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MeSH Review


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Disease relevance of Sporotrichosis


High impact information on Sporotrichosis


Chemical compound and disease context of Sporotrichosis


Anatomical context of Sporotrichosis


Gene context of Sporotrichosis

  • The involvement of interferon-gamma (IFN-gamma) and inducible nitric oxide synthase (iNOS) in the granuloma formation of sporotrichosis is less known [16].
  • In contrast, the presence of Th2 response began in the 5th week, suggesting the participation of humoral immune response in advanced stages of sporotrichosis [17].
  • We report a case of disseminated sporotrichosis in a 49-year-old man who was treated with multiple immunosuppressants, including tumor necrosis factor (TNF)-alpha antagonists (etanercept and infliximab), for presumed inflammation arthritis [18].
  • A case of lymphocutaneous sporotrichosis that had developed from the dorsum nasi to the left buccal region of a 65-year-old woman was treated with itraconazole 100 mg day-1 [19].

Analytical, diagnostic and therapeutic context of Sporotrichosis


  1. Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group. Sharkey-Mathis, P.K., Kauffman, C.A., Graybill, J.R., Stevens, D.A., Hostetler, J.S., Cloud, G., Dismukes, W.E. Am. J. Med. (1993) [Pubmed]
  2. Endemic mycoses: a treatment update. Lortholary, O., Denning, D.W., Dupont, B. J. Antimicrob. Chemother. (1999) [Pubmed]
  3. Systemic sporotrichosis treated with itraconazole. Winn, R.E., Anderson, J., Piper, J., Aronson, N.E., Pluss, J. Clin. Infect. Dis. (1993) [Pubmed]
  4. Disseminated cutaneous sporotrichosis in an AIDS patient receiving maintenance therapy with fluconazole for previous cryptococcal meningitis. Goldani, L.Z., Aquino, V.R., Dargél, A.A. Clin. Infect. Dis. (1999) [Pubmed]
  5. In vitro antifungal spectrum of itraconazole and treatment of systemic mycoses with old and new antimycotic agents. Van Cutsem, J. Chemotherapy. (1992) [Pubmed]
  6. Spook house sporotrichosis. A point-source outbreak of sporotrichosis associated with hay bale props in a Halloween haunted-house. Dooley, D.P., Bostic, P.S., Beckius, M.L. Arch. Intern. Med. (1997) [Pubmed]
  7. Intra-articular amphotericin B treatment of Sporothrix schenckii arthritis. Downs, N.J., Hinthorn, D.R., Mhatre, V.R., Liu, C. Arch. Intern. Med. (1989) [Pubmed]
  8. Synthesis of melanin-like pigments by Sporothrix schenckii in vitro and during mammalian infection. Morris-Jones, R., Youngchim, S., Gomez, B.L., Aisen, P., Hay, R.J., Nosanchuk, J.D., Casadevall, A., Hamilton, A.J. Infect. Immun. (2003) [Pubmed]
  9. Efficacies of four antifungal agents in experimental murine sporotrichosis. Kan, V.L., Bennett, J.E. Antimicrob. Agents Chemother. (1988) [Pubmed]
  10. Treatment of cutaneous sporotrichosis with one daily dose of potassium iodide. Cabezas, C., Bustamante, B., Holgado, W., Begue, R.E. Pediatr. Infect. Dis. J. (1996) [Pubmed]
  11. Treatment of lymphocutaneous and visceral sporotrichosis with fluconazole. Kauffman, C.A., Pappas, P.G., McKinsey, D.S., Greenfield, R.A., Perfect, J.R., Cloud, G.A., Thomas, C.J., Dismukes, W.E. Clin. Infect. Dis. (1996) [Pubmed]
  12. Successful treatment of disseminated cutaneous sporotrichosis with ketoconazole. Cullen, S.I., Mauceri, A.A., Warner, N. J. Am. Acad. Dermatol. (1992) [Pubmed]
  13. Treatment of cutaneous sporotrichosis with terbinafine. Hull, P.R., Vismer, H.F. Br. J. Dermatol. (1992) [Pubmed]
  14. Disseminate sporotrichosis of skin and bone cured with 5-fluorocytosine: Photosensitivity as a complication. Shelley, W.B., Sica, P.A. J. Am. Acad. Dermatol. (1983) [Pubmed]
  15. Effect of immunization and potassium iodide on polymorphonuclear leukocyte chemiluminescence in experimental murine sporotrichosis. Shimizu, T., Hiruma, M., Akiyama, M., Kukita, A., Tsuru, S. Mycoses (1989) [Pubmed]
  16. Immunohistochemical detection of interferon-gamma-producing cells in granuloma formation of sporotrichosis. Koga, T., Duan, H., Furue, M. Med. Mycol. (2002) [Pubmed]
  17. Influence of Th1/Th2 cytokines and nitric oxide in murine systemic infection induced by Sporothrix schenckii. Maia, D.C., Sassá, M.F., Placeres, M.C., Carlos, I.Z. Mycopathologia (2006) [Pubmed]
  18. Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonists. Gottlieb, G.S., Lesser, C.F., Holmes, K.K., Wald, A. Clin. Infect. Dis. (2003) [Pubmed]
  19. Case report. Sporotrichosis successfully treated with itraconazole in Japan. Noguchi, H., Hiruma, M., Kawada, A. Mycoses (1999) [Pubmed]
  20. Immunoblot analysis of antibody responses to Sporothrix schenckii. Scott, E.N., Muchmore, H.G. J. Clin. Microbiol. (1989) [Pubmed]
  21. Chemotherapy for the systemic mycoses: the prelude to ketoconazole. Utz, J.P. Rev. Infect. Dis. (1980) [Pubmed]
  22. Ultrastructure of Sporothrix schenckii treated with iodine-potassium iodide solution. Hiruma, M., Kagawa, S. Mycopathologia (1987) [Pubmed]
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