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Gene Review

SPE3  -  spermidine synthase

Saccharomyces cerevisiae S288c

Synonyms: Putrescine aminopropyltransferase, SPDSY, Spermidine synthase, YP9499.24C, YPR069C
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Disease relevance of SPE3


High impact information on SPE3


Biological context of SPE3


Associations of SPE3 with chemical compounds


Other interactions of SPE3


  1. Aminopropyltransferases: function, structure and genetics. Ikeguchi, Y., Bewley, M.C., Pegg, A.E. J. Biochem. (2006) [Pubmed]
  2. Studies on the regulation of ornithine decarboxylase in yeast: effect of deletion in the MEU1 gene. Chattopadhyay, M.K., Tabor, C.W., Tabor, H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase. Chattopadhyay, M.K., Tabor, C.W., Tabor, H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Spe3, which encodes spermidine synthase, is required for full repression through NRE(DIT) in Saccharomyces cerevisiae. Friesen, H., Tanny, J.C., Segall, J. Genetics (1998) [Pubmed]
  5. S-adenosylmethionine decarboxylase from baker's yeast. Pösö, H., Sinervirta, R., Jänne, J. Biochem. J. (1975) [Pubmed]
  6. Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. Kingsbury, J.M., Yang, Z., Ganous, T.M., Cox, G.M., McCusker, J.H. Eukaryotic Cell (2004) [Pubmed]
  7. The diverse bacterial origins of the Arabidopsis polyamine biosynthetic pathway. Illingworth, C., Mayer, M.J., Elliott, K., Hanfrey, C., Walton, N.J., Michael, A.J. FEBS Lett. (2003) [Pubmed]
  8. Spermidine biosynthesis in Saccharomyces cerevisae: polyamine requirement of a null mutant of the SPE3 gene (spermidine synthase). Hamasaki-Katagiri, N., Tabor, C.W., Tabor, H. Gene (1997) [Pubmed]
  9. Formation of cadaverine derivatives in Saccharomyces cerevisiae. Walters, D.R., Cowley, T. FEMS Microbiol. Lett. (1996) [Pubmed]
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