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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Cercocebus atys

 
 
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Disease relevance of Cercocebus atys

 

High impact information on Cercocebus atys

  • Seven SIV CTL epitopes were identified in five sooty mangabeys: one in Gag and three each in Nef and Envelope (Env) [4].
  • Sooty mangabeys bred to homozygosity for the deletion allele will be useful for experimental studies on the context-dependent role of CCR5 in host defense and microbial pathogenesis [5].
  • Here, we report the first molecular epidemiological survey of SIVsmm in a community of approximately 120 free-ranging sooty mangabeys in the Taï Forest, Côte d'Ivoire [6].
  • SIVrcmNG411 carried a vpx gene in addition to vpr, suggesting a common evolutionary ancestor with SIVsm (from sooty mangabeys) [7].
  • These results suggest that STRL33 is not a relevant coreceptor in the SIV/macaque model but may play a role in SIV replication and transmission in naturally infected sooty mangabeys [8].
 

Biological context of Cercocebus atys

 

Associations of Cercocebus atys with chemical compounds

 

Gene context of Cercocebus atys

  • True primary strains of SIVsm, obtained from the naturally infected simian host, the sooty mangabey, use simian and human CCR5 in a strongly CD4 dependent manner [13].
  • This is also the first report documenting the occurrence of natural CD86 variants with deleted transmembrane domains, found both in sooty mangabeys and baboon RNA samples [14].
  • Finally, upon sequencing several clones from individual monkeys, a low degree of sequence variation (nucleotide substitutions, deletions, and insertions) was found within the same animal, and in case of sooty mangabeys two distict populations of CD4 molecules were present within three of four individuals [15].
  • Sequence polymorphisms in CCR5 found in four sooty mangabeys did not alter viral entry [16].
  • The STLV-I(sm) strain obtained from the sooty mangabey was transmitted to normal macaque and mangabey PBMC and was shown to be unique by sequencing of the entire env gene [17].

References

  1. Primary sooty mangabey simian immunodeficiency virus and human immunodeficiency virus type 2 nef alleles modulate cell surface expression of various human receptors and enhance viral infectivity and replication. Münch, J., Schindler, M., Wildum, S., Rücker, E., Bailer, N., Knoop, V., Novembre, F.J., Kirchhoff, F. J. Virol. (2005) [Pubmed]
  2. Uracil DNA glycosylase specifically interacts with Vpr of both human immunodeficiency virus type 1 and simian immunodeficiency virus of sooty mangabeys, but binding does not correlate with cell cycle arrest. Selig, L., Benichou, S., Rogel, M.E., Wu, L.I., Vodicka, M.A., Sire, J., Benarous, R., Emerman, M. J. Virol. (1997) [Pubmed]
  3. Rates of amino acid change in the envelope protein correlate with pathogenicity of primate lentiviruses. Shpaer, E.G., Mullins, J.I. J. Mol. Evol. (1993) [Pubmed]
  4. Identification of multiple simian immunodeficiency virus (SIV)-specific CTL epitopes in sooty mangabeys with natural and experimentally acquired SIV infection. Kaur, A., Yang, J., Hempel, D., Gritz, L., Mazzara, G.P., McClure, H., Johnson, R.P. J. Immunol. (2000) [Pubmed]
  5. Parallel evolution of CCR5-null phenotypes in humans and in a natural host of simian immunodeficiency virus. Palacios, E., Digilio, L., McClure, H.M., Chen, Z., Marx, P.A., Goldsmith, M.A., Grant, R.M. Curr. Biol. (1998) [Pubmed]
  6. Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2. Santiago, M.L., Range, F., Keele, B.F., Li, Y., Bailes, E., Bibollet-Ruche, F., Fruteau, C., Noë, R., Peeters, M., Brookfield, J.F., Shaw, G.M., Sharp, P.M., Hahn, B.H. J. Virol. (2005) [Pubmed]
  7. Characterization of novel simian immunodeficiency viruses from red-capped mangabeys from Nigeria (SIVrcmNG409 and -NG411). Beer, B.E., Foley, B.T., Kuiken, C.L., Tooze, Z., Goeken, R.M., Brown, C.R., Hu, J., St Claire, M., Korber, B.T., Hirsch, V.M. J. Virol. (2001) [Pubmed]
  8. Simian immunodeficiency virus utilizes human and sooty mangabey but not rhesus macaque STRL33 for efficient entry. Pöhlmann, S., Lee, B., Meister, S., Krumbiegel, M., Leslie, G., Doms, R.W., Kirchhoff, F. J. Virol. (2000) [Pubmed]
  9. Glycosylation of the envelope glycoprotein gp130 of simian immunodeficiency virus from sooty mangabey (Cercocebus atys). Holschbach, C., Schneider, J., Geyer, H. Biochem. J. (1990) [Pubmed]
  10. Molecular cloning and expression of rhesus macaque and sooty mangabey interleukin 16: biologic activity and effect on simian immunodeficiency virus infection and/or replication. Lee, M.E., Adams, J.W., Villinger, F., Brar, S.S., Meadows, M., Bucur, S.Z., Lackey, D.A., Brice, G.T., Cruikshank, W.W., Ansari, A.A., Hillyer, C.D. AIDS Res. Hum. Retroviruses (1998) [Pubmed]
  11. Relation between phylogeny of African green monkey CD4 genes and their respective simian immunodeficiency virus genes. Fomsgaard, A., Müller-Trutwin, M.C., Diop, O., Hansen, J., Mathiot, C., Corbet, S., Barré-Sinoussi, F., Allan, J.S. J. Med. Primatol. (1997) [Pubmed]
  12. Developmental patterns of serum luteinizing hormone, gonadal and adrenal steroids in the sooty mangabey (Cercocebus atys). Mann, D.R., Castracane, V.D., McLaughlin, F., Gould, K.G., Collins, D.C. Biol. Reprod. (1983) [Pubmed]
  13. The function of simian chemokine receptors in the replication of SIV. Marx, P.A., Chen, Z. Semin. Immunol. (1998) [Pubmed]
  14. Cloning, sequencing, and homology analysis of nonhuman primate Fas/Fas-ligand and co-stimulatory molecules. Villinger, F., Bostik, P., Mayne, A., King, C.L., Genain, C.P., Weiss, W.R., Ansari, A.A. Immunogenetics (2001) [Pubmed]
  15. Cloning and sequences of primate CD4 molecules: diversity of the cellular receptor for simian immunodeficiency virus/human immunodeficiency virus. Fomsgaard, A., Hirsch, V.M., Johnson, P.R. Eur. J. Immunol. (1992) [Pubmed]
  16. Primary SIVsm isolates use the CCR5 coreceptor from sooty mangabeys naturally infected in west Africa: a comparison of coreceptor usage of primary SIVsm, HIV-2, and SIVmac. Chen, Z., Gettie, A., Ho, D.D., Marx, P.A. Virology (1998) [Pubmed]
  17. Isolation of sooty mangabey simian T-cell leukemia virus type I [STLV-I(sm)] and characterization of a mangabey T-cell line coinfected with STLV-I(sm) and simian immunodeficiency virus SIVsmmPBj14. Fultz, P.N., Su, L., May, P., West, J.T. Virology (1997) [Pubmed]
 
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