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Chemical Compound Review

Divascol     2-benzyl-4,5-dihydro-1H- imidazole

Synonyms: Benzolin, Imidalin, Prefaxil, Pridazole, Priscol, ...
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Disease relevance of Priscoline


Psychiatry related information on Priscoline

  • In contrast, inhibition of the colonic phasic and tonic motor activity by alpha 2-adrenoceptor stimulation was reversed competitively by tolazoline [5].

High impact information on Priscoline


Chemical compound and disease context of Priscoline


Biological context of Priscoline

  • The density of "specific" [3H]idazoxan binding sites (defined by 100 microM tolazoline) was twice as high as that of [3H]rauwolscine in rat kidney and four times as high as that of [3H]yohimbine in human kidney [14].
  • Production of pulmonary vasodilation by tolazoline, independent of nitric oxide production in neonatal lambs [11].
  • It is possible that changes associated with the elevated heart rate (e.g., less cardiac filling) in tolazoline-treated animals resulted in greater susceptibility to microwave-induced heating and the lower survival time [15].
  • The effects of tolazoline on the distribution of cardiac output in normoxemic and hypoxemic lambs [16].
  • The average neonatal pharmacokinetics predict that each 1 mg of tolazoline HCl per kilogram pulse dose will increase the plasma concentration of tolazoline base by 0.5 mg/L [17].

