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MeSH Review:

Persistent Fetal Circulation Syndrome

Larsson, L.E. et al., Gotteiner, N.L. et al., Bartlett, R.H. et al., Filtenborg, J.A., Hendricks-Muñoz, K.D. et al., et al.

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Disease relevance of Persistent Fetal Circulation Syndrome

Best survival results were in persistent fetal circulation (10, 10 survived), followed by congenital diaphragmatic hernia (9, 7 survived), meconium aspiration (44, 37 survived), respiratory distress syndrome (26, 13 survived), and sepsis (8, 3 survived) [1].
The differential responses of dopamine and epinephrine on pulmonary and mesenteric circulations may be significant in the pathophysiology and management of persistent fetal circulation and necrotizing enterocolitis [2].
Eighteen newborn infants with severe hypoxia during the course of idiopathic respiratory distress syndrome, pneumonia, persistent fetal circulation or right diaphragmatic hernia were treated with chlorpromazine with the aim of improving arterial oxygenation by a postulated vasodilatory action on the pulmonary circulation [3].

High impact information on Persistent Fetal Circulation Syndrome

Use of prostacyclin in persistent fetal circulation [4].
We investigated the effects of a continuous infusion of adenosine on oxygenation in term infants with persistent pulmonary hypertension of newborn (PPHN) [5].
We concluded from these results that infants with persistent fetal circulation have an extremely high incidence of sensorineural hearing loss and suggest serial formal audiologic evaluations to aid in detection of hearing-impaired infants [6].
Effects of indomethacin on fetal rat lungs: a possible cause of persistent fetal circulation (PFC) [7].
Transcutaneous PO2 monitoring in infants with persistent fetal circulation who are receiving tolazoline therapy [8].

Chemical compound and disease context of Persistent Fetal Circulation Syndrome

Sodium bicarbonate infusion was used earlier in Group 2 as a prophylaxis against persistent fetal circulation (PFC) (p greater than 0.05) [9].
Pentoxifylline treatment of persistent pulmonary hypertension of newborn [10].
The similarity between the present and the four earlier reported cases in regard to the symptoms and the course of illness, raises the question of the connection between lithium intoxication and persistent fetal circulation being more than coincidental [11].
We report a case of congenital diaphragmatic hernia in which aneurysmal dilatation of ductus arteriosus developed after lipo-prostaglandin E1 (PGE1) therapy for persistent fetal circulation [12].
Although epinephrine preserves the SAP/PAP ratio, dopamine shows preferential pulmonary vasoconstriction, which might be detrimental if it also occurs during the management of infants with persistent fetal circulation [13].

Gene context of Persistent Fetal Circulation Syndrome

Primary diagnoses included respiratory distress syndrome (RDS; 23), pneumonia (12), persistent fetal circulation (PFC; 6), diaphragmatic hernia/hypoplastic lungs (4) [14].

Analytical, diagnostic and therapeutic context of Persistent Fetal Circulation Syndrome

High-frequency oscillation for persistent fetal circulation after repair of congenital diaphragmatic hernia [15].
Extracorporeal membrane oxygenation. Successful treatment of persistent fetal circulation following repair of congenital diaphragmatic hernia [16].
Cardiopulmonary physiology was assessed by Doppler echocardiography in neonates undergoing pre-ECMO evaluation for meconium aspiration syndrome, congenital diaphragmatic hernia, persistent fetal circulation, and sepsis, from March 1987 through July 1992 (n = 136) [17].

References

Extracorporeal membrane oxygenation (ECMO) in neonatal respiratory failure. 100 cases. Bartlett, R.H., Gazzaniga, A.B., Toomasian, J., Coran, A.G., Roloff, D., Rucker, R., Corwin, A.G. Ann. Surg. (1986) [Pubmed]
Systemic, pulmonary and mesenteric perfusion and oxygenation effects of dopamine and epinephrine. Cheung, P.Y., Barrington, K.J., Pearson, R.J., Bigam, D.L., Finer, N.N., Van Aerde, J.E. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
The effect of chlorpromazine in severe hypoxia in newborn infants. Larsson, L.E., Ekström-Jodal, B., Hjalmarson, O. Acta paediatrica Scandinavica. (1982) [Pubmed]
Use of prostacyclin in persistent fetal circulation. Lock, J.E., Olley, P.M., Coceani, F., Swyer, P.R., Rowe, R.D. Lancet (1979) [Pubmed]
Adenosine infusion improves oxygenation in term infants with respiratory failure. Konduri, G.G., Garcia, D.C., Kazzi, N.J., Shankaran, S. Pediatrics (1996) [Pubmed]
Hearing loss in infants with persistent fetal circulation. Hendricks-Muñoz, K.D., Walton, J.P. Pediatrics (1988) [Pubmed]
Effects of indomethacin on fetal rat lungs: a possible cause of persistent fetal circulation (PFC). Harker, L.C., Kirkpatrick, S.E., Friedman, W.F., Bloor, C.M. Pediatr. Res. (1981) [Pubmed]
Transcutaneous PO2 monitoring in infants with persistent fetal circulation who are receiving tolazoline therapy. Boyle, R.J., Oh, W. Pediatrics (1978) [Pubmed]
Improving survival in the treatment of congenital diaphragmatic hernia. Sawyer, S.F., Falterman, K.W., Goldsmith, J.P., Arensman, R.M. Ann. Thorac. Surg. (1986) [Pubmed]
Pentoxifylline treatment of persistent pulmonary hypertension of newborn. Lauterbach, R. Eur. J. Pediatr. (1993) [Pubmed]
Persistent pulmonary hypertension after lithium intoxication in the newborn. Filtenborg, J.A. Eur. J. Pediatr. (1982) [Pubmed]
Aneurysmal dilatation of ductus arteriosus during lipo-prostaglandin E1 therapy for diaphragmatic hernia. Tohyama, M., Baba, A., Tsuno, T., Aonuma, K., Komiyama, A. Eur. J. Pediatr. (1993) [Pubmed]
The effects of dopamine and epinephrine on hemodynamics and oxygen metabolism in hypoxic anesthetized piglets. Cheung, P.Y., Barrington, K.J. Critical care (London, England) (2001) [Pubmed]
High-frequency oscillatory ventilation combined with intermittent mandatory ventilation in critically ill neonates: 3 years of experience. Blum-Hoffmann, E., Kopotic, R.J., Mannino, F.L. Eur. J. Pediatr. (1988) [Pubmed]
High-frequency oscillation for persistent fetal circulation after repair of congenital diaphragmatic hernia. Fujino, Y., Takezawa, J., Nishimura, M., Imanaka, H., Taenaka, N., Yoshiya, I. Crit. Care Med. (1989) [Pubmed]
Extracorporeal membrane oxygenation. Successful treatment of persistent fetal circulation following repair of congenital diaphragmatic hernia. Hardesty, R.L., Griffith, B.P., Debski, R.F., Jeffries, M.R., Borovetz, H.S. J. Thorac. Cardiovasc. Surg. (1981) [Pubmed]
Echocardiographic prediction of neonatal ECMO outcome. Gotteiner, N.L., Harper, W.R., Gidding, S.S., Berdusis, K., Wiley, A.M., Reynolds, M., Benson, D.W. Pediatric cardiology. (1997) [Pubmed]

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