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Gene Review

ubiC  -  chorismate--pyruvate lyase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4031, JW5713
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Disease relevance of ubiC


High impact information on ubiC


Chemical compound and disease context of ubiC


Biological context of ubiC


Associations of ubiC with chemical compounds

  • Although ubiquinone is implicated in antioxidant roles, ubiC expression was not elevated in response to hydrogen peroxide or the redox cycling agent, paraquat [10].
  • Anaerobically utilised electron acceptors (nitrite, nitrate, fumarate) did not affect expression. ubiC expression appears to be negatively regulated by Fnr and IHF [10].
  • Sequencing of the ubiC gene of the mutant strain AN244 revealed a G-->A transition resulting in a change from glutamic acid to lysine [9].
  • 4HB produced by the CPL reaction was utilized for shikonin biosynthesis, as shown by in vivo inhibition of the native pathway to 4HB with 2-aminoindan-2-phosphonic acid (AIP), an inhibitor of phenylalanine ammonia-lyase [7].


  1. Cloning and sequencing of Escherichia coli ubiC and purification of chorismate lyase. Nichols, B.P., Green, J.M. J. Bacteriol. (1992) [Pubmed]
  2. Microbial production of specifically ring-13C-labelled 4-hydroxybenzoic acid. Müller, R., Wagener, A., Schmidt, K., Leistner, E. Appl. Microbiol. Biotechnol. (1995) [Pubmed]
  3. p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis. Stadthagen, G., Korduláková, J., Griffin, R., Constant, P., Bottová, I., Barilone, N., Gicquel, B., Daffé, M., Jackson, M. J. Biol. Chem. (2005) [Pubmed]
  4. Metabolic engineering of the chloroplast genome using the Echerichia coli ubiC gene reveals that chorismate is a readily abundant plant precursor for p-hydroxybenzoic acid biosynthesis. Viitanen, P.V., Devine, A.L., Khan, M.S., Deuel, D.L., Van Dyk, D.E., Daniell, H. Plant Physiol. (2004) [Pubmed]
  5. Genetic engineering of plant secondary metabolism. Accumulation of 4-hydroxybenzoate glucosides as a result of the expression of the bacterial ubiC gene in tobacco. Siebert, M., Sommer, S., Li, S.M., Wang, Z.X., Severin, K., Heide, L. Plant Physiol. (1996) [Pubmed]
  6. Isolation and characterization of suppressors of two Escherichia coli dnaG mutations, dnaG2903 and parB. Britton, R.A., Lupski, J.R. Genetics (1997) [Pubmed]
  7. Genetic engineering of shikonin biosynthesis hairy root cultures of Lithospermum erythrorhizon transformed with the bacterial ubiC gene. Sommer, S., Köhle, A., Yazaki, K., Shimomura, K., Bechthold, A., Heide, L. Plant Mol. Biol. (1999) [Pubmed]
  8. Ubiquinone biosynthesis. Cloning of the genes coding for chorismate pyruvate-lyase and 4-hydroxybenzoate octaprenyl transferase from Escherichia coli. Siebert, M., Bechthold, A., Melzer, M., May, U., Berger, U., Schröder, G., Schröder, J., Severin, K., Heide, L. FEBS Lett. (1992) [Pubmed]
  9. Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase. Siebert, M., Severin, K., Heide, L. Microbiology (Reading, Engl.) (1994) [Pubmed]
  10. Aerobic and anaerobic regulation of the ubiCA operon, encoding enzymes for the first two committed steps of ubiquinone biosynthesis in Escherichia coli. Søballe, B., Poole, R.K. FEBS Lett. (1997) [Pubmed]
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