Disease relevance of Gallbladder Emptying

• CONCLUSIONS--Prolongation of intestinal transit and impaired gall bladder emptying may contribute to lithogenic changes in bile composition and gall stone formation in patients receiving long term octreotide [1].
• Effect of octreotide on fasting gall bladder emptying, antroduodenal motility, and motilin release in acromegaly [2].

High impact information on Gallbladder Emptying

• The gallbladder-emptying response to exogenous cholecystokinin increased significantly in patients who had undergone truncal vagotomy [3].
• Fasting CCK levels were not affected whereas CCK induced gall bladder emptying increased during bezafibrate (+29%; p<0.001) and tended to increase on fish oil therapy (+13%; p=0.07) [4].
• BACKGROUND: Octreotide inhibits gall bladder emptying and prolongs intestinal transit [5].
• Effects of cisapride on gall bladder emptying, intestinal transit, and serum deoxycholate: a prospective, randomised, double blind, placebo controlled trial [5].
• Motilin induces gall bladder emptying and antral contractions in the fasted state in humans [6].

Chemical compound and disease context of Gallbladder Emptying

• To evaluate whether the extent of postprandial gall bladder emptying is correlated with gall bladder fasting volume, gall bladder motility was studied in 56 patients with cholesterol gall stone and 19 control patients [7].

Biological context of Gallbladder Emptying

• The degree of gall bladder volume reduction during motilin infusion mimicked gall bladder emptying preceding antral phase III activity of the migrating motor complex in humans [6].
• RESULTS: Levosulpiride, with respect to placebo, accelerated the mean gastric half-emptying time of liquids (P < 0.05), gastric emptying (P < 0.001 at 180 min; P < 0.05 at 240 min), and gall-bladder emptying (P < 0.05 at 60 and 120 min) emptying after a solid-liquid mixed meal [8].

Anatomical context of Gallbladder Emptying

• SR 27897 was also very active (ED50 = 27 micrograms/kg p.o.) in the gall bladder emptying protocol with egg yolk as an inducer of endogenous CCK release [9].
• Egg yolk-induced gall-bladder emptying in mice was used to investigate the effect of glibenclamide and minoxidil (ATP-dependent K(+)-channel modulators) on biliary tract effects of morphine [10].

Associations of Gallbladder Emptying with chemical compounds

• This study evaluates the effects of the specific cholecystokinin receptor antagonist loxiglumide on gall-bladder emptying after a meal or after intravenous infusion of caerulein in humans [11].
• Glyceryl trinitrate also significantly impaired gall bladder emptying between five and 40 minutes postprandially [12].
• In humans, no effect has been shown, but erythromycin, a motilin receptor agonist, induces gall bladder emptying [6].
• MEASUREMENTS: At the beginning of the study and after levosulpiride or placebo treatment, gall-bladder emptying was measured ultrasonically by evaluating the gall-bladder volume in basal conditions and every 15 min for 90 min after the ingestion of a standard meal [13].
• AIM: To study whether orlistat, by lipase inhibition, impairs gall-bladder emptying, thus further predisposing weight-losing obese subjects to gallstone formation [14].

Gene context of Gallbladder Emptying

• This is probably related to profound suppression of cholecystokinin release and gall-bladder emptying [15].
• MgS04 activates the ileal brake mechanism only in the fed state, with peptide YY release and inhibition of gall-bladder emptying [16].
• Meal induced gall bladder emptying was studied in patients with PSC, patients with PBC, and healthy controls [17].
• Stress-induced inhibition of gall bladder emptying could affect energy assimilation such that subordinate animals would not be able to effectively convert energy-rich food into mass gain [18].
• The effect of two different single oral doses of loxiglumide (CR 1505, CAS 107097-80-3) on gall-bladder emptying induced by a 550-cal standard mixed meal in 6 healthy volunteers was studied [19].

References