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Gene Review

UNG1  -  Ung1p

Saccharomyces cerevisiae S288c

Synonyms: UDG, Uracil-DNA glycosylase, YML021C
 
 
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High impact information on UNG1

  • Analyses with isogenic uracil-DNA-glycosylase (UNG1) deficient or proficient strains indicate that in the absence of dUTPase, cell death results from the incorporation of uracil into DNA and the attempted repair of this damage by UNG1-mediated excision repair [1].
  • Genetic mapping experiments have localized the UNG1 gene on the left arm of chromosome XIII at 17 cM from the GAL80 locus proximal to the centromer [2].
  • The gene product was overproduced about 100-fold in strains carrying an UNG1 gene containing plasmid at 100-200 copies/cell [2].
  • The DNA repair genes RAD54 and UNG1 have MCB elements in their promoters and are shown to be cell cycle regulated [3].
  • Epistasis analyses showed an additive effect between chk1 and ung1, indicating different mechanisms of suppression [4].
 

Biological context of UNG1

 

Anatomical context of UNG1

 

Associations of UNG1 with chemical compounds

 

Other interactions of UNG1

References

  1. dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae. Gadsden, M.H., McIntosh, E.M., Game, J.C., Wilson, P.J., Haynes, R.H. EMBO J. (1993) [Pubmed]
  2. Molecular cloning and primary structure of the uracil-DNA-glycosylase gene from Saccharomyces cerevisiae. Percival, K.J., Klein, M.B., Burgers, P.M. J. Biol. Chem. (1989) [Pubmed]
  3. The DNA repair genes RAD54 and UNG1 are cell cycle regulated in budding yeast but MCB promoter elements have no essential role in the DNA damage response. Johnston, L.H., Johnson, A.L. Nucleic Acids Res. (1995) [Pubmed]
  4. Abrogation of the Chk1-Pds1 checkpoint leads to tolerance of persistent single-strand breaks in Saccharomyces cerevisiae. Karumbati, A.S., Wilson, T.E. Genetics (2005) [Pubmed]
  5. dUTPase activity is critical to maintain genetic stability in Saccharomyces cerevisiae. Guillet, M., Van Der Kemp, P.A., Boiteux, S. Nucleic Acids Res. (2006) [Pubmed]
  6. The spectrum of spontaneous mutations in a Saccharomyces cerevisiae uracil-DNA-glycosylase mutant limits the function of this enzyme to cytosine deamination repair. Impellizzeri, K.J., Anderson, B., Burgers, P.M. J. Bacteriol. (1991) [Pubmed]
  7. Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype. Chatterjee, A., Singh, K.K. Nucleic Acids Res. (2001) [Pubmed]
  8. Selection by genetic transformation of a Saccharomyces cerevisiae mutant defective for the nuclear uracil-DNA-glycosylase. Burgers, P.M., Klein, M.B. J. Bacteriol. (1986) [Pubmed]
  9. Ntg1p, the base excision repair protein, generates mutagenic intermediates in yeast mitochondrial DNA. Phadnis, N., Mehta, R., Meednu, N., Sia, E.A. DNA Repair (Amst.) (2006) [Pubmed]
 
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