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Gene Review

PKMYT1  -  protein kinase, membrane associated...

Homo sapiens

Synonyms: MYT1, Membrane-associated tyrosine-and threonine-specific cdc2-inhibitory kinase, Myt1 kinase, PPP1R126
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Disease relevance of PKMYT1

  • Inhibition of PKMYT1 expression by the use of specific short interfering RNAs significantly lowered the TPA-induced KSHV lytic cycle of infection [1].
  • In this study we defined the function of Myt1 by overexpression studies in both S. pombe and a human osteosarcoma cell line [2].

High impact information on PKMYT1


Biological context of PKMYT1

  • In this study, we have examined the substrate specificity and cell cycle regulation of the human Myt1 kinase [6].
  • These findings suggest that human Myt1 is negatively regulated by an M phase-activated kinase and that Myt1 inhibits mitosis due to its specificity for Cdc2.cyclin complexes [6].
  • Phosphorylation of these sites is controlled by the opposing activities of the Wee1/Myt1 kinases and the Cdc25 phosphatase [7].
  • The decreased level of the Tyr15-phosphorylated form of Cdk1 in virus-infected fibroblasts is due in part to the down-regulation of the expression and activity of the Cdk1 inhibitory kinases Myt1 and Wee1 [8].

Anatomical context of PKMYT1


Associations of PKMYT1 with chemical compounds

  • The observed suppression of AhR transcriptional activity by colchicine and nocodazole can be associated with G2/M cell cycle arrest in HepG2 cells, as demonstrated by Myt1 protein hyperphosphorylation and FACS analysis [11].

Enzymatic interactions of PKMYT1


Other interactions of PKMYT1


Analytical, diagnostic and therapeutic context of PKMYT1


  1. Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency. Bryan, B.A., Dyson, O.F., Akula, S.M. J. Gen. Virol. (2006) [Pubmed]
  2. The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. Wells, N.J., Watanabe, N., Tokusumi, T., Jiang, W., Verdecia, M.A., Hunter, T. J. Cell. Sci. (1999) [Pubmed]
  3. Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. Okumura, E., Fukuhara, T., Yoshida, H., Hanada Si, S., Kozutsumi, R., Mori, M., Tachibana, K., Kishimoto, T. Nat. Cell Biol. (2002) [Pubmed]
  4. The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Passer, B.J., Nancy-Portebois, V., Amzallag, N., Prieur, S., Cans, C., Roborel de Climens, A., Fiucci, G., Bouvard, V., Tuynder, M., Susini, L., Morchoisne, S., Crible, V., Lespagnol, A., Dausset, J., Oren, M., Amson, R., Telerman, A. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  5. Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. Liu, F., Rothblum-Oviatt, C., Ryan, C.E., Piwnica-Worms, H. Mol. Cell. Biol. (1999) [Pubmed]
  6. Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. Booher, R.N., Holman, P.S., Fattaey, A. J. Biol. Chem. (1997) [Pubmed]
  7. A human homologue of the checkpoint kinase Cds1 directly inhibits Cdc25 phosphatase. Blasina, A., de Weyer, I.V., Laus, M.C., Luyten, W.H., Parker, A.E., McGowan, C.H. Curr. Biol. (1999) [Pubmed]
  8. Mechanisms governing maintenance of Cdk1/cyclin B1 kinase activity in cells infected with human cytomegalovirus. Sanchez, V., McElroy, A.K., Spector, D.H. J. Virol. (2003) [Pubmed]
  9. The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. Liu, F., Stanton, J.J., Wu, Z., Piwnica-Worms, H. Mol. Cell. Biol. (1997) [Pubmed]
  10. Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation. Dai, X., Yamasaki, K., Yang, L., Sayama, K., Shirakata, Y., Tokumara, S., Yahata, Y., Tohyama, M., Hashimoto, K. J. Invest. Dermatol. (2004) [Pubmed]
  11. Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Dvorák, Z., Vrzal, R., Ulrichová, J., Pascussi, J.M., Maurel, P., Modriansky, M. Curr. Drug Metab. (2006) [Pubmed]
  12. Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. Nakajima, H., Toyoshima-Morimoto, F., Taniguchi, E., Nishida, E. J. Biol. Chem. (2003) [Pubmed]
  13. Cell cycle block and apoptosis induction in a human melanoma cell line following treatment with 2-methoxyoestradiol: therapeutic implications? Ghosh, R., Ott, A.M., Seetharam, D., Slaga, T.J., Kumar, A.P. Melanoma Res. (2003) [Pubmed]
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