Disease relevance of High-Frequency Ventilation

• Heliox improves gas exchange during high-frequency ventilation in a pediatric model of acute lung injury [1].
• Comparison of venous admixture during high-frequency ventilation and conventional ventilation in oleic acid-induced pulmonary edema in dogs [2].
• We studied the effect of external high-frequency oscillation using an oscillator (Hayek oscillator [HO]) on 20 patients with severe chronic obstructive pulmonary disease (COPD) [3].
• For this reason high-frequency ventilation was instituted in all patients in order to improve CO2 elimination and induce respiratory alkalosis [4].
• In order to study the effect of high frequency ventilation on the pulmonary gas exchange in respiratory failure, we measured the PaO2 and other pulmonary gas exchange parameters for ventilatory rates of 0.5, 1.2, 4.8, and 16 Hz in dogs, to which acute respiratory failure was created by intravenous infusion of oleic acid [5].

High impact information on High-Frequency Ventilation

• Furthermore, we show that the digital flexor muscles have minimal ability to contribute to or regulate significantly the 2.5-Hz cycle of movement, but are ideally arranged to damp these high-frequency oscillations in the limb [6].
• We systematically studied the effect on pulmonary CO2 elimination (VCO2) of varying f (2-30 Hz) and VT (1-7 ml/kg) as well as lung volume (VL) in 13 anesthetized, paralyzed dogs in order to examine the contribution of those variables that are thought to be important in determining gas exchange by high frequency ventilation [7].
• High-frequency oscillations and seizure generation in neocortical epilepsy [8].
• TN-R-/- mice expressed normal high-frequency oscillations (ripples) in CA1 and only a slight reduction of peak theta frequency [9].
• Both the gamma frequency and high frequency oscillations were attenuated by the gap junction blocker carbenoxolone [10].

Chemical compound and disease context of High-Frequency Ventilation

• Nitric oxide therapy used with high frequency ventilation has improved the outcome of babies with severe MAS and pulmonary hypertension [11].

Biological context of High-Frequency Ventilation

• Effect of high-frequency positive-pressure ventilation on halothane ablation of hypoxic pulmonary vasoconstriction [12].
• The effects of changing tidal volume (VT) and frequency (f) on the distribution of ventilation during high-frequency ventilation (HFV) were assessed from the washout of nitrogen-13 by positron emission tomography [13].
• The high-frequency oscillations of systolic blood pressure were increased by losartan in the two series of hypertensive rats [14].
• We measured the rate of CO2 elimination (VCO2) by oscillatory high frequency ventilation (HFV) in 8 normal subjects and studied the effects of varying frequency, stroke volume, lung volume, and bronchodilation on VCO2 [15].
• DATA SYNTHESIS: After an overview of the potential benefits and technical aspects of helium-oxygen gas mixtures, the role of heliox is addressed for asthma, aerosolized medication delivery, upper airway obstruction, postextubation stridor, croup, bronchiolitis, and high-frequency ventilation [16].

Anatomical context of High-Frequency Ventilation

• We show that because of its voltage dependence, NMDA receptor activation acts to amplify the effect on the soma of the high-frequency oscillation of the dendrites, which is normally too weak to exert a large influence on the overall oscillation frequency of the neuron [17].
• PURPOSE: Fast ripples (FRs) are interictal, pathological, high-frequency oscillations in the 200- to 600-Hz range, which can be recorded from limbic regions capable of generating spontaneous seizures in rodent models of epilepsy and in human mesial temporal lobe epilepsy [18].
• We conclude that high-frequency oscillations in differential air-sac pressure enhance access to and utilization of the O(2) stores in the air sacs during a dive [19].
• OBJECTIVE: Since high frequency oscillations (HFOs) evoked by upper limb stimulation are susceptible to arousal fluctuation, we verified whether administration of modafinil, a vigilance promoting drug, modifies such responses at different levels of the somatosensory system [20].
• Distinct, very high frequency oscillations in the activity and amount of active isozyme of lactate dehydrogenase in murine erythroleukaemic cells and a cell-free system [21].

Associations of High-Frequency Ventilation with chemical compounds

• In the case of high frequency oscillation, the time lag to start the oscillation, the initial amplitude, and the initial frequency were not affected by vanadate, though the oscillation once started was damped more quickly at higher concentrations of vanadate [22].
• Ventilatory requirements using high-frequency oscillation (HFO) during simulated altitude exposure were investigated in control dogs and animals with oleic acid-induced lung injury [23].
• Effect of high-frequency ventilation on histamine-induced lung injury in dogs [24].
• Effect of air and heliox as carrier gas on CO2 transport in a model of high-frequency oscillation comparing two oscillators [25].
• Half of both groups were subsequently ventilated for 3 h with 100% O2 by conventional mechanical ventilation (CMV) and half by high frequency oscillation superimposed onto backup mechanical ventilation (HFOV) [26].

Gene context of High-Frequency Ventilation

• The olfactory bulb responses to odours display evident temporal organization, both in the form of high-frequency oscillations and precisely replicating triplets of spikes [27].
• High-frequency oscillations in circulating amylin concentrations in healthy humans [28].
• Pulmonary function in preterm infants whose lungs were ventilated conventionally or by high-frequency oscillation [29].
• The benefits of both partial and total techniques have been demonstrated in animal models of neonatal and adult respiratory distress syndrome, aspiration syndromes and congenital diaphragmatic hernia and also in combination with other therapeutic modalities including extracorporeal membrane oxygenation, high-frequency ventilation and nitric oxide [30].
• After a preparative phase they were randomly assigned either first to conventional mechanical ventilation (CMV; delivered by a Siemens Servo 900 C), followed by high-frequency ventilation (HFV; delivered by Percussionaire VDR 1 at 10 Hz) or vice versa, each period lasting 4 h [31].

Analytical, diagnostic and therapeutic context of High-Frequency Ventilation

• The effects of high frequency ventilation in combination with sustained inflations was studied in the surfactant-deficient lungs of 18 New Zealand White rabbits (weight 1.9-2.1 kg) during anaesthesia with urethane and neuromuscular block with pancuronium [32].
• Combined high frequency ventilation (CHFV) with 8 mmHg (1.0 kPa) continuous positive airway pressure (CPAP) and without CPAP (CHFV0) were compared to each other, and to continuous positive pressure ventilation (CPPV) with 8 mmHg (1.0 kPa) CPAP in pigs with oleic acid induced lung injury [33].
• These include: anti-inflammatory drugs, medications to counter the effect of prostaglandin-related compounds, high-frequency ventilation, exogenous surfactant, inhaled nitric oxide and liquid ventilation [34].
• To determine the effect of constriction of small airways on gas exchange during such high-frequency ventilation (HFV), we ventilated five anesthetized, paralyzed, and vagotomized dogs via a tracheal cannula before and during intravenous histamine infusion [35].

References