Disease relevance of Brain Chemistry

• Most studies on MPTP/MPP+ toxicity and protection by ALCAR have focused on in vivo brain chemistry and in vitro neuronal culture studies [1].

Psychiatry related information on Brain Chemistry

• Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy study [2].
• Effect of lithium and other alkali metals on brain chemistry and behavior. II. Intracranial self-stimulation behavior [3].
• Pharmacological blockade of the (NMDA) receptor at critical stages of brain development may have long-lasting effects on brain chemistry and on animal behavior [4].

High impact information on Brain Chemistry

• Consequently, we assessed the effects of tamoxifen and estrogen on the brain chemistry of elderly women [5].
• CONCLUSIONS: These data suggest that it is the balance between HVA and 5-HIAA rather than their absolute levels which is associated with brain morphology and that this relationship between brain chemistry and morphology may be characteristic of the normal range of functioning for these systems [6].
• Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder [7].
• Indoleamine 2,3-dioxygenase (IDO), the first and rate-limiting enzyme in tryptophan catabolism in extrahepatic tissues, can lead to neurotoxicity through the generation of quinolinic acid and immunosuppression and can alter brain chemistry via depletion of tryptophan [8].
• There is now considerable evidence from basic neuroscience that estrogen influences aspects of brain chemistry and brain morphology known to be important for memory functions [9].

Biological context of Brain Chemistry

• Abnormalities of total brain volume, gray and white matter volumes, brain chemistry, serotonin synthesis, and brain electrophysiology are evident by early childhood [10].

Anatomical context of Brain Chemistry

• In the cerebrospinal fluid (CSF), glutamine remained low and lysine elevated, showing the treatment had not normalized brain chemistry [11].

Associations of Brain Chemistry with chemical compounds

• Effects of dietary choline on memory and brain chemistry in aged mice [12].
• Effect of lithium and other alkali metals on brain chemistry and behavior. I. Glutamic acid and GABA in brain regions [13].
• These findings replicate and extend previous reports that continuous drug administration induces long-lasting alterations in brain chemistry, but indicate that continuous cocaine has enduring effects on different neurochemical systems from continuous amphetamine [14].
• The behavioral results are discussed in terms of drug-induced changes in brain chemistry and indicate a possible role for serotonin in the mediation of maternal aggressive behavior of mice [15].
• To address this possibility, we evaluated changes in brain chemistry that were associated with oral creatine (Cr) administration [16].

Gene context of Brain Chemistry

• Thus, the changes in brain chemistry caused by chronic BBS were not due to direct effects of BBS but may be mediated through its metabolites or CCK release [17].
• Regulation of CSF cortisol is not well understood, and its relationship to other brain chemistries is unclear [18].
• Such evidence is important not only because it sheds light on the relevance of human CSF findings to brain chemistry but also because it may be used to study transmitter metabolism in the brain of the living rat and provides quantitative data on the role of the CSF in the removal of the metabolites from the brain [19].

References