The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Extracorporeal Membrane Oxygenation

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Extracorporeal Membrane Oxygenation


High impact information on Extracorporeal Membrane Oxygenation


Chemical compound and disease context of Extracorporeal Membrane Oxygenation


Biological context of Extracorporeal Membrane Oxygenation


Anatomical context of Extracorporeal Membrane Oxygenation


Associations of Extracorporeal Membrane Oxygenation with chemical compounds


Gene context of Extracorporeal Membrane Oxygenation

  • We investigated the expression pattern of NO-generating enzyme nitric-oxide synthase (NOS) (both endothelial [eNOS] and inducible [iNOS] isoforms) in the lungs of CDH patients with PH and evaluated the influence of ECMO on the expression levels of these genes in an attempt to understand the underlying molecular mechanisms [30].
  • CONCLUSIONS: These data suggest that the infants who survive ECMO resolve their pulmonary inflammation and that in non-survivors the ratio of TNF-alpha against its receptor antagonists is increased and is associated with a poor outcome [31].
  • Concentrations of circulating neutrophil elastase increase significantly during ECMO [32].
  • Plasma from the ECMO experiments did not induce ICAM-1 expression of cultured HUVEC [33].
  • MMP-2 may play a role in the development of platelet dysfunction caused by ECMO [34].

Analytical, diagnostic and therapeutic context of Extracorporeal Membrane Oxygenation

  • The data from this report support the concept that infants undergoing surgical repair of diaphragmatic hernia, when ECMO is not available, should be referred to an ECMO center in the early postoperative period [35].
  • Furthermore infants with prenatal diagnosis of diaphragmatic hernia should be delivered at a center where surgical as well as ECMO expertise are available [35].
  • Concomitant procedures were frequently performed and included repair of an intra-atrial baffle leak (prior Mustard procedure), closure of an atrial septal defect, repair of partial anomalous pulmonary venous return, reconstruction of the pulmonary venous confluence, ECMO decannulation, and splenectomy [36].
  • Fourteen did not receive allopurinol, whereas 11 were treated with 10 mg/kg after meeting criteria and before cannulation, in addition to a 20-mg/kg priming dose to the ECMO circuit [37].
  • This amount of DEHP extrapolates in the ECMO patient to a potential exposure of 20 to 70 times that exposure from other medical devices or procedures, such as transfusions, dialysis, or short-term cardiopulmonary bypass [13].


