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Gene Review

TP53BP2  -  tumor protein p53 binding protein 2

Homo sapiens

Synonyms: 53BP2, ASPP2, Apoptosis-stimulating of p53 protein 2, BBP, Bbp, ...
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Disease relevance of TP53BP2


Psychiatry related information on TP53BP2


High impact information on TP53BP2


Biological context of TP53BP2


Anatomical context of TP53BP2


Associations of TP53BP2 with chemical compounds


Physical interactions of TP53BP2


Regulatory relationships of TP53BP2

  • ASPP2 can specifically stimulate the apoptotic function of p53 but not cell cycle arrest, but the mechanism of enhancing the activation of pro-apoptotic genes over cell cycle arrest genes remains unknown [20].

Other interactions of TP53BP2

  • ASPP1 and ASPP2 are new transcriptional targets of E2F [21].
  • However, coexpression of the core with p53 and ASPP2 increased the number of surviving cells [19].
  • APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus [22].
  • An in vitro binding assay indicated that the Src-homology-3 domain and the ankyrin-repeat domain of 53BP2 were both required for binding to the COOH-terminus of APCL [22].
  • We also show that ASPP2 activates nuclear factor-kappaB (NF-kappaB) transcriptional activity, which seems to be inhibited by the neddylation pathway since the dominant negative NEDD8 activating enzyme causes enhanced NF-kappaB activity [23].

Analytical, diagnostic and therapeutic context of TP53BP2


  1. TP53BP2 locus is associated with gastric cancer susceptibility. Ju, H., Lee, K.A., Yang, M., Kim, H.J., Kang, C.P., Sohn, T.S., Rhee, J.C., Kang, C., Kim, J.W. Int. J. Cancer (2005) [Pubmed]
  2. Aberrant overexpression of 53BP2 mRNA in lung cancer cell lines. Mori, T., Okamoto, H., Takahashi, N., Ueda, R., Okamoto, T. FEBS Lett. (2000) [Pubmed]
  3. Distinct residues of human p53 implicated in binding to DNA, simian virus 40 large T antigen, 53BP1, and 53BP2. Thukral, S.K., Blain, G.C., Chang, K.K., Fields, S. Mol. Cell. Biol. (1994) [Pubmed]
  4. Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness. Zhao, X., Ayer, R.E., Davis, S.L., Ames, S.J., Florence, B., Torchinsky, C., Liou, J.S., Shen, L., Spanjaard, R.A. Cancer Res. (2005) [Pubmed]
  5. beta -Amyloid peptide-induced apoptosis regulated by a novel protein containing a g protein activation module. Kajkowski, E.M., Lo, C.F., Ning, X., Walker, S., Sofia, H.J., Wang, W., Edris, W., Chanda, P., Wagner, E., Vile, S., Ryan, K., McHendry-Rinde, B., Smith, S.C., Wood, A., Rhodes, K.J., Kennedy, J.D., Bard, J., Jacobsen, J.S., Ozenberger, B.A. J. Biol. Chem. (2001) [Pubmed]
  6. Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2. Gorina, S., Pavletich, N.P. Science (1996) [Pubmed]
  7. Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly. Sarraf, S.A., Stancheva, I. Mol. Cell (2004) [Pubmed]
  8. ASPP proteins specifically stimulate the apoptotic function of p53. Samuels-Lev, Y., O'Connor, D.J., Bergamaschi, D., Trigiante, G., Hsieh, J.K., Zhong, S., Campargue, I., Naumovski, L., Crook, T., Lu, X. Mol. Cell (2001) [Pubmed]
  9. The E1B 19K/Bcl-2-binding protein Nip3 is a dimeric mitochondrial protein that activates apoptosis. Chen, G., Ray, R., Dubik, D., Shi, L., Cizeau, J., Bleackley, R.C., Saxena, S., Gietz, R.D., Greenberg, A.H. J. Exp. Med. (1997) [Pubmed]
  10. 53BP2 induces apoptosis through the mitochondrial death pathway. Kobayashi, S., Kajino, S., Takahashi, N., Kanazawa, S., Imai, K., Hibi, Y., Ohara, H., Itoh, M., Okamoto, T. Genes Cells (2005) [Pubmed]
  11. Expression of 53BP2 and ASPP2 proteins from TP53BP2 gene by alternative splicing. Takahashi, N., Kobayashi, S., Jiang, X., Kitagori, K., Imai, K., Hibi, Y., Okamoto, T. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  12. Assignment of p53 binding protein (TP53BP2) to human chromosome band 1q42.1 by in situ hybridization. Yang, J.P., Ono, T., Sonta, S., Kawabe, T., Okamoto, T. Cytogenet. Cell Genet. (1997) [Pubmed]
  13. The p53-binding protein 53BP2 also interacts with Bc12 and impedes cell cycle progression at G2/M. Naumovski, L., Cleary, M.L. Mol. Cell. Biol. (1996) [Pubmed]
  14. Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53. Lopez, C.D., Ao, Y., Rohde, L.H., Perez, T.D., O'Connor, D.J., Lu, X., Ford, J.M., Naumovski, L. Mol. Cell. Biol. (2000) [Pubmed]
  15. p53-interacting protein 53BP2 inhibits clonogenic survival and sensitizes cells to doxorubicin but not paclitaxel-induced apoptosis. Ao, Y., Rohde, L.H., Naumovski, L. Oncogene (2001) [Pubmed]
  16. Apoptosis stimulating protein of p53 (ASPP2) expression differs in diffuse large B-cell and follicular center lymphoma: correlation with clinical outcome. Lossos, I.S., Natkunam, Y., Levy, R., Lopez, C.D. Leuk. Lymphoma (2002) [Pubmed]
  17. Nitric oxide suppresses the expression of Bcl-2 binding protein BNIP3 in hepatocytes. Zamora, R., Alarcon, L., Vodovotz, Y., Betten, B., Kim, P.K., Gibson, K.F., Billiar, T.R. J. Biol. Chem. (2001) [Pubmed]
  18. Estrogen neuroprotection: the involvement of the Bcl-2 binding protein BNIP2. Belcredito, S., Vegeto, E., Brusadelli, A., Ghisletti, S., Mussi, P., Ciana, P., Maggi, A. Brain Res. Brain Res. Rev. (2001) [Pubmed]
  19. Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis. Cao, Y., Hamada, T., Matsui, T., Date, T., Iwabuchi, K. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  20. Effects of Oncogenic Mutations and DNA Response Elements on the Binding of p53 to p53-binding Protein 2 (53BP2). Tidow, H., Veprintsev, D.B., Freund, S.M., Fersht, A.R. J. Biol. Chem. (2006) [Pubmed]
  21. ASPP1 and ASPP2 are new transcriptional targets of E2F. Fogal, V., Kartasheva, N.N., Trigiante, G., Llanos, S., Yap, D., Vousden, K.H., Lu, X. Cell Death Differ. (2005) [Pubmed]
  22. APCL, a central nervous system-specific homologue of adenomatous polyposis coli tumor suppressor, binds to p53-binding protein 2 and translocates it to the perinucleus. Nakagawa, H., Koyama, K., Murata, Y., Morito, M., Akiyama, T., Nakamura, Y. Cancer Res. (2000) [Pubmed]
  23. ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. Chen, Y., Liu, W., Naumovski, L., Neve, R.L. J. Neurochem. (2003) [Pubmed]
  24. Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. Helps, N.R., Barker, H.M., Elledge, S.J., Cohen, P.T. FEBS Lett. (1995) [Pubmed]
  25. p53 apoptotic pathway molecules are frequently and simultaneously altered in nonsmall cell lung carcinoma. Mori, S., Ito, G., Usami, N., Yoshioka, H., Ueda, Y., Kodama, Y., Takahashi, M., Fong, K.M., Shimokata, K., Sekido, Y. Cancer (2004) [Pubmed]
  26. Identification of a novel inhibitor of nuclear factor-kappaB, RelA-associated inhibitor. Yang, J.P., Hori, M., Sanda, T., Okamoto, T. J. Biol. Chem. (1999) [Pubmed]
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