Gene Review:
SETDB1 - SET domain, bifurcated 1
Homo sapiens
Synonyms:
ERG-associated protein with SET domain, ESET, H3-K9-HMTase 4, H3-K9-HMTase4, Histone H3-K9 methyltransferase 4, ...
- ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease. Ryu, H., Lee, J., Hagerty, S.W., Soh, B.Y., McAlpin, S.E., Cormier, K.A., Smith, K.M., Ferrante, R.J. Proc. Natl. Acad. Sci. U.S.A. (2006)
- SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Schultz, D.C., Ayyanathan, K., Negorev, D., Maul, G.G., Rauscher, F.J. Genes Dev. (2002)
- Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Sarraf, S.A., Stancheva, I. Mol. Cell (2004)
- mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression. Wang, H., An, W., Cao, R., Xia, L., Erdjument-Bromage, H., Chatton, B., Tempst, P., Roeder, R.G., Zhang, Y. Mol. Cell (2003)
- Assignment of a novel bifurcated SET domain gene, SETDB1, to human chromosome band 1q21 by in situ hybridization and radiation hybrids. Harte, P.J., Wu, W., Carrasquillo, M.M., Matera, A.G. Cytogenet. Cell Genet. (1999)
- In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation. Verschure, P.J., van der Kraan, I., de Leeuw, W., van der Vlag, J., Carpenter, A.E., Belmont, A.S., van Driel, R. Mol. Cell. Biol. (2005)
- The histone methyltransferase SETDB1 and the DNA methyltransferase DNMT3A interact directly and localize to promoters silenced in cancer cells. Li, H., Rauch, T., Chen, Z.X., Szabó, P.E., Riggs, A.D., Pfeifer, G.P. J. Biol. Chem. (2006)
- An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Yang, L., Mei, Q., Zielinska-Kwiatkowska, A., Matsui, Y., Blackburn, M.L., Benedetti, D., Krumm, A.A., Taborsky, G.J., Chansky, H.A. Biochem. J. (2003)
- Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins. Ichimura, T., Watanabe, S., Sakamoto, Y., Aoto, T., Fujita, N., Nakao, M. J. Biol. Chem. (2005)
- Regulation of MBD1-mediated transcriptional repression by SUMO and PIAS proteins. Lyst, M.J., Nan, X., Stancheva, I. EMBO J. (2006)
- Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Yang, L., Xia, L., Wu, D.Y., Wang, H., Chansky, H.A., Schubach, W.H., Hickstein, D.D., Zhang, Y. Oncogene (2002)