Gene Review:
POLH - polymerase (DNA directed), eta
Homo sapiens
Synonyms:
DNA polymerase eta, RAD30, RAD30 homolog A, RAD30A, XP-V, ...
- A role for polymerase eta in the cellular tolerance to cisplatin-induced damage. Albertella, M.R., Green, C.M., Lehmann, A.R., O'Connor, M.J. Cancer Res. (2005)
- Mutations in DNA polymerase eta are not detected in squamous cell carcinoma of the skin. Glick, E., White, L.M., Elliott, N.A., Berg, D., Kiviat, N.B., Loeb, L.A. Int. J. Cancer (2006)
- Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant. Cleaver, J.E., Afzal, V., Feeney, L., McDowell, M., Sadinski, W., Volpe, J.P., Busch, D.B., Coleman, D.M., Ziffer, D.W., Yu, Y., Nagasawa, H., Little, J.B. Cancer Res. (1999)
- Association between DNA repair-deficiency and high level of p53 mutations in melanoma of Xeroderma pigmentosum. Spatz, A., Giglia-Mari, G., Benhamou, S., Sarasin, A. Cancer Res. (2001)
- Low fidelity DNA synthesis by human DNA polymerase-eta. Matsuda, T., Bebenek, K., Masutani, C., Hanaoka, F., Kunkel, T.A. Nature (2000)
- The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta. Masutani, C., Kusumoto, R., Yamada, A., Dohmae, N., Yokoi, M., Yuasa, M., Araki, M., Iwai, S., Takio, K., Hanaoka, F. Nature (1999)
- Xeroderma pigmentosum variant (XP-V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity. Masutani, C., Araki, M., Yamada, A., Kusumoto, R., Nogimori, T., Maekawa, T., Iwai, S., Hanaoka, F. EMBO J. (1999)
- The mechanism of nucleotide incorporation by human DNA polymerase eta differs from that of the yeast enzyme. Washington, M.T., Johnson, R.E., Prakash, L., Prakash, S. Mol. Cell. Biol. (2003)
- Role of DNA polymerase zeta in the bypass of a (6-4) TT photoproduct. Johnson, R.E., Haracska, L., Prakash, S., Prakash, L. Mol. Cell. Biol. (2001)
- The role of DNA polymerase eta in translesion synthesis past platinum-DNA adducts in human fibroblasts. Bassett, E., King, N.M., Bryant, M.F., Hector, S., Pendyala, L., Chaney, S.G., Cordeiro-Stone, M. Cancer Res. (2004)
- Cancer protection in xeroderma pigmentosum variant (XP-V). Somos, S., Farkas, B., Schneider, I. Anticancer Res. (1999)
- Nucleotide excision repair- and polymerase eta-mediated error-prone removal of mitomycin C interstrand cross-links. Zheng, H., Wang, X., Warren, A.J., Legerski, R.J., Nairn, R.S., Hamilton, J.W., Li, L. Mol. Cell. Biol. (2003)
- Genome sequence and splice site analysis of low-fidelity DNA polymerases H and I involved in replication of damaged DNA. Cleaver, J.E., Collins, C., Ellis, J., Volik, S. Genomics (2003)
- Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota. Vaisman, A., Frank, E.G., Iwai, S., Ohashi, E., Ohmori, H., Hanaoka, F., Woodgate, R. DNA Repair (Amst.) (2003)
- DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation. Liu, G., Chen, X. Mol. Cell. Biol. (2006)
- Molecular genetics of Xeroderma pigmentosum variant. Gratchev, A., Strein, P., Utikal, J., Sergij, G. Exp. Dermatol. (2003)
- Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Bienko, M., Green, C.M., Crosetto, N., Rudolf, F., Zapart, G., Coull, B., Kannouche, P., Wider, G., Peter, M., Lehmann, A.R., Hofmann, K., Dikic, I. Science (2005)
- hRAD30 mutations in the variant form of xeroderma pigmentosum. Johnson, R.E., Kondratick, C.M., Prakash, S., Prakash, L. Science (1999)
- DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes. Zeng, X., Winter, D.B., Kasmer, C., Kraemer, K.H., Lehmann, A.R., Gearhart, P.J. Nat. Immunol. (2001)
- DNA polymerase eta is involved in hypermutation occurring during immunoglobulin class switch recombination. Faili, A., Aoufouchi, S., Weller, S., Vuillier, F., Stary, A., Sarasin, A., Reynaud, C.A., Weill, J.C. J. Exp. Med. (2004)
- Xeroderma pigmentosum variant: generation and characterization of fibroblastic cell lines transformed with SV40 large T antigen. King, S.A., Wilson, S.J., Farber, R.A., Kaufmann, W.K., Cordeiro-Stone, M. Exp. Cell Res. (1995)
- The role of DNA polymerase iota in UV mutational spectra. Choi, J.H., Besaratinia, A., Lee, D.H., Lee, C.S., Pfeifer, G.P. Mutat. Res. (2006)
- Mammalian translesion DNA synthesis across an acrolein-derived deoxyguanosine adduct. Participation of DNA polymerase eta in error-prone synthesis in human cells. Yang, I.Y., Miller, H., Wang, Z., Frank, E.G., Ohmori, H., Hanaoka, F., Moriya, M. J. Biol. Chem. (2003)
- A human DNA polymerase eta complex containing Rad18, Rad6 and Rev1; proteomic analysis and targeting of the complex to the chromatin-bound fraction of cells undergoing replication fork arrest. Yuasa, M.S., Masutani, C., Hirano, A., Cohn, M.A., Yamaizumi, M., Nakatani, Y., Hanaoka, F. Genes Cells (2006)
- Physical and functional interactions of human DNA polymerase eta with PCNA. Haracska, L., Johnson, R.E., Unk, I., Phillips, B., Hurwitz, J., Prakash, L., Prakash, S. Mol. Cell. Biol. (2001)
- High mobility of flap endonuclease 1 and DNA polymerase eta associated with replication foci in mammalian S-phase nucleus. Solovjeva, L., Svetlova, M., Sasina, L., Tanaka, K., Saijo, M., Nazarov, I., Bradbury, M., Tomilin, N. Mol. Biol. Cell (2005)
- DNA replication arrest in XP variant cells after UV exposure is diverted into an Mre11-dependent recombination pathway by the kinase inhibitor wortmannin. Limoli, C.L., Laposa, R., Cleaver, J.E. Mutat. Res. (2002)
- Clinical characteristics of three patients with UVs syndrome, a photosensitive disorder with defective DNA repair. Itoh, T., Yamaizumi, M., Ichihashi, M., Hiro-Oka, M., Matsui, T., Matsuno, M., Ono, T. Br. J. Dermatol. (1996)
- Translesion replication in cisplatin-treated xeroderma pigmentosum variant cells is also caffeine-sensitive: features of the error-prone DNA polymerase(s) involved in UV-mutagenesis. Yamada, K., Takezawa, J., Ezaki, O. DNA Repair (Amst.) (2003)
- Adenovirus mediated transduction of the human DNA polymerase eta cDNA. Lima-Bessa, K.M., Chiganças, V., Stary, A., Kannouche, P., Sarasin, A., Armelini, M.G., de Fátima Jacysyn, J., Amarante-Mendes, G.P., Cordeiro-Stone, M., Cleaver, J.E., Menck, C.F. DNA Repair (Amst.) (2006)