The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GADD45GIP1  -  growth arrest and DNA-damage-inducible,...

Homo sapiens

Synonyms: 39S ribosomal protein L59, mitochondrial, CKBBP2, CKII beta-associating protein, CKbetaBP2, CR6-interacting factor 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GADD45GIP1

  • Expression of CRIF1 is barely detectable in adrenal adenoma and papillary thyroid cancer and much lower than in adjacent normal tissue [1].
  • These results suggest that this putative CRIF may be an important component in the development of RA and that regulation of prepro TRH may be highly relevant to the development of other autoimmune diseases that are also exacerbated by low endogenous glucocorticoid levels [2].
  • The overexpression of CRIF1 inhibits the androgen-induced proliferation and cell cycle progression of prostate cancer cells [3].

High impact information on GADD45GIP1


Biological context of GADD45GIP1

  • In this study, we demonstrate that CRIF1 acts as a novel coregulator of transactivation of the orphan nuclear receptor Nur77 [4].
  • As compared with the wild-type CKBBP2/CRIF1 or nonphosphorylatable mutant CKBBP2(S221A) (in which the serine-221 is replaced by alanine), overexpression of CKBBP2(S221E) in COS7 cells promotes cell proliferation [5].

Associations of GADD45GIP1 with chemical compounds


Other interactions of GADD45GIP1

  • In this study, the two-hybrid system was used to define the subregions of CKIIbeta that are involved in the interaction with L5, L41, topoisomerase IIbeta, SAG/CKBBP1, and unknown proteins, CKBBP2 and CKBBP3 [6].

Analytical, diagnostic and therapeutic context of GADD45GIP1


  1. CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle. Chung, H.K., Yi, Y.W., Jung, N.C., Kim, D., Suh, J.M., Kim, H., Park, K.C., Song, J.H., Kim, D.W., Hwang, E.S., Yoon, S.H., Bae, Y.S., Kim, J.M., Bae, I., Shong, M. J. Biol. Chem. (2003) [Pubmed]
  2. A novel endogenous corticotropin release inhibiting factor. Redei, E., Rittenhouse, P.A., Revskoy, S., McGivern, R.F., Aird, F. Ann. N. Y. Acad. Sci. (1998) [Pubmed]
  3. CR6-interacting factor 1 represses the transactivation of androgen receptor by direct interaction. Suh, J.H., Shong, M., Choi, H.S., Lee, K. Mol. Endocrinol. (2008) [Pubmed]
  4. CR6-interacting factor 1 interacts with orphan nuclear receptor Nur77 and inhibits its transactivation. Park, K.C., Song, K.H., Chung, H.K., Kim, H., Kim, D.W., Song, J.H., Hwang, E.S., Jung, H.S., Park, S.H., Bae, I., Lee, I.K., Choi, H.S., Shong, M. Mol. Endocrinol. (2005) [Pubmed]
  5. Phosphorylation of CKBBP2/CRIF1 by protein kinase CKII promotes cell proliferation. Oh, N.S., Yoon, S.H., Lee, W.K., Choi, J.Y., Min, d.o. .S., Bae, Y.S. Gene (2007) [Pubmed]
  6. Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins. Ahn, B.H., Kim, T.H., Bae, Y.S. Mol. Cells (2001) [Pubmed]
WikiGenes - Universities