Disease relevance of Ovarian Failure, Premature

• Moreover, radiation-induced oocyte loss in adult wild-type female mice, the event that drives premature ovarian failure and infertility in female cancer patients, was completely prevented by in vivo therapy with sphingosine-1-phosphate [1].
• Galactose toxicity in the rat as a model for premature ovarian failure: an experimental approach readdressed [2].

High impact information on Ovarian Failure, Premature

• Premature ovarian failure in androgen receptor-deficient mice [3].
• CONTEXT: Evidence suggests that young women with spontaneous premature ovarian failure (sPOF) have significantly lower androgen levels than age-matched regularly menstruating women [4].
• Germ cell deficient (gcd) mouse as a model of premature ovarian failure [5].
• To investigate the presence of mutations and/or polymorphisms in FSHR gene, DNA from 20 POF, 5 of which were diagnosed as resistant ovary syndrome (ROS), and from 44 controls was isolated from peripheral lymphocytes [6].
• Mutation screening and isoform prevalence of the follicle stimulating hormone receptor gene in women with premature ovarian failure, resistant ovary syndrome and polycystic ovary syndrome [7].

Chemical compound and disease context of Ovarian Failure, Premature

• The effect of a luteinizing hormone releasing hormone analogue (HOE 766) was studied in four patients with hypergonadotrophic amenorrhoea (resistant ovary syndrome) [8].
• To elucidate the possible mechanism(s) of vinblastine-induced premature ovarian failure, we studied the effect of vinblastine (VLB) on progesterone (P) and prostaglandin E (PGE) production by rat granulosa cells in vitro [9].

Biological context of Ovarian Failure, Premature

• For the follicle-stimulating hormone (FSH) receptor (FSHR) loss-of-function mutations have been allocated to this region, a homozygous A189V mutation resulting in a resistant ovary syndrome and impaired spermatogenesis and a heterozygous N191I mutation with no apparent phenotype [10].
• Female ENU-treated Apc-mutant and Brca2/Apc double heterozygotes were also susceptible to premature ovarian failure [11].

Gene context of Ovarian Failure, Premature

• Might the "resistant ovary syndrome' come right in the end, with corresponding minor FSH receptor mutations [12]?
• Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency [11].
• Letter: Premature ovarian failure and the "gonadotropin-resistant" ovary syndrome [13].
• Benign thymoma and resistant ovary syndrome [14].

Analytical, diagnostic and therapeutic context of Ovarian Failure, Premature

• CONCLUSIONS: Ovarian follicular activity, previously considered to be rare, as in the "resistant ovary syndrome," is found in the majority of women with POF using pelvic ultrasonography [15].

References