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Gene Review

SLK  -  STE20-like kinase

Homo sapiens

Synonyms: CTCL tumor antigen se20-9, KIAA0204, LOSK, STE20-like serine/threonine-protein kinase, STE20-related kinase, ...
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Disease relevance of SLK


High impact information on SLK

  • Thus, SLK is an anoxia/recovery-dependent kinase that is activated via homodimerization and that signals via ASK1 and p38 to promote apoptosis [1].
  • In contrast, the C-terminal domain of SLK did not dimerize with a related kinase, Mst1, and did not affect Mst1 activity [1].
  • Overexpression of SLK enhanced anoxia/recovery-induced apoptosis, release of cytochrome c, and activities of caspase-8 and -9, and apoptosis was reduced significantly with p38 and caspase-9 inhibitors [1].
  • SLK underwent dimerization via the C-terminal domain, and dimerization enhanced SLK activity [1].
  • Phosphorylation/dephosphorylation of SLK were not associated with changes in kinase activity [1].

Biological context of SLK


Anatomical context of SLK


Other interactions of SLK


Analytical, diagnostic and therapeutic context of SLK


  1. Induction of apoptosis by the Ste20-like kinase SLK, a germinal center kinase that activates apoptosis signal-regulating kinase and p38. Hao, W., Takano, T., Guillemette, J., Papillon, J., Ren, G., Cybulsky, A.V. J. Biol. Chem. (2006) [Pubmed]
  2. Up-Regulation of Bcl-2 in microvascular endothelial cells enhances intratumoral angiogenesis and accelerates tumor growth. Nör, J.E., Christensen, J., Liu, J., Peters, M., Mooney, D.J., Strieter, R.M., Polverini, P.J. Cancer Res. (2001) [Pubmed]
  3. Molecular cloning and characterization of a novel human STE20-like kinase, hSLK. Yamada, E., Tsujikawa, K., Itoh, S., Kameda, Y., Kohama, Y., Yamamoto, H. Biochim. Biophys. Acta (2000) [Pubmed]
  4. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. Zhou, T.H., Ling, K., Guo, J., Zhou, H., Wu, Y.L., Jing, Q., Ma, L., Pei, G. J. Biol. Chem. (2000) [Pubmed]
  5. The 3'-untranslated region of the Ste20-like kinase SLK regulates SLK expression. Cybulsky, A.V., Takano, T., Papillon, J., Hao, W., Mancini, A., Di Battista, J.A., Cybulsky, M.I. Am. J. Physiol. Renal Physiol. (2007) [Pubmed]
  6. Cloning and characterization of MST4, a novel Ste20-like kinase. Qian, Z., Lin, C., Espinosa, R., LeBeau, M., Rosner, M.R. J. Biol. Chem. (2001) [Pubmed]
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