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Gene Review

ENTPD1  -  ectonucleoside triphosphate...

Homo sapiens

Synonyms: ATPDase, CD39, Ecto-ATP diphosphohydrolase 1, Ecto-ATPDase 1, Ecto-ATPase 1, ...
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Disease relevance of ENTPD1


High impact information on ENTPD1

  • Nucleotides are rapidly converted to adenosine by a family of ecto-nucleotidases including CD39 and CD73 [4].
  • An additional thromboregulatory factor, ATP diphosphohydrolase (ATPDase; designated as EC is also expressed by quiescent EC, and has the capacity to degrade the extracellular inflammatory mediators ATP and ADP to AMP, thereby inhibiting platelet activation and modulating vascular thrombosis [5].
  • Because platelet activation and aggregation are important components of the hemostatic changes that accompany inflammatory diseases, we suggest that the loss of vascular ATPDase may be crucial for the progression of vascular injury [5].
  • We describe here that the antithrombotic effects of the ATPDase, like heparan sulfate and thrombomodulin, are lost after EC activation, both in vitro and in vivo [5].
  • CD39, the major vascular nucleoside triphosphate diphosphohydrolase (NTPDase), converts ATP and ADP to AMP, which is further degraded to the antithrombotic and anti-inflammatory mediator adenosine [6].

Chemical compound and disease context of ENTPD1

  • This suggests that NTPDase (nucleoside triphosphate diphosphohydrolase) could exert a cardioprotective action by reducing ATP-mediated norepinephrine release, thereby offering a novel therapeutic approach to myocardial ischemia and its consequences [7].
  • Total RNA was isolated from cultured glioma C6 cells and the cDNA was analyzed by Real Time-PCR with primers for the NTPDase family [8].