Anatomical context of Priscoline


Associations of Priscoline with other chemical compounds


Gene context of Priscoline


Analytical, diagnostic and therapeutic context of Priscoline


  1. Tolazoline and acute renal failure in the newborn. Trompeter, R.S., Chantler, C., Haycock, G.B. Lancet (1981) [Pubmed]
  2. Diagnosis and management of postoperative pulmonary hypertensive crisis. Wheller, J., George, B.L., Mulder, D.G., Jarmakani, J.M. Circulation (1979) [Pubmed]
  3. Use of ATP-MgCl2 in the evaluation and treatment of children with pulmonary hypertension secondary to congenital heart defects. Brook, M.M., Fineman, J.R., Bolinger, A.M., Wong, A.F., Heymann, M.A., Soifer, S.J. Circulation (1994) [Pubmed]
  4. Congenital diaphragmatic hernia. New concept in management. Shochat, S.J., Naeye, R.L., Ford, W.D., Whitman, V., Maisels, M.J. Ann. Surg. (1979) [Pubmed]
  5. Colonic alpha 2-adrenoceptor-mediated responses in the pony. Roger, T., Ruckebusch, Y. J. Vet. Pharmacol. Ther. (1987) [Pubmed]
  6. Vasodilators and prostaglandin inhibitors in primary pulmonary hypertension. Hermiller, J.B., Bambach, D., Thompson, M.J., Huss, P., Fontana, M.E., Magorien, R.D., Unverferth, D.V., Leier, C.V. Ann. Intern. Med. (1982) [Pubmed]
  7. The use of tolazoline hydrochloride as a pulmonary vasodilator in potentially fatal episodes of pulmonary vasoconstriction after cardiac surgery in children. Jones, O.D., Shore, D.F., Rigby, M.L., Leijala, M., Scallan, J., Shinebourne, E.A., Lincoln, J.C. Circulation (1981) [Pubmed]
  8. Morphological, cytochemical and neuropharmacological evidence for the presence of catecholamines in hydrozoan planulae. Kolberg, K.J., Martin, V.J. Development (1988) [Pubmed]
  9. The independent effects of hyperventilation, tolazoline, and dopamine on infants with persistent pulmonary hypertension. Drummond, W.H., Gregory, G.A., Heymann, M.A., Phibbs, R.A. J. Pediatr. (1981) [Pubmed]
  10. Hypochloremic metabolic alkalosis following tolazoline-induced gastric hypersecretion. Adams, J.M., Hyde, W.H., Procianoy, R.S., Rudolph, A.J. Pediatrics (1980) [Pubmed]
  11. Production of pulmonary vasodilation by tolazoline, independent of nitric oxide production in neonatal lambs. Curtis, J., Palacino, J.J., O'Neill, J.T. J. Pediatr. (1996) [Pubmed]
  12. Pulsed Doppler flow characteristics of ductus arteriosus in infants with associated congenital anomalies of the heart or great arteries. Cloez, J.L., Isaaz, K., Pernot, C. Am. J. Cardiol. (1986) [Pubmed]
  13. The effect of intracerebroventricular administration of catecholamines and their antagonists on rectal temperature of Mastomys natalensis. Shukla, R., Srimal, R.C., Dhawan, B.N. Naunyn Schmiedebergs Arch. Pharmacol. (1981) [Pubmed]
  14. [3H]idazoxan and some other alpha 2-adrenergic drugs also bind with high affinity to a nonadrenergic site. Michel, M.C., Brodde, O.E., Schnepel, B., Behrendt, J., Tschada, R., Motulsky, H.J., Insel, P.A. Mol. Pharmacol. (1989) [Pubmed]
  15. Tolazoline decreases survival time during microwave-induced lethal heat stress in anesthetized rats. Jauchem, J.R., Chang, K.S., Frei, M.R. Proc. Soc. Exp. Biol. Med. (1996) [Pubmed]
  16. The effects of tolazoline on the distribution of cardiac output in normoxemic and hypoxemic lambs. Gregory, G.A., Lister, G., Heymann, M.A. Pediatr. Res. (1984) [Pubmed]
  17. Oliguria and tolazoline pharmacokinetics in the newborn. Ward, R.M., Daniel, C.H., Kendig, J.W., Wood, M.A. Pediatrics (1986) [Pubmed]
  18. Active transport of nicotine by the isolated choroid plexus in vitro. Spector, R., Goldberg, M.J. J. Neurochem. (1982) [Pubmed]
  19. Comparison of the effects of histamine and tolazoline on adenylate cyclase activity from guinea pig heart. Weinryb, I., Michel, I.M. J. Med. Chem. (1975) [Pubmed]
  20. Effect of tolazoline on persistent hypoxemia in neonatal respiratory distress. Purohit, D.M., Pai, S., Levkoff, A.H. Crit. Care Med. (1978) [Pubmed]
  21. Meconium aspiration and tolazoline. Duc, G. Pediatrics (1978) [Pubmed]
  22. Small vessel leg angiography for distal vessel bypass grafts. Kozak, B.E., Bedell, J.E., Rosch, J. J. Vasc. Surg. (1988) [Pubmed]
  23. Structure-activity relationships of clonidine- and tolazoline-like compounds at histamine and alpha-adrenoceptor sites. Malta, E., Ong, J.S., Raper, C., Tawa, P.E., Vaughan, G.N. Br. J. Pharmacol. (1980) [Pubmed]
  24. Effects of tolazoline and prostacyclin on pulmonary hypertension in infants after cardiac surgery. Schranz, D., Zepp, F., Iversen, S., Wippermann, C., Huth, R., Zimmer, B., Jüngst, B.K., Oelert, H. Crit. Care Med. (1992) [Pubmed]
  25. Adrenergic receptors on smooth muscle cells isolated from human penile corpus cavernosum. Costa, P., Soulie-Vassal, M.L., Sarrazin, B., Rebillard, X., Navratil, H., Bali, J.P. J. Urol. (1993) [Pubmed]
  26. Tolazoline therapy for persistent pulmonary hypertension after congenital diaphragmatic hernia repair. Bloss, R.S., Turmen, T., Beardmore, H.E., Aranda, J.V. J. Pediatr. (1980) [Pubmed]
  27. Nonlocalized lower gastrointestinal bleeding: provocative bleeding studies with intraarterial tPA, heparin, and tolazoline. Ryan, J.M., Key, S.M., Dumbleton, S.A., Smith, T.P. Journal of vascular and interventional radiology : JVIR. (2001) [Pubmed]
  28. Histamine 2 receptor-mediated immunomodulation in the mouse. I. Immunomodulation by the H2 agonist tolazoline. Van Dijk, H., Rapis, M., Jacobse-Geels, H.E., Willers, J.M. Clin. Exp. Immunol. (1979) [Pubmed]
  29. Blood pressure following microinjection of somatostatin related peptides into the rat nucleus tractus solitarii. Koda, L.Y., Ling, N., Benoit, R., Madamba, S.G., Bakhit, C. Eur. J. Pharmacol. (1985) [Pubmed]
  30. Effect of glucagon and some other alpha and beta adrenergic agonists and antagonists on alanine amino transferase of perfused rat liver. Begum, N.A., Datta, A.G. Mol. Cell. Biochem. (1991) [Pubmed]
  31. Tolazoline-augmented arteriography in the evaluation of bone and soft-tissue tumors. Kadir, S., Athanasoulis, C.A., Waltman, A.C. Radiology. (1979) [Pubmed]
  32. Echocardiography in hypoxemic neonatal pulmonary disease. Johnson, G.L., Cunningham, M.D., Desai, N.S., Cottrill, C.M., Noonan, J.A. J. Pediatr. (1980) [Pubmed]
  33. Bilateral upper extremity ischemia after administration of dihydroergotamine-heparin for prophylaxis of deep venous thrombosis. Seifert, K.B., Blackshear, W.M., Cruse, C.W., Schwartz, J.A., Suslavitch, F. J. Vasc. Surg. (1988) [Pubmed]
  34. Differences between presynaptic and postsynaptic alpha-adrenoceptors in the isolated nictitating membrane of the cat: effects of metanephrine and tolazoline. Arbilla, S., Langer, S.Z. Br. J. Pharmacol. (1978) [Pubmed]
  35. Hemodynamic consequences of tolazoline in neonatal group B streptococcal bacteremia: an animal model. Meadow, W.L., Meus, P.J. Pediatr. Res. (1984) [Pubmed]
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