The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Srm  -  spermidine synthase

Mus musculus

Synonyms: AA407669, Putrescine aminopropyltransferase, SPDSY, SpdST, SpdSy, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Srm


High impact information on Srm


Biological context of Srm


Anatomical context of Srm


Associations of Srm with chemical compounds


Other interactions of Srm


Analytical, diagnostic and therapeutic context of Srm

  • The transgenic animals expressed the human gene-derived mRNA, as revealed by reverse-transcriptase/PCR analysis, in all tissues studied and displayed tissue spermidine synthase activity that was 2-6 times that in their syngenic littermates [8].
  • Rapid assay of spermidine synthase activity for high-performance liquid chromatography [16].
  • Northern blot analysis showed that the spsA mRNA is expressed maximally during the vegetative stage and decreases gradually during the 24 h of development [10].


  1. Nucleotide sequence of mouse spermidine synthase cDNA. Myöhänen, S., Wahlfors, J., Alhonen, L., Jänne, J. DNA Seq. (1994) [Pubmed]
  2. Polyamines and their biosynthetic enzymes in Ehrlich ascites-carcinoma cells. Modification of tumour polyamine pattern by diamines. Kallio, A., Pösö, H., Guha, S.K., Jänne, J. Biochem. J. (1977) [Pubmed]
  3. Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine synthase against P388 leukemia. Ito, H., Hibasami, H., Shimura, K., Nagai, J., Hidaka, H. Cancer Lett. (1982) [Pubmed]
  4. Antitumor effect of dicyclohexylammonium sulfate, a potent inhibitor of spermidine, synthase. Hibasami, H., Ito, H. Gann = Gan. (1981) [Pubmed]
  5. Gene expression in tobacco low-nicotine mutants. Hibi, N., Higashiguchi, S., Hashimoto, T., Yamada, Y. Plant Cell (1994) [Pubmed]
  6. Effects of difluoromethylornithine and dicyclohexylammonium sulfate on the transformed state of AKR-MCA cells. Boyd, D., Bialoski, S., Brattain, M.G. Cancer Res. (1987) [Pubmed]
  7. Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment. Krauss, M., Langnaese, K., Richter, K., Brunk, I., Wieske, M., Ahnert-Hilger, G., Veh, R.W., Laube, G. J. Neurochem. (2006) [Pubmed]
  8. Transgenic mice over-expressing the human spermidine synthase gene. Kauppinen, L., Myöhänen, S., Halmekytö, M., Alhonen, L., Jänne, J. Biochem. J. (1993) [Pubmed]
  9. Primary structure of rat spermidine synthase: an example of refining the cDNA-derived amino acid sequence. Wada, M., Amano, D., Hosoda, H., Shirahata, A., Samejima, K., Pegg, A.E. Biol. Pharm. Bull. (1999) [Pubmed]
  10. Isolation of spermidine synthase gene (spsA) of Dictyostelium discoideum. Guo, K., Chang, W.T., Newell, P.C. Biochim. Biophys. Acta (1999) [Pubmed]
  11. Hormonal regulation of spermidine synthase during the development of mouse mammary epithelium in vitro. Oka, T., Perry, J.W., Kano, K. Biochem. Biophys. Res. Commun. (1977) [Pubmed]
  12. Regulation of polyamine content in cultured fibroblasts. Bethell, D.R., Hibasami, H., Pegg, A.E. Am. J. Physiol. (1982) [Pubmed]
  13. Specificity of mammalian spermidine synthase and spermine synthase. Pegg, A.E., Shuttleworth, K., Hibasami, H. Biochem. J. (1981) [Pubmed]
  14. Quantitation of S-adenosylmethionine decarboxylase protein. Shirahata, A., Christman, K.L., Pegg, A.E. Biochemistry (1985) [Pubmed]
  15. Stabilization of ornithine decarboxylase in mouse liver and lung by methylglyoxal bis(cyclohexylamidinohydrazone). Hibasami, H., Maekawa, S., Murata, T., Nakashima, K. Biochem. Pharmacol. (1988) [Pubmed]
  16. Rapid assay of spermidine synthase activity for high-performance liquid chromatography. Porta, R., Esposito, C., Sellinger, O.Z. J. Chromatogr. (1981) [Pubmed]
WikiGenes - Universities