Biological context of ENTPD1


Anatomical context of ENTPD1


Associations of ENTPD1 with chemical compounds


Regulatory relationships of ENTPD1


Other interactions of ENTPD1


Analytical, diagnostic and therapeutic context of ENTPD1


  1. Ecto-ATP diphosphohydrolase/CD39 is overexpressed in differentiated human melanomas. Dzhandzhugazyan, K.N., Kirkin, A.F., thor Straten, P., Zeuthen, J. FEBS Lett. (1998) [Pubmed]
  2. Ectonucleotidases of CD39 family modulate vascular inflammation and thrombosis in transplantation. Robson, S.C., Wu, Y., Sun, X., Knosalla, C., Dwyer, K., Enjyoji, K. Semin. Thromb. Hemost. (2005) [Pubmed]
  3. Upregulation of CD39/NTPDases and P2 receptors in human pancreatic disease. K??nzli, B.M., Berberat, P.O., Giese, T., Csizmadia, E., Kaczmarek, E., Baker, C., Halaceli, I., B??chler, M.W., Friess, H., Robson, S.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2007) [Pubmed]
  4. Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection. Linden, J. Annu. Rev. Pharmacol. Toxicol. (2001) [Pubmed]
  5. Loss of ATP diphosphohydrolase activity with endothelial cell activation. Robson, S.C., Kaczmarek, E., Siegel, J.B., Candinas, D., Koziak, K., Millan, M., Hancock, W.W., Bach, F.H. J. Exp. Med. (1997) [Pubmed]
  6. Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. Dwyer, K.M., Robson, S.C., Nandurkar, H.H., Campbell, D.J., Gock, H., Murray-Segal, L.J., Fisicaro, N., Mysore, T.B., Kaczmarek, E., Cowan, P.J., d'Apice, A.J. J. Clin. Invest. (2004) [Pubmed]
  7. Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases. Marcus, A.J., Broekman, M.J., Drosopoulos, J.H., Islam, N., Pinsky, D.J., Sesti, C., Levi, R. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  8. In vivo glioblastoma growth is reduced by apyrase activity in a rat glioma model. Morrone, F.B., Oliveira, D.L., Gamermann, P., Stella, J., Wofchuk, S., Wink, M.R., Meurer, L., Edelweiss, M.I., Lenz, G., Battastini, A.M. BMC Cancer (2006) [Pubmed]
  9. Cloning and mapping of a human and mouse gene with homology to ecto-ATPase genes. Chadwick, B.P., Frischauf, A.M. Mamm. Genome (1997) [Pubmed]
  10. Cloning, sequencing, and expression of a human brain ecto-apyrase related to both the ecto-ATPases and CD39 ecto-apyrases1. Smith, T.M., Kirley, T.L. Biochim. Biophys. Acta (1998) [Pubmed]
  11. Differential catalytic properties and vascular topography of murine nucleoside triphosphate diphosphohydrolase 1 (NTPDase1) and NTPDase2 have implications for thromboregulation. Sévigny, J., Sundberg, C., Braun, N., Guckelberger, O., Csizmadia, E., Qawi, I., Imai, M., Zimmermann, H., Robson, S.C. Blood (2002) [Pubmed]
  12. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. Synnestvedt, K., Furuta, G.T., Comerford, K.M., Louis, N., Karhausen, J., Eltzschig, H.K., Hansen, K.R., Thompson, L.F., Colgan, S.P. J. Clin. Invest. (2002) [Pubmed]
  13. Cholesterol-dependent lipid assemblies regulate the activity of the ecto-nucleotidase CD39. Papanikolaou, A., Papafotika, A., Murphy, C., Papamarcaki, T., Tsolas, O., Drab, M., Kurzchalia, T.V., Kasper, M., Christoforidis, S. J. Biol. Chem. (2005) [Pubmed]
  14. Nucleoside triphosphate diphosphohydrolase-2 (NTPDase2/CD39L1) is the dominant ectonucleotidase expressed by rat astrocytes. Wink, M.R., Braganhol, E., Tamajusuku, A.S., Lenz, G., Zerbini, L.F., Libermann, T.A., Sévigny, J., Battastini, A.M., Robson, S.C. Neuroscience (2006) [Pubmed]
  15. Stage-specific expression of P2Y receptors, ecto-apyrase, and ecto-5'-nucleotidase in myeloid leukocytes. Clifford, E.E., Martin, K.A., Dalal, P., Thomas, R., Dubyak, G.R. Am. J. Physiol. (1997) [Pubmed]
  16. The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. Maliszewski, C.R., Delespesse, G.J., Schoenborn, M.A., Armitage, R.J., Fanslow, W.C., Nakajima, T., Baker, E., Sutherland, G.R., Poindexter, K., Birks, C. J. Immunol. (1994) [Pubmed]
  17. Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. Eckle, T., Füllbier, L., Wehrmann, M., Khoury, J., Mittelbronn, M., Ibla, J., Rosenberger, P., Eltzschig, H.K. J. Immunol. (2007) [Pubmed]
  18. Suppression of ATP diphosphohydrolase/CD39 in human vascular endothelial cells. Imai, M., Kaczmarek, E., Koziak, K., Sévigny, J., Goepfert, C., Guckelberger, O., Csizmadia, E., Schulte Am Esch, J., Robson, S.C. Biochemistry (1999) [Pubmed]
  19. CD39 modulates endothelial cell activation and apoptosis. Goepfert, C., Imai, M., Brouard, S., Csizmadia, E., Kaczmarek, E., Robson, S.C. Mol. Med. (2000) [Pubmed]
  20. RanBPM associates with CD39 and modulates ecto-nucleotidase activity. Wu, Y., Sun, X., Kaczmarek, E., Dwyer, K.M., Bianchi, E., Usheva, A., Robson, S.C. Biochem. J. (2006) [Pubmed]
  21. Co-localization of P2Y1 receptor and NTPDase1/CD39 within caveolae in human placenta. Kittel, A., Csapó, Z.S., Csizmadia, E., Jackson, S.W., Robson, S.C. European journal of histochemistry : EJH. (2004) [Pubmed]
  22. Reversal of thrombin-induced deactivation of CD39/ATPDase in endothelial cells by HMG-CoA reductase inhibition: effects on Rho-GTPase and adenosine nucleotide metabolism. Kaneider, N.C., Egger, P., Dunzendorfer, S., Noris, P., Balduini, C.L., Gritti, D., Ricevuti, G., Wiedermann, C.J. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  23. Interferon-alpha-induced changes in surface antigens in a hairy-cell leukemia (JOK-1), and a Burkitt's lymphoma cell line (Daudi) during in vitro culture. Nielsen, B., Madsen, P.S., Jensen, A.W., Hokland, P., Hokland, M. Eur. J. Haematol. (1992) [Pubmed]
  24. Characterization of disulfide bonds in human nucleoside triphosphate diphosphohydrolase 3 (NTPDase3): implications for NTPDase structural modeling. Ivanenkov, V.V., Meller, J., Kirley, T.L. Biochemistry (2005) [Pubmed]
  25. Human monocyte derived dendritic cells express functional P2X and P2Y receptors as well as ecto-nucleotidases. Berchtold, S., Ogilvie, A.L., Bogdan, C., Mühl-Zürbes, P., Ogilvie, A., Schuler, G., Steinkasserer, A. FEBS Lett. (1999) [Pubmed]
  26. Ecto-nucleotidases of the CD39/NTPDase family modulate platelet activation and thrombus formation: Potential as therapeutic targets. Atkinson, B., Dwyer, K., Enjyoji, K., Robson, S.C. Blood Cells Mol. Dis. (2006) [Pubmed]
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