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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Tic Disorders

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Disease relevance of Tic Disorders


Psychiatry related information on Tic Disorders


High impact information on Tic Disorders


Chemical compound and disease context of Tic Disorders

  • There was no evidence that methylphenidate altered the severity of tic disorder, but it may have a weak effect on the frequency of motor (increase) and vocal (decrease) tics [15].
  • METHOD: Subjects from a specialty tic disorders clinic were randomly assigned to receive 8 weeks of treatment with guanfacine or placebo under double-blind conditions [12].
  • Data from ten cases of children and adolescents with tic disorders treated with lithium are presented [16].
  • CONCLUSION: Possible biological and psychosocial determinants of pathological hoarding include association with schizophrenia, OCD, and tic disorders, as well as a possible link through the neurotransmitter dopamine [17].
  • The addition of low-dose haloperidol and pimozide to ongoing SUI treatment has been shown to be effective in up to 65% of SUI-refractory OCD patients, particularly in those with comorbid chronic tic disorder [18].

Gene context of Tic Disorders

  • CONCLUSIONS: Sensory tics seem to be a common and distinctive feature of GTS and that subpopulation of patients with OCD predisposed to tic disorders [8].
  • CONCLUSIONS: Adult onset tic disorders represent an underrecognised condition that is more common than generally appreciated or reported [19].
  • Adult onset tic disorders [19].
  • Basal prolactin levels were influenced by a history of chronic tic disorder and by the duration and severity of obsessive-compulsive symptoms [20].
  • This is the first report of tic disorder occurring as a manifestation of MS [21].

Analytical, diagnostic and therapeutic context of Tic Disorders


  1. Early administration of tiapride to young rats without long-lasting changes in the development of the dopaminergic system. Bock, N., Moll, G.H., Wicker, M., Pilz, J., Rüther, E., Banaschewski, T., Huether, G., Rothenberger, A. Pharmacopsychiatry (2004) [Pubmed]
  2. Overuse of EEG in the evaluation of common neurologic conditions. Matoth, I., Taustein, I., Kay, B.S., Shapira, Y.A. Pediatric neurology. (2002) [Pubmed]
  3. Brief report: effects of propranolol in Tourette syndrome. Sverd, J., Cohen, S., Camp, J.A. Journal of autism and developmental disorders. (1983) [Pubmed]
  4. Carbidopa-levodopa-induced recrudescence of premorbid tic disorder in remission. Latif, T., Leo, R.J., Bakhai, Y.D. Primary care companion to the Journal of clinical psychiatry. (2005) [Pubmed]
  5. Semiology, nosology and criteria for tic disorders. Shapiro, E., Shapiro, A.K. Rev. Neurol. (Paris) (1986) [Pubmed]
  6. Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in patients with and without tics. McDougle, C.J., Goodman, W.K., Leckman, J.F., Lee, N.C., Heninger, G.R., Price, L.H. Arch. Gen. Psychiatry (1994) [Pubmed]
  7. The 4-year course of tic disorders in boys with attention-deficit/hyperactivity disorder. Spencer, T., Biederman, M., Coffey, B., Geller, D., Wilens, T., Faraone, S. Arch. Gen. Psychiatry (1999) [Pubmed]
  8. A controlled study of sensory tics in Gilles de 1a Tourette syndrome and obsessive-compulsive disorder using a structured interview. Chee, K.Y., Sachdev, P. J. Neurol. Neurosurg. Psychiatr. (1997) [Pubmed]
  9. Associated psychopathology in children with both ADHD and chronic tic disorder. Nolan, E.E., Sverd, J., Gadow, K.D., Sprafkin, J., Ezor, S.N. Journal of the American Academy of Child and Adolescent Psychiatry. (1996) [Pubmed]
  10. A double-blind comparison of desipramine and placebo in children and adolescents with chronic tic disorder and comorbid attention-deficit/hyperactivity disorder. Spencer, T., Biederman, J., Coffey, B., Geller, D., Crawford, M., Bearman, S.K., Tarazi, R., Faraone, S.V. Arch. Gen. Psychiatry (2002) [Pubmed]
  11. Long-term methylphenidate therapy in children with comorbid attention-deficit hyperactivity disorder and chronic multiple tic disorder. Gadow, K.D., Sverd, J., Sprafkin, J., Nolan, E.E., Grossman, S. Arch. Gen. Psychiatry (1999) [Pubmed]
  12. A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Scahill, L., Chappell, P.B., Kim, Y.S., Schultz, R.T., Katsovich, L., Shepherd, E., Arnsten, A.F., Cohen, D.J., Leckman, J.F. The American journal of psychiatry. (2001) [Pubmed]
  13. The familial phenotype of obsessive-compulsive disorder in relation to tic disorders: the Hopkins OCD family study. Grados, M.A., Riddle, M.A., Samuels, J.F., Liang, K.Y., Hoehn-Saric, R., Bienvenu, O.J., Walkup, J.T., Song, D., Nestadt, G. Biol. Psychiatry (2001) [Pubmed]
  14. Whole blood serotonin in juvenile obsessive-compulsive disorder. Hanna, G.L., Yuwiler, A., Cantwell, D.P. Biol. Psychiatry (1991) [Pubmed]
  15. Efficacy of methylphenidate for attention-deficit hyperactivity disorder in children with tic disorder. Gadow, K.D., Sverd, J., Sprafkin, J., Nolan, E.E., Ezor, S.N. Arch. Gen. Psychiatry (1995) [Pubmed]
  16. Differential responsiveness to lithium in patients with Tourette disorder. Kerbeshian, J., Burd, L. Neuroscience and biobehavioral reviews. (1988) [Pubmed]
  17. Hoarding: a symptom, not a syndrome. Damecour, C.L., Charron, M. The Journal of clinical psychiatry. (1998) [Pubmed]
  18. Risperidone addition in fluvoxamine-refractory obsessive-compulsive disorder: three cases. McDougle, C.J., Fleischmann, R.L., Epperson, C.N., Wasylink, S., Leckman, J.F., Price, L.H. The Journal of clinical psychiatry. (1995) [Pubmed]
  19. Adult onset tic disorders. Chouinard, S., Ford, B. J. Neurol. Neurosurg. Psychiatr. (2000) [Pubmed]
  20. Prolactin in childhood obsessive-compulsive disorder: clinical correlates and response to clomipramine. Hanna, G.L., McCracken, J.T., Cantwell, D.P. Journal of the American Academy of Child and Adolescent Psychiatry. (1991) [Pubmed]
  21. Simple phonic tic in multiple sclerosis. Lana-Peixoto, M.A., Teixeira, A.L. Mult. Scler. (2002) [Pubmed]
  22. Effectiveness and safety of risperidone for children and adolescents with chronic tic or tourette disorders in Korea. Kim, B.N., Lee, C.B., Hwang, J.W., Shin, M.S., Cho, S.C. Journal of child and adolescent psychopharmacology. (2005) [Pubmed]
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