Disease relevance of Typhus, Endemic Flea-Borne

• Sera from patients suspected of having rickettsial infections were tested in the complement fixation test with antigens prepared from the rickettsiae of Rocky Mountain spotted fever (SF), rickettsial pox (RP), murine typhus, epidemic typhus, and from Rickettsia canada (RC) [1].
• This paper reports the molecular and functional analysis of the putative secA gene, an essential component of the Sec-dependent protein secretion pathway, from Rickettsia rickettsii and Rickettsia typhi, the aetiological agents of Rocky Mountain spotted fever and murine typhus, respectively [2].
• Serum cross-adsorption studies and Western blotting were performed on sera from 12 selected patients, 5 with murine typhus, 5 with epidemic typhus, and 2 suffering from typhus of undetermined etiology [3].
• In the years 1975-1984, 132 patients with rickettsial Mediterranean spotted fever and murine typhus were treated with chloramphenicol or tetracycline [4].
• The sera from two patients with murine typhus reacted with whole cells of Rickettsia prowazekii, R. typhi, and Proteus vulgaris OX19, and with lipopolysaccharides (LPS) from the spotted fever group rickettsia strain TT-118 and P. vulgaris OX19 in the enzyme-linked immunosorbent assay [5].

High impact information on Typhus, Endemic Flea-Borne

• From 1980 through 1984, a total of 200 cases of murine typhus were reported in Texas. All cases were confirmed by the indirect fluorescent antibody assay or latex agglutination test [6].
• Use of enzyme-linked immunosorbent assay techniques with cross-reacting human sera in diagnosis of murine typhus and spotted fever [7].
• The symptoms, effectiveness of tetracycline, and presence of a large rat population raised the suspicion of murine typhus [8].
• Murine typhus poorly responsive to ciprofloxacin: a case report [9].
• The occurrence of relapse in eight of the 16 patients treated with chloramphenicol (seven cases of murine typhus and one case of spotted fever) was striking, particularly since none occurred in 86 patients treated with tetracycline hydrochloride (p less than 0.01) [10].

Chemical compound and disease context of Typhus, Endemic Flea-Borne

• Ciprofloxacin treatment of murine typhus [11].
• METHODS: A retrospective analysis of the clinical history, photography and fluorescein angiography of two patients with acute murine typhus with ocular involvement was conducted [12].
• Murine typhus is endemic in many South East Asian countries but it has not been reported from the island of Borneo [13].
• Doxycycline has emerged as the best treatment for murine typhus, epidemic typhus, and scrub typhus [14].

Biological context of Typhus, Endemic Flea-Borne

• In six out of these 8 sera, antibodies to Rickettsia typhi, the cause of murine typhus, were detected possibly as a cross-reaction with some "newly detected" rickettsia circulating in this part of Europe, most likely Rickettsia slovaca [15].

Analytical, diagnostic and therapeutic context of Typhus, Endemic Flea-Borne

• Relapse of rickettsial Mediterranean spotted fever and murine typhus after treatment with chloramphenicol [4].

References