Disease relevance of Aortic Diseases

• PURPOSE: Tumor necrosis factor (TNF), interleukin 1 (IL-1), and matrix metalloproteases have been noted to be elevated in human abdominal aortic aneurysms (AAAs) as compared with normal and occlusive aortic disease [1].

High impact information on Aortic Diseases

• Dipyridamole imaging is particularly useful for preoperative risk stratification in patients undergoing surgery for peripheral vascular or aortic disease [2].
• PURPOSE: To evaluate gadolinium-enhanced three-dimensional magnetic resonance (MR) angiography for thoracic aortic disease and to compare this technique with conventional thoracic MR imaging [3].
• The aim of this study is to elucidate the role of angiotensin II signaling in THE pathogenesis of aortic diseases associated with CMD [4].
• CONCLUSION: Differential expression of plasminogen activators within the arterial wall may contribute to the unique pathogenesis of aneurysmal and occlusive aortic disease [5].
• Increased ICAM-1 expression in aortic disease [6].

Chemical compound and disease context of Aortic Diseases

• The magnitude of this systemic response is unlikely to alter the nature or distribution of cholesterol-induced atherosclerosis but may have an important influence on the development of aortic disease produced by prolonged feeding of high-fat, cholesterol-free diets [7].
• Differential expression of prostaglandin E2 and interleukin-6 in occlusive and aneurysmal aortic disease [8].
• The study on the whole depicted the ability of Se to inhibit the onset of progression of aortic disease and hence has relevance to its therapeutic potential [9].
• Further studies are needed to confirm the role of Hcy in aortic disease and the usefulness of including Hcy determination in the clinical evaluation of these patients [10].
• Twenty-six patients were treated by surgical procedure for aortic diseases with use of Gelatin Resorcin Formalin (GRF) glue [11].

Anatomical context of Aortic Diseases

• Smooth muscle cell regulation of elastin metabolism may be important in determining why some patients have AAA and others have occlusive aortic disease develop [12].

Gene context of Aortic Diseases

• Recent data suggest that MMP-2 and MMP-9 may also play a role in thoracic aortic disease [13].
• Elastase modified by alpha 1-antitrypsin (elastase/alpha 1-antitrypsin) increased significantly as the type of aortic disease changed from occlusive to aneurysmal disease [14].
• The purpose of this study was to analyze the inflammatory cytokines interleukin-6 (IL-6) and prostaglandin E2 (PGE2) in aortic disease and compare AAA with AIOD, as well as to compare both with normal aorta [8].
• Plasma endothelin in patients with acute aortic disease [15].
• Multivariable analysis of all patients revealed increased mortality with severe atheromatous aortic disease (p = 0.001), COPD (p = 0.002), and urgent operation (p = 0.02) [16].

References