  1. Use of liquid ventilation with perflubron during extracorporeal membrane oxygenation: chest radiographic appearances. Gross, G.W., Greenspan, J.S., Fox, W.W., Rubenstein, S.D., Wolfson, M.R., Shaffer, T.H. Radiology. (1995) [Pubmed]
  2. Pharmacokinetic changes during extracorporeal membrane oxygenation: implications for drug therapy of neonates. Buck, M.L. Clinical pharmacokinetics. (2003) [Pubmed]
  3. Vancomycin: pharmacokinetics and administration regimens in neonates. de Hoog, M., Mouton, J.W., van den Anker, J.N. Clinical pharmacokinetics. (2004) [Pubmed]
  4. Procedural variables which affect activated clotting time test results during extracorporeal membrane oxygenation therapy. Uden, D.L., Payne, N.R., Kriesmer, P., Cipolle, R.J. Crit. Care Med. (1989) [Pubmed]
  5. Plasma lactate concentration as a predictor of death in neonates with severe hypoxemia requiring extracorporeal membrane oxygenation. Cheung, P.Y., Finer, N.N. J. Pediatr. (1994) [Pubmed]
  6. Exposure to di(2-ethylhexyl)phthalate in infants receiving extracorporeal membrane oxygenation. Shneider, B., Schena, J., Truog, R., Jacobson, M., Kevy, S. N. Engl. J. Med. (1989) [Pubmed]
  7. Protection of platelets during long-term extracorporeal membrane oxygenation in sheep with a single dose of a disintegrin. Shigeta, O., Gluszko, P., Downing, S.W., Lu, W., Niewiarowski, S., Edmunds, L.H. Circulation (1992) [Pubmed]
  8. Pulmonary morphology in a multihospital collaborative extracorporeal membrane oxygenation project. I. Light microscopy. Pratt, P.C., Vollmer, R.T., Shelburne, J.D., Crapo, J.D. Am. J. Pathol. (1979) [Pubmed]
  9. Congenital diaphragmatic hernia. Stabilization and repair on ECMO. Lally, K.P., Paranka, M.S., Roden, J., Georgeson, K.E., Wilson, J.M., Lillehei, C.W., Breaux, C.W., Poon, M., Clark, R.H., Atkinson, J.B. Ann. Surg. (1992) [Pubmed]
  10. Favourable clinical outcome in patients with cardiogenic shock due to fulminant myocarditis supported by percutaneous extracorporeal membrane oxygenation. Asaumi, Y., Yasuda, S., Morii, I., Kakuchi, H., Otsuka, Y., Kawamura, A., Sasako, Y., Nakatani, T., Nonogi, H., Miyazaki, S. Eur. Heart J. (2005) [Pubmed]
  11. Changes in the pharmacodynamic response to fentanyl in neonates during continuous infusion. Arnold, J.H., Truog, R.D., Scavone, J.M., Fenton, T. J. Pediatr. (1991) [Pubmed]
  12. Cerebral oxygenation and hemodynamics during induction of extracorporeal membrane oxygenation as investigated by near infrared spectrophotometry. Liem, K.D., Hopman, J.C., Oeseburg, B., de Haan, A.F., Festen, C., Kollée, L.A. Pediatrics (1995) [Pubmed]
  13. Extracorporeal membrane oxygenation exposes infants to the plasticizer, di(2-ethylhexyl)phthalate. Karle, V.A., Short, B.L., Martin, G.R., Bulas, D.I., Getson, P.R., Luban, N.L., O'Brien, A.M., Rubin, R.J. Crit. Care Med. (1997) [Pubmed]
  14. Dexamethasone therapy in neonates treated with extracorporeal membrane oxygenation. Griffin, M.P., Wooldridge, P., Alford, B.A., McIlhenny, J., Ksenich, R.A. J. Pediatr. (2004) [Pubmed]
  15. Urinary nitrite and nitrate concentrations in patients with idiopathic persistent pulmonary hypertension of the newborn and effect of extracorporeal membrane oxygenation. Dollberg, S., Warner, B.W., Myatt, L. Pediatr. Res. (1995) [Pubmed]
  16. Pharmacokinetics and pharmacodynamics of bumetanide in neonates treated with extracorporeal membrane oxygenation. Wells, T.G., Fasules, J.W., Taylor, B.J., Kearns, G.L. J. Pediatr. (1992) [Pubmed]
  17. In vitro evaluation of a new lithium dilution method of measuring cardiac output and shunt fraction in patients undergoing venovenous extracorporeal membrane oxygenation. Linton, R., Turtle, M., Band, D., O'Brien, T., Jonas, M. Crit. Care Med. (1998) [Pubmed]
  18. Physiology and regulation. Ionized calcium, magnesium and lactate measurements in critical care settings. Toffaletti, J. Am. J. Clin. Pathol. (1995) [Pubmed]
  19. Effect of extracorporeal membrane oxygenation on platelets in newborns. Robinson, T.M., Kickler, T.S., Walker, L.K., Ness, P., Bell, W. Crit. Care Med. (1993) [Pubmed]
