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Gene Review

hisS  -  histidyl tRNA synthetase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2510, JW2498
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Disease relevance of hisS


High impact information on hisS


Chemical compound and disease context of hisS


Biological context of hisS


Other interactions of hisS


Analytical, diagnostic and therapeutic context of hisS


  1. Primary structure of histidine-tRNA synthetase and characterization of hisS transcripts. Freedman, R., Gibson, B., Donovan, D., Biemann, K., Eisenbeis, S., Parker, J., Schimmel, P. J. Biol. Chem. (1985) [Pubmed]
  2. Cooperative structural dynamics and a novel fidelity mechanism in histidyl-tRNA synthetases. Qiu, X., Janson, C.A., Blackburn, M.N., Chhohan, I.K., Hibbs, M., Abdel-Meguid, S.S. Biochemistry (1999) [Pubmed]
  3. Polymyositis and molecular mimicry, a mechanism of autoimmunity. Walker, E.J., Jeffrey, P.D. Lancet (1986) [Pubmed]
  4. An aminoacyl-tRNA synthetase paralog with a catalytic role in histidine biosynthesis. Sissler, M., Delorme, C., Bond, J., Ehrlich, S.D., Renault, P., Francklyn, C. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. The first step of aminoacylation at the atomic level in histidyl-tRNA synthetase. Arnez, J.G., Augustine, J.G., Moras, D., Francklyn, C.S. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. Crystallization of histidyl-tRNA synthetase from Escherichia coli. Francklyn, C., Harris, D., Moras, D. J. Mol. Biol. (1994) [Pubmed]
  7. G-1:C73 recognition by an arginine cluster in the active site of Escherichia coli histidyl-tRNA synthetase. Connolly, S.A., Rosen, A.E., Musier-Forsyth, K., Francklyn, C.S. Biochemistry (2004) [Pubmed]
  8. A tRNA identity switch mediated by the binding interaction between a tRNA anticodon and the accessory domain of a class II aminoacyl-tRNA synthetase. Yan, W., Augustine, J., Francklyn, C. Biochemistry (1996) [Pubmed]
  9. Affinity labeling of Escherichia coli histidyl-tRNA synthetase with reactive ATP analogues. Identification of labeled amino acid residues by matrix assisted laser desorption-ionization mass spectrometry. Gillet, S., Hoang, C.B., Schmitter, J.M., Fukui, T., Blanquet, S., Hountondji, C. Eur. J. Biochem. (1996) [Pubmed]
  10. The nucleotide sequence of the promoter region of hisS, the structural gene for histidyl-tRNA synthetase. Eisenbeis, S.J., Parker, J. Gene (1982) [Pubmed]
  11. Mutation that suppresses the protein export defect of the secY mutation and causes cold-sensitive growth of Escherichia coli. Shiba, K., Ito, K., Yura, T. J. Bacteriol. (1984) [Pubmed]
  12. Evolutionary conservation of a functionally important backbone phosphate group critical for aminoacylation of histidine tRNAs. Rosen, A.E., Brooks, B.S., Guth, E., Francklyn, C.S., Musier-Forsyth, K. RNA (2006) [Pubmed]
  13. Sequence and characterization of the gcpE gene of Escherichia coli. Baker, J., Franklin, D.B., Parker, J. FEMS Microbiol. Lett. (1992) [Pubmed]
  14. The leader mRNA of the histidine attenuator region resembles tRNAHis: possible general regulatory implications. Ames, B.N., Tsang, T.H., Buck, M., Christman, M.F. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  15. The pAX plasmids: new gene-fusion vectors for sequencing, mutagenesis and expression of proteins in Escherichia coli. Markmeyer, P., Rühlmann, A., Englisch, U., Cramer, F. Gene (1990) [Pubmed]
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