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Gene Review

STK24  -  serine/threonine kinase 24

Homo sapiens

Synonyms: HEL-S-95, MST-3, MST3, MST3B, Mammalian STE20-like protein kinase 3, ...
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Disease relevance of STK24


High impact information on STK24


Biological context of STK24

  • Collectively, these results support the notion that caspase-mediated proteolytic activation of Mst3 contributes to apoptosis [4].
  • Ectopic expression of either wild-type or COOH-terminal truncated Mst3 in cells results in DNA fragmentation and morphological changes characteristic of apoptosis [4].
  • A novel isoform of mammalian STE20-like kinase 3 (MST3) with a different 5' coding region from MST3, termed MST3b, was identified by searching through expressed sequence tag data base and obtained by rapid amplification of cDNA 5'-ends [5].
  • Inhibition of Cell Migration by Autophosphorylated Mammalian Sterile 20-Like Kinase 3 (MST3) Involves Paxillin and Protein-tyrosine Phosphatase-PEST [3].
  • Suppression of endogenous MST3 by small interference RNA enhanced cellular migration in MCF-7 cells with reduced expression of E-cadherin at the edge of migrating cells [3].

Anatomical context of STK24

  • Mammalian Sterile 20-like kinase 3 (Mst3), the physiological functions of which are unknown, is a member of the germinal center kinase-III family [4].
  • In this study we demonstrate that endogenous Mst3 is specifically cleaved when Jurkat cells were treated with anti-Fas antibody or staurosporine and that this cleavage is inhibited by the caspase inhibitor, Ac-DEVD-CHO [4].

Associations of STK24 with chemical compounds

  • Further experiments demonstrated that MST3b, but not MST3, was effectively phosphorylated by activation of cyclic AMP-dependent protein kinase (PKA) in both in vivo and in vitro assays [5].
  • MST3 could phosphorylate the protein-tyrosine phosphatase (PTP)-PEST and inhibit the tyrosine phosphatase activity of PTP-PEST [3].
  • Threonine 178 was determined to be one of the two main autophosphorylation sites of MST3 in vitro [3].
  • Mutant T178A MST3, containing alanine instead of threonine at codon 178, lost autophosphorylation and kinase activities [3].
  • MST3 is a member of the sterile-20 protein kinase family with a unique preference for manganese ion as a cofactor in vitro; however, its biological function is largely unknown [3].

Other interactions of STK24

  • Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis [4].

Analytical, diagnostic and therapeutic context of STK24

  • Reverse transcription-polymerase chain reaction and Northern blot analysis with a probe derived from 5' distinct sequence of MST3b revealed that the expression of MST3b mRNA is restricted to the brain, in contrast to ubiquitous distribution of MST3 transcript [5].


  1. Expression profiling of t(12;22) positive clear cell sarcoma of soft tissue cell lines reveals characteristic up-regulation of potential new marker genes including ERBB3. Schaefer, K.L., Brachwitz, K., Wai, D.H., Braun, Y., Diallo, R., Korsching, E., Eisenacher, M., Voss, R., Van Valen, F., Baer, C., Selle, B., Spahn, L., Liao, S.K., Lee, K.A., Hogendoorn, P.C., Reifenberger, G., Gabbert, H.E., Poremba, C. Cancer Res. (2004) [Pubmed]
  2. Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3. Stegert, M.R., Hergovich, A., Tamaskovic, R., Bichsel, S.J., Hemmings, B.A. Mol. Cell. Biol. (2005) [Pubmed]
  3. Inhibition of Cell Migration by Autophosphorylated Mammalian Sterile 20-Like Kinase 3 (MST3) Involves Paxillin and Protein-tyrosine Phosphatase-PEST. Lu, T.J., Lai, W.Y., Huang, C.Y., Hsieh, W.J., Yu, J.S., Hsieh, Y.J., Chang, W.T., Leu, T.H., Chang, W.C., Chuang, W.J., Tang, M.J., Chen, T.Y., Lu, T.L., Lai, M.D. J. Biol. Chem. (2006) [Pubmed]
  4. Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis. Huang, C.Y., Wu, Y.M., Hsu, C.Y., Lee, W.S., Lai, M.D., Lu, T.J., Huang, C.L., Leu, T.H., Shih, H.M., Fang, H.I., Robinson, D.R., Kung, H.J., Yuan, C.J. J. Biol. Chem. (2002) [Pubmed]
  5. Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase. Zhou, T.H., Ling, K., Guo, J., Zhou, H., Wu, Y.L., Jing, Q., Ma, L., Pei, G. J. Biol. Chem. (2000) [Pubmed]
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