Disease relevance of RP6-213H19.1

• The Ste20 kinase MST4 plays a role in prostate cancer progression [1].
• Oesophageal Vent-Laryngeal Mask to prevent aspiration of gastric contents [2].
• The extent of emphysema was determined by HRCT at both full inspiration, emph.I(%) and at full expiration, emph.E(%), with a cut-off limit of -910 Hounsfield Units (HU) using the "Density Mask" method [3].
• The Laryngeal Mask Airway (LMA) was used during the resuscitation process in two patients with severe tracheal stenosis [4].
• Insertion of Laryngeal Mask Airway for a paediatric orthopaedic case with coincidental cleft palate [5].

High impact information on RP6-213H19.1

• Overexpression of wild-type MST4 induced anchorage-independent growth of the LNCaP cell line, and increased both in vitro proliferation and in vivo tumorigenesis of the DU 145 cell line [1].
• Ectopic expression of wild-type and kinase-inactive MST4 was used to alter cellular MST4 activity levels in three widely studied human prostate tumor cell lines: LNCaP, DU 145, and PC-3 [1].
• Cloning and characterization of MST4, a novel Ste20-like kinase [6].
• MST4, a novel member of the germinal center kinase subfamily of human Ste20-like kinases, was cloned and characterized [6].
• Northern blot analysis indicates that MST4 is ubiquitously distributed, and the MST4 gene is localized to chromosome Xq26, a disease-rich region, by fluorescence in situ hybridization [6].

Biological context of RP6-213H19.1

• Together, our studies suggest a potential role for MST4 in the signal transduction pathways involved in prostate cancer progression [1].
• An alternatively spliced isoform of MST4 (MST4a) was isolated by yeast two-hybrid interaction with the catalytic domain of Raf from a human fetal brain cDNA library and also found in a variety of human fetal and adult tissues [6].
• Using atmospheric pressure to inflate the cuff of the Portex Laryngeal Mask [7].
• INTRODUCTION: Mask ventilation is a procedure routinely used in emergency medicine [8].
• Although both resulted in a decrease of the visual fields, the magnitude of restrictions was far less with the MCU-2/P Chemical-Biological Mask [9].

Anatomical context of RP6-213H19.1

• HeLa and Phoenix cell lines overexpressing wild-type, but not kinase-dead, MST4 exhibit increased growth rate and form aggressive soft-agar colonies [10].
• Northern blot analysis indicated that MST4 is highly expressed in placenta, thymus, and peripheral blood leukocytes [10].
• Overlapping of the right internal jugular vein (IJV) and common carotid artery (CCA) after placement of an LMA-Classic (Laryngeal Mask Company, Henley-on-Thames, United Kingdom) was investigated using an ultrasound scanner [11].
• CONCLUSIONS: Mask CPAP and nasal BiPAP after extubation of the trachea prevent the increase in extravascular lung water during weaning from mechanical ventilation [12].
• Randomized comparison of the SLIPA (Streamlined Liner of the Pharynx Airway) and the SS-LM (Soft Seal Laryngeal Mask) by medical students [13].

Associations of RP6-213H19.1 with chemical compounds

• MST4, a member of the Sterile 20 serine/threonine kinase family, was found to be expressed in prostate carcinoma tumor samples and cell lines [1].
• Noninvasive Ventilation versus Nonrebreather Bag-Valve Mask to Achieve Preoxygenation before Intubation of Hypoxic Patients [14].
• BACKGROUND: Inhalational induction with sevoflurane and nitrous oxide is frequently used for Laryngeal Mask Airway (LMA; Laryngeal Mask Company, Henley-on-Thames, United Kingdom) insertion in children [15].
• A significant Group x Mask Condition interaction was found when a P target was used in combination with an M or P mask, but not when an M target was used [16].
• Our aim was to evaluate the performance of the Cobra Perilaryngeal Airway in a cohort study and in a randomised, controlled, crossover comparison study with the Classic Laryngeal Mask Airway [17].

Enzymatic interactions of RP6-213H19.1

• Wild-type but not kinase-dead MST4 can phosphorylate myelin basic protein in an in vitro kinase assay [10].

Analytical, diagnostic and therapeutic context of RP6-213H19.1

• BACKGROUND: The intubating laryngeal mask airway (ILMA; Fastrach; Laryngeal Mask Company, Henley-on-Thames, UK) may provide an alternative technique to fiberoptic intubation (FIB) to facilitate the management of the anticipated difficult airway [18].
• Laryngeal resistance before and after minor surgery: endotracheal tube versus Laryngeal Mask Airway [19].
• The prediction probability was calculated for discrimination between the predefined case milestones Awake, Spontaneous Eye Closure, and insertion of a laryngeal mask airway during general anesthesia (Laryngeal Mask Insertion) [20].
• The Laryngeal Mask Airway audio monitor. Obtaining breath sounds from the Laryngeal Mask Airway: a new device for patient monitoring [21].
• The Laerdal Pocket Mask is an ineffective device for infant mannequin ventilation and should not be recommended for infant resuscitation [22].

References