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Gene Review

RIN1  -  Ras and Rab interactor 1

Homo sapiens

Synonyms: Ras inhibitor JC99, Ras interaction/interference protein 1
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Disease relevance of RIN1


High impact information on RIN1

  • Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1 [4].
  • RIN1 is tyrosine phosphorylated and is associated with BCR-ABL in human and murine leukemic cells [4].
  • RIN1 exemplifies a new class of effector molecules dependent on the concerted action of the SH3, SH2, and catalytic domains of a cytoplasmic tyrosine kinase [4].
  • These biological effects require tyrosine phosphorylation of RIN1 and binding of RIN1 to the Abl-SH2 and SH3 domains [4].
  • RIN1 interacts with the "effector domain" of RAS and employs some RAS determinants that are common to, and others that are distinct from, those required for the binding of RAF1, a known RAS effector [5].

Biological context of RIN1


Anatomical context of RIN1


Associations of RIN1 with chemical compounds


Regulatory relationships of RIN1

  • Activated RAS participates in a stable RAS-RIN1-ABL2 complex and stimulates the tyrosine kinase-activation function of RIN1 [6].
  • Rin1 is a multifunctional protein that has been shown to regulate EGF receptor signaling and endocytosis [3].
  • RIN1 is also shown to stimulate Rab5 guanine nucleotide exchange, Rab5A-dependent endosome fusion, and EGF receptor-mediated endocytosis [9].
  • Together these results suggest that Rin1 regulates EGFR degradation in cooperation with STAM, defining a novel role for Rin1 in regulating endosomal trafficking [10].

Other interactions of RIN1

  • We demonstrate that the RAS effector protein RIN1 binds to activated RAS with an affinity (K(d), 22 nM) similar to that observed for RAF1 [8].
  • Deletion of the RAS binding domain (RBD) strongly stimulated the ABL2 activation function of RIN1, suggesting that RAS activation results from the relief of RIN1 autoinhibition [6].
  • AF-6 contains two putative Ras-associating domains (RA domains) which are seen in several Ras effectors such as RalGDS and RIN1 [11].
  • Rin1 is a negative regulator of the IL3 receptor signal transduction pathways [3].
  • We conclude that Ras-activated endocytosis is facilitated, in part, by the ability of Ras to directly regulate the Rab5 nucleotide exchange activity of RIN1 [9].

Analytical, diagnostic and therapeutic context of RIN1


  1. A consistent pattern of RIN1 rearrangements in oral squamous cell carcinoma cell lines supports a breakage-fusion-bridge cycle model for 11q13 amplification. Shuster, M.I., Han, L., Le Beau, M.M., Davis, E., Sawicki, M., Lese, C.M., Park, N.H., Colicelli, J., Gollin, S.M. Genes Chromosomes Cancer (2000) [Pubmed]
  2. Analysis of RIN1 gene expression in colorectal cancer. Senda, K., Goi, T., Hirono, Y., Katayama, K., Yamaguchi, A. Oncol. Rep. (2007) [Pubmed]
  3. Rin1 is a negative regulator of the IL3 receptor signal transduction pathways. Hunker, C.M., Galvis, A., Veisaga, M.L., Barbieri, M.A. Anticancer Res. (2006) [Pubmed]
  4. Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1. Afar, D.E., Han, L., McLaughlin, J., Wong, S., Dhaka, A., Parmar, K., Rosenberg, N., Witte, O.N., Colicelli, J. Immunity (1997) [Pubmed]
  5. Protein binding and signaling properties of RIN1 suggest a unique effector function. Han, L., Wong, D., Dhaka, A., Afar, D., White, M., Xie, W., Herschman, H., Witte, O., Colicelli, J. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Hu, H., Bliss, J.M., Wang, Y., Colicelli, J. Curr. Biol. (2005) [Pubmed]
  7. The RAS effector RIN1 modulates the formation of aversive memories. Dhaka, A., Costa, R.M., Hu, H., Irvin, D.K., Patel, A., Kornblum, H.I., Silva, A.J., O'Dell, T.J., Colicelli, J. J. Neurosci. (2003) [Pubmed]
  8. The RAS effector RIN1 directly competes with RAF and is regulated by 14-3-3 proteins. Wang, Y., Waldron, R.T., Dhaka, A., Patel, A., Riley, M.M., Rozengurt, E., Colicelli, J. Mol. Cell. Biol. (2002) [Pubmed]
  9. Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. Tall, G.G., Barbieri, M.A., Stahl, P.D., Horazdovsky, B.F. Dev. Cell (2001) [Pubmed]
  10. Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation. Kong, C., Su, X., Chen, P.I., Stahl, P.D. J. Biol. Chem. (2007) [Pubmed]
  11. In vivo interaction of AF-6 with activated Ras and ZO-1. Yamamoto, T., Harada, N., Kawano, Y., Taya, S., Kaibuchi, K. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  12. The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis. Barbieri, M.A., Kong, C., Chen, P.I., Horazdovsky, B.F., Stahl, P.D. J. Biol. Chem. (2003) [Pubmed]
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