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Gene Review

pyrG  -  CTP synthetase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2774, JW2751
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Disease relevance of pyrG


High impact information on pyrG


Chemical compound and disease context of pyrG


Biological context of pyrG

  • The CTP synthetase structure supports a model for gene fusion of a trpG-related glutamine amide transfer domain to a primitive NH3-dependent CTP synthetase [5].
  • The efficiency of co-transformation in Penicillium chrysogenum Wisconsin 54-1255 pyrG(-) and the fate of the transforming DNA were studied using an integrative (pEF43) and an autonomous replicating plasmid (pAM9L) [8].
  • Sequencing of the gene encoding CTP synthetase from this resistant strain revealed a single point mutation, resulting in a change of amino acid 149 from Asp to Glu [4].
  • The results presented here illustrate the sensitivity of sedimentation equilibrium for measuring the aggregation state of equilibrating enzyme species and demonstrate that active site modifications disrupt the quaternary structure of CTP synthetase [9].

Associations of pyrG with chemical compounds


  1. The nucleotide sequence and characterization of the relA gene of Escherichia coli. Metzger, S., Dror, I.B., Aizenman, E., Schreiber, G., Toone, M., Friesen, J.D., Cashel, M., Glaser, G. J. Biol. Chem. (1988) [Pubmed]
  2. Cloning and expression of the Chlamydia trachomatis gene for CTP synthetase. Tipples, G., McClarty, G. J. Biol. Chem. (1995) [Pubmed]
  3. Expression, purification and preliminary X-ray characterization of CTP synthetase from Thermus thermophilus HB8. Goto, M., Omi, R., Hoseki, J., Nakagawa, N., Miyahara, I., Hirotsu, K. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]
  4. A single point mutation in CTP synthetase of Chlamydia trachomatis confers resistance to cyclopentenyl cytosine. Wylie, J.L., Wang, L.L., Tipples, G., McClarty, G. J. Biol. Chem. (1996) [Pubmed]
  5. Nucleotide sequence of Escherichia coli pyrG encoding CTP synthetase. Weng, M., Makaroff, C.A., Zalkin, H. J. Biol. Chem. (1986) [Pubmed]
  6. Plasmids for expression of heterologous proteins in Rhizopus oryzae. Mertens, J.A., Skory, C.D., Ibrahim, A.S. Arch. Microbiol. (2006) [Pubmed]
  7. Structural role for a conserved region in the CTP synthetase glutamine amide transfer domain. Weng, M.L., Zalkin, H. J. Bacteriol. (1987) [Pubmed]
  8. Co-transformation with autonomous replicating and integrative plasmids in Penicillium chrysogenum is highly efficient and leads in some cases to rescue of the intact integrative plasmid. Bañuelos, O., Naranjo, L., Casqueiro, J., Gutiérrez, S., Martín, J.F. Fungal Genet. Biol. (2003) [Pubmed]
  9. Determination of subunit dissociation constants in native and inactivated CTP synthetase by sedimentation equilibrium. Robertson, J.G. Biochemistry (1995) [Pubmed]
  10. High efficiency transformation of Penicillium nalgiovense with integrative and autonomously replicating plasmids. Fierro, F., Laich, F., García-Rico, R.O., Martín, J.F. Int. J. Food Microbiol. (2004) [Pubmed]
  11. Characterization of metal ion activation and inhibition of CTP synthetase. Robertson, J.G., Villafranca, J.J. Biochemistry (1993) [Pubmed]
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