winston, F. Mol. Gen. Genet. (1993) [Pubmed]
  11. Identification and characterization of four new GCD genes in Saccharomyces cerevisiae. Niederberger, P., Aebi, M., Hütter, R. Curr. Genet. (1986) [Pubmed]
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