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Gene Review

hisG  -  ATP phosphoribosyltransferase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2014, JW2001
 
 
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Disease relevance of hisG

 

High impact information on hisG

 

Biological context of hisG

  • A comparative analysis of the different transcriptional and translational control elements within the two operons reveals a remarkable preservation for most of them except for the intercistronic region between the first (hisG) and second (hisD) structural genes and for the rho-independent terminator of transcription at the end of the operon [10].
  • The physically linked hisG and hisE genes, encoding for ATP-phosphoribosyltransferase and phosphoribosyl-ATP-pyrophosphohydrolase were isolated from the Corynebacterium glutamicum gene library by complementation of Escherichia coli histidine auxotrophs [11].
 

Associations of hisG with chemical compounds

  • Purine-sensitive His+ revertants of strains able to grow on purines carried second-site mutations which in one case could be shown to map in hisG [12].
 

Other interactions of hisG

 

Analytical, diagnostic and therapeutic context of hisG

References

  1. Cloning of mycobacterial histidine synthesis genes by complementation of a Mycobacterium smegmatis auxotroph. Hinshelwood, S., Stoker, N.G. Mol. Microbiol. (1992) [Pubmed]
  2. Effects of bicyclomycin on RNA- and ATP-binding activities of transcription termination factor Rho. Carrano, L., Bucci, C., De Pascalis, R., Lavitola, A., Manna, F., Corti, E., Bruni, C.B., Alifano, P. Antimicrob. Agents Chemother. (1998) [Pubmed]
  3. Possible hyperattenuation of transcription in the Escherichia coli hisG gene cloned in Bacillus subtilis. Ferretti, L., Mottes, M., Sgaramella, V. Folia Biol. (Praha) (1984) [Pubmed]
  4. Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis. Cho, Y., Sharma, V., Sacchettini, J.C. J. Biol. Chem. (2003) [Pubmed]
  5. Construction of a correlated physical and genetic map of the Klebsiella pneumoniae hisDGO region using transposon Tn5 mutagenesis. de Bruijn, F.J., Stroke, I.L., Marvel, D.J., Ausubel, F.M. EMBO J. (1983) [Pubmed]
  6. DksA potentiates direct activation of amino acid promoters by ppGpp. Paul, B.J., Berkmen, M.B., Gourse, R.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. An aminoacyl-tRNA synthetase paralog with a catalytic role in histidine biosynthesis. Sissler, M., Delorme, C., Bond, J., Ehrlich, S.D., Renault, P., Francklyn, C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  8. The study of guanosine 5'-diphosphate 3'-diphosphate-mediated transcription regulation in vitro using a coupled transcription-translation system. Choy, H.E. J. Biol. Chem. (2000) [Pubmed]
  9. The structure of Escherichia coli ATP-phosphoribosyltransferase: identification of substrate binding sites and mode of AMP inhibition. Lohkamp, B., McDermott, G., Campbell, S.A., Coggins, J.R., Lapthorn, A.J. J. Mol. Biol. (2004) [Pubmed]
  10. Structure and function of the Salmonella typhimurium and Escherichia coli K-12 histidine operons. Carlomagno, M.S., Chiariotti, L., Alifano, P., Nappo, A.G., Bruni, C.B. J. Mol. Biol. (1988) [Pubmed]
  11. Cloning of the histidine biosynthetic genes from Corynebacterium glutamicum: organization and analysis of the hisG and hisE genes. Kwon, J.H., Chun, J.Y., Lee, H.S., Cheon, C.I., Song, E.S., Min, K.H., Lee, M.S. Can. J. Microbiol. (2000) [Pubmed]
  12. Evidence for frameshift mutations in the hisH gene of Escherichia coli causing synthesis of a partially active glutamine amidotransferase. Pons, F.W., Neubert, U., Müller, P. Genetics (1988) [Pubmed]
  13. The leader mRNA of the histidine attenuator region resembles tRNAHis: possible general regulatory implications. Ames, B.N., Tsang, T.H., Buck, M., Christman, M.F. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  14. Inorganic polyphosphate kinase is required to stimulate protein degradation and for adaptation to amino acid starvation in Escherichia coli. Kuroda, A., Tanaka, S., Ikeda, T., Kato, J., Takiguchi, N., Ohtake, H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  15. Purification, crystallization and preliminary X-ray crystallographic analysis of ATP-phosphoribosyltransferase from Escherichia coli. Lohkamp, B., Coggins, J.R., Lapthorn, A.J. Acta Crystallogr. D Biol. Crystallogr. (2000) [Pubmed]
 
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