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MeSH Review:

Trophoblastic Tumor, Placental Site

Shih, I.M. et al., Nagelberg, S.B. et al., Shaw, S.W. et al., Swisher, E. et al., Ino, K. et al., et al.

Li, Leung, Cheung, Yu, Chan, Wong, Ordi, Romagosa, Tavassoli, Nogales, Palacin, Condom, Torné, Cardesa, Shih, Kurman,

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Disease relevance of Trophoblastic Tumor, Placental Site

The differences in the Ki-67 labeling index were statistically significant (P < .001) between exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma [1].
HLA-G immunoreactivity was present in all the IT cells of exaggerated placental sites and placental site trophoblastic tumors and in 70-100% of IT cells in placental site nodules and epithelioid trophoblastic tumors [2].
Failure of the placental-site trophoblastic tumor to produce large amounts of estrogen, in contrast to normal pregnancy and hydatidiform mole, resulted in marked androgen/estrogen imbalance, high circulating concentrations of free testosterone, and virilization.(ABSTRACT TRUNCATED AT 250 WORDS)[3]
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report [4].
BACKGROUND: We present the first case using [18F]fluorodeoxyglucose positron emission tomography (PET) for the evaluation of multiple lung nodules in a woman with placental site trophoblastic tumor (PSTT) and history of pulmonary tuberculosis [4].

High impact information on Trophoblastic Tumor, Placental Site

Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor [5].
Characteristic diffuse positivity for melanoma cell adhesion molecule and human leucocyte antigen G was found on immunohistochemical investigation, confirming the diagnosis of placental site trophoblastic tumor [6].
p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations [7].
In this study we investigated the expression and localization of P-LAP and A-LAP in human trophoblastic cells in the normal placenta (n = 26), gestational choriocarcinoma (n = 8), and placental site trophoblastic tumor (n = 3) [8].
CD10 was also positive in the syncytiotrophoblast, cytotrophoblast, and intermediate trophoblast of normal gestations, partial and complete moles, choriocarcinoma, and placental site trophoblastic tumors [9].

Chemical compound and disease context of Trophoblastic Tumor, Placental Site

Formalin-fixed tissue samples from 24 normal implantation sites, 19 exaggerated placental sites, five molar implantation sites, 16 placental site trophoblastic tumors, and 12 choriocarcinomas were stained with a Mel-CAM-specific polyclonal antibody and a Ki-67 antibody using streptavidin-biotin immunoperoxidase with two different chromagens [1].
Direct sampling of the uterine veins at the time of hysterectomy documented testosterone and estradiol production, presumably by the placental-site trophoblastic tumor [3].
OBJECTIVE: We document a case of long-term remission in a patient with metastatic placental site trophoblastic tumor (PSTT) and attempt to determine the response rate of metastatic PSTT to EMA/CO (etoposide, methotrexate, actinomycin-D, cyclophosphamide, and vincristine) combination chemotherapy based on available reports [10].

Anatomical context of Trophoblastic Tumor, Placental Site

In addition, NEP was also expressed on intermediate trophoblasts in placental site trophoblastic tumors [11].

Gene context of Trophoblastic Tumor, Placental Site

P53 gene product and EGF-receptor are highly expressed in placental site trophoblastic tumor [12].
Placental site trophoblastic tumor: human placental lactogen and pregnancy-associated major basic protein as immunohistologic markers [13].
Prominent expression of H19 was found in placental site trophoblastic tumor and gestational choriocarcinoma [14].
Immunostaining on choriocarcinoma and placental site trophoblastic tumor showed reduced expression of maspin in all the tumor cells [15].
Among cases of gestational trophoblastic diseases, c-mos immunoreactivity was found in all hydatidiform moles and choriocarcinomas, but