  20. Coadministration of theophylline enhances diuretic response to furosemide in infants during extracorporeal membrane oxygenation: a randomized controlled pilot study. Lochan, S.R., Adeniyi-Jones, S., Assadi, F.K., Frey, B.M., Marcus, S., Baumgart, S. J. Pediatr. (1998) [Pubmed]
  21. Five-year follow-up of neonates with reconstructed right common carotid arteries after extracorporeal membrane oxygenation. Desai, S.A., Stanley, C., Gringlas, M., Merton, D.A., Wolfson, P.J., Needleman, L., Graziani, L.J., Baumgart, S. J. Pediatr. (1999) [Pubmed]
  22. Nucleated erythrocyte count in newborn infants with left-sided congenital diaphragmatic hernia: relationship with the need for extracorporeal membrane oxygenation and survival. Green, D.W., Lyon, J., Ackerman, N.B., Mimouni, F. J. Pediatr. (1995) [Pubmed]
  23. Plasma thromboxane and pulmonary artery pressure in neonates treated with extracorporeal membrane oxygenation. Bui, K.C., Martin, G., Kammerman, L.A., Hammerman, C., Hill, V., Short, B.L. J. Thorac. Cardiovasc. Surg. (1992) [Pubmed]
  24. Congenital diaphragmatic hernia without herniation of the liver: does the lung-to-head ratio predict survival? Sbragia, L., Paek, B.W., Filly, R.A., Harrison, M.R., Farrell, J.A., Farmer, D.L., Albanese, C.T. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. (2000) [Pubmed]
  25. The use of alteplase in a newborn receiving extracorporeal membrane oxygenation. Glover, M.L., Camacho, M.T., Wolfsdorf, J. The Annals of pharmacotherapy. (1999) [Pubmed]
  26. Detrimental effects of standard medical therapy in congenital diaphragmatic hernia. Kays, D.W., Langham, M.R., Ledbetter, D.J., Talbert, J.L. Ann. Surg. (1999) [Pubmed]
  27. Inactivation of heparin during extracorporeal circulation in infants. Green, T.P., Isham-Schopf, B., Irmiter, R.J., Smith, C., Uden, D.L., Steinhorn, R.H. Clin. Pharmacol. Ther. (1990) [Pubmed]
  28. Pharmacokinetics of gentamicin in neonates on extracorporeal membrane oxygenation. Southgate, W.M., DiPiro, J.T., Robertson, A.F. Antimicrob. Agents Chemother. (1989) [Pubmed]
  29. Neonates with congenital diaphragmatic hernia: radiographic findings during partial liquid ventilation. Garver, K.A., Kazerooni, E.A., Hirschl, R.B., DiPietro, M.A. Radiology. (1996) [Pubmed]
  30. Pulmonary hypertension in human newborns with congenital diaphragmatic hernia is associated with decreased vascular expression of nitric-oxide synthase. Shehata, S.M., Sharma, H.S., Mooi, W.J., Tibboel, D. Cell Biochem. Biophys. (2006) [Pubmed]
  31. Cytokine imbalance in infants receiving extracorporeal membrane oxygenation for respiratory failure. Mildner, R.J., Taub, N., Vyas, J.R., Killer, H.M., Firmin, R.K., Field, D.J., Kotecha, S. Biol. Neonate (2005) [Pubmed]
  32. Neutrophil and cytokine activation with neonatal extracorporeal membrane oxygenation. Fortenberry, J.D., Bhardwaj, V., Niemer, P., Cornish, J.D., Wright, J.A., Bland, L. J. Pediatr. (1996) [Pubmed]
  33. Leukocyte and endothelial activation in a laboratory model of extracorporeal membrane oxygenation (ECMO). Graulich, J., Walzog, B., Marcinkowski, M., Bauer, K., Kössel, H., Fuhrmann, G., Bührer, C., Gaehtgens, P., Versmold, H.T. Pediatr. Res. (2000) [Pubmed]
  34. The mechanisms of platelet dysfunction during extracorporeal membrane oxygenation in critically ill neonates. Cheung, P.Y., Sawicki, G., Salas, E., Etches, P.C., Schulz, R., Radomski, M.W. Crit. Care Med. (2000) [Pubmed]
  35. Recent experience with diaphragmatic hernia and ECMO. Howell, C.G., Hatley, R.M., Boedy, R.F., Rogers, D.M., Kanto, W.P., Parrish, R.A. Ann. Surg. (1990) [Pubmed]
  36. Pediatric lung transplantation--are there surgical contraindications? Koutlas, T.C., Bridges, N.D., Gaynor, J.W., Nicolson, S.C., Steven, J.M., Spray, T.L. Transplantation (1997) [Pubmed]
  37. Purine metabolism and inhibition of xanthine oxidase in severely hypoxic neonates going onto extracorporeal membrane oxygenation. Marro, P.J., Baumgart, S., Delivoria-Papadopoulos, M., Zirin, S., Corcoran, L., McGaurn, S.P., Davis, L.E., Clancy, R.R. Pediatr. Res. (1997) [Pubmed]
WikiGenes - Universities