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MeSH Review

Simian Acquired Immunodeficiency Syndrome

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Disease relevance of Simian Acquired Immunodeficiency Syndrome


High impact information on Simian Acquired Immunodeficiency Syndrome


Chemical compound and disease context of Simian Acquired Immunodeficiency Syndrome


Gene context of Simian Acquired Immunodeficiency Syndrome

  • Activation of opioid receptors by morphine was previously shown to specifically induce the expression of chemokine receptor CCR5, promoting simian AIDS virus entry and replication in immune cells [15].
  • The N-terminal region of Nef has been directly implicated in development of simian AIDS [16].
  • The original basis of this hypothesis came from evidence that monkeys infected with a nef-deleted SIV strain failed to develop simian AIDS [17].


  1. Isolation of an HTLV-III-related retrovirus from macaques with simian AIDS and its possible origin in asymptomatic mangabeys. Murphey-Corb, M., Martin, L.N., Rangan, S.R., Baskin, G.B., Gormus, B.J., Wolf, R.H., Andes, W.A., West, M., Montelaro, R.C. Nature (1986) [Pubmed]
  2. Functional interaction and partial homology between human immunodeficiency virus and neuroleukin. Lee, M.R., Ho, D.D., Gurney, M.E. Science (1987) [Pubmed]
  3. Mucosal transmission and induction of simian AIDS by CCR5-specific simian/human immunodeficiency virus SHIV(SF162P3). Harouse, J.M., Gettie, A., Eshetu, T., Tan, R.C., Bohm, R., Blanchard, J., Baskin, G., Cheng-Mayer, C. J. Virol. (2001) [Pubmed]
  4. Seroepidemiologic survey of captive Old-World primates for antibodies to human and simian retroviruses, and isolation of a lentivirus from sooty mangabeys (Cercocebus atys). Lowenstine, L.J., Pedersen, N.C., Higgins, J., Pallis, K.C., Uyeda, A., Marx, P., Lerche, N.W., Munn, R.J., Gardner, M.B. Int. J. Cancer (1986) [Pubmed]
  5. Monoclonal antibodies to type D retrovirus (SRV-2). Tsai, C.C., Tsai, C.C., Sligh, J.M., Yarnall, M., Follis, K.E., Roodman, S.T. J. Med. Primatol. (1989) [Pubmed]
  6. Increased ratio of quinolinic acid to kynurenic acid in cerebrospinal fluid of D retrovirus-infected rhesus macaques: relationship to clinical and viral status. Heyes, M.P., Mefford, I.N., Quearry, B.J., Dedhia, M., Lackner, A. Ann. Neurol. (1990) [Pubmed]
  7. Cerebrospinal fluid and serum neopterin and biopterin in D-retrovirus-infected rhesus macaques (Macaca mulatta): relationship to clinical and viral status. Heyes, M.P., Lackner, A., Kaufman, S., Milstien, S. AIDS (1991) [Pubmed]
  8. Induction of simian AIDS in infant rhesus macaques infected with CCR5- or CXCR4-utilizing simian-human immunodeficiency viruses is associated with distinct lesions of the thymus. Reyes, R.A., Canfield, D.R., Esser, U., Adamson, L.A., Brown, C.R., Cheng-Mayer, C., Gardner, M.B., Harouse, J.M., Luciw, P.A. J. Virol. (2004) [Pubmed]
  9. Rapid progression to simian AIDS can be accompanied by selection of CD4-independent gp120 variants with impaired ability to bind CD4. Ryzhova, E., Whitbeck, J.C., Canziani, G., Westmoreland, S.V., Cohen, G.H., Eisenberg, R.J., Lackner, A., González-Scarano, F. J. Virol. (2002) [Pubmed]
  10. Phenotypic analysis of malignant lymphoma in simian immunodeficiency virus infection using anti-human antibodies. Ramsay, A.D., Giddings, J., Baskerville, A., Cranage, M.P. J. Pathol. (1991) [Pubmed]
  11. Toxicity and efficacy of 2',3'-dideoxycytidine in clinical trials of pigtailed macaques infected with simian retrovirus type 2. Tsai, C.C., Follis, K.E., Yarnall, M., Blakley, G.A. Antimicrob. Agents Chemother. (1989) [Pubmed]
  12. Quinolinic acid and lymphocyte subsets in the intrathecal compartment as biomarkers of SIV infection and simian AIDS. Coe, C.L., Reyes, T.M., Pauza, C.D., Reinhard, J.F. AIDS Res. Hum. Retroviruses (1997) [Pubmed]
  13. Chemotactic competence of neutrophils from neonatal calves. Functional comparison with neutrophils from adult cattle. Zwahlen, R.D., Roth, D.R. Inflammation (1990) [Pubmed]
  14. Influence of anti-inflammatory drugs on adhesion of neutrophils to endothelial cells cultured on microcarriers: a novel in vitro system as an alternative to animal experimentation. Zwahlen, R.D., Holden, W.J., Wyder-Walther, M., Holub, M., Moiola, F. Zentralblatt für Veterinärmedizin. Reihe A. (1994) [Pubmed]
  15. Interactions of opioid and chemokine receptors: oligomerization of mu, kappa, and delta with CCR5 on immune cells. Suzuki, S., Chuang, L.F., Yau, P., Doi, R.H., Chuang, R.Y. Exp. Cell Res. (2002) [Pubmed]
  16. Could Nef and Vpr proteins contribute to disease progression by promoting depletion of bystander cells and prolonged survival of HIV-infected cells? Azad, A.A. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  17. T-tropic human immunodeficiency virus (HIV) type 1 Nef protein enters human monocyte-macrophages and induces resistance to HIV replication: a possible mechanism of HIV T-tropic emergence in AIDS. Alessandrini, L., Santarcangelo, A.C., Olivetta, E., Ferrantelli, F., d'Aloja, P., Pugliese, K., Pelosi, E., Chelucci, C., Mattia, G., Peschle, C., Verani, P., Federico, M. J. Gen. Virol. (2000) [Pubmed]
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