Disease relevance of Sporothrix

• Granulomatous tenosynovitis and carpal tunnel syndrome caused by Sporothrix schenckii [1].
• Sera from 40 patients with sporotrichosis demonstrated Sporothrix immunoglobulin G antibody by ELISA with titers between 128 and 65,200 [2].
• Fungemia caused by an amphotericin B-resistant isolate of Sporothrix schenckii. Successful treatment with itraconazole [3].
• Presence of a pertussis toxin-sensitive G protein alpha subunit in Sporothrix schenckii [4].
• An extract obtained from the mycelium of Paecilomyces tenuipes RCEF 0275 showed moderate MAO inhibitory activity, whereas extracts of Sporothrix chondracris RCEF 0187 antagonized NMDA receptor mediated cell toxicity [5].

High impact information on Sporothrix

• Intra-articular amphotericin B treatment of Sporothrix schenckii arthritis [6].
• Involvement of fungal cell wall components in adhesion of Sporothrix schenckii to human fibronectin [7].
• The MICs of amphotericin B, fluconazole, itraconazole, miconazole, and ketoconazole were determined in six centers by both macro- and microdilution tests for 25 isolates of Aspergillus flavus, Aspergillus fumigatus, Pseudallescheria boydii, Rhizopus arrhizus, and Sporothrix schenckii [8].
• Polarimetry and 13C n.m.r. show that the hydrolyses of beta-D-glucopyranosyl fluoride by beta(1-->3)-glucanases from Phanerochaete chrysosporium and Sporotrichum dimorphosporum have opposite stereochemistries [9].
• Cryptococcus neoformans, Candida albicans, and Saccharomyces cerevisiae, as well as Histoplasma capsulatum and Sporotrichum schenckii (in their yeast phases), bound specifically to lactosylceramide (Gal beta 1-4Glc beta 1-1Cer), as measured by overlaying glycosphingolipid chromatograms with 125I-labeled organisms [10].

Chemical compound and disease context of Sporothrix

• Sporotrichosis is the most common subcutaneous mycosis in South America. Classic infection is associated with traumatic inoculation of soil, vegetables, and organic matter contaminated with Sporothrix schenckii [11].

Biological context of Sporothrix

• Oxidative decarboxylation of vanillic acid by Sporotrichum pulverulentum [12].

Anatomical context of Sporothrix

• The ingestion by thioglycolate-elicited mouse peritoneal macrophages of yeast forms of two strains of Sporothrix schenckii was studied [13].
• Three murine monoclonal antibodies (Mabs) were raised against a cytoplasmic antigen of the yeast phase of the pathogenic fungus Sporothrix schenckii using a modification of standard hybridoma technology incorporating the immunosuppressive drug cyclophosphamide [14].
• The effect of the supernatants obtained from the liquid culture medium of Sporothrix schenkii and Candida albicans on the generation of superoxide anion (O2- and hydroxyl radicals OH., the elements of reactive oxygen species (ROS), and chemoluminescence (CL), a measure of several ROS, by polymorphonuclear leukocytes (PMNs) was examined [15].
• Administration of potassium iodide to normal volunteers does not increase killing of Sporothrix schenckii by their neutrophils or monocytes [16].

Associations of Sporothrix with chemical compounds

• Some properties of cellobiose oxidase from the white-rot fungus Sporotrichum pulverulentum [17].
• Galactose-containing polysaccharides from the human pathogens Sporothrix schenckii and Ceratocystis stenoceras [18].
• Resolution, purification and some properties of the multiple forms of cellobiose quinone dehydrogenase from the white-rot fungus Sporotrichum pulverulentum [19].
• Isolates of Cryptococcus neoformans and Sporothrix schenckii appeared to be less susceptible, with many isolates being resistant to less than or equal to 1.56 micrograms of ketoconazole/ml [20].
• A rhamnomannan containing single-unit alpha-L-rhamnopyranose side chains was identified in isolated conidia from Sporothrix schenckii [21].

Gene context of Sporothrix

• Influence of Th1/Th2 cytokines and nitric oxide in murine systemic infection induced by Sporothrix schenckii [22].
• Here we report studies of the adhesion of Sporothrix schenckii to the extracellular protein fibronectin (Fn) [7].
• Intracellular quinone reduction in Sporotrichum pulverulentum by a NAD(P)H:quinone oxidoreductase: possible role in vanillic acid catabolism [23].
• CDH contains one heme b and one FAD per molecule and oxidizes cellobiose to cellobionolactone in the presence of cytochrome c. In this report, a thermostable CDH from the thermophilic ascomycete Sporotrichum thermophile has been purified, cloned, and characterized [24].
• The adherence of Sporothrix schenckii yeast cells to several extracellular matrix (ECM) components has already been demonstrated, but the mechanisms of these interactions remained to be defined [25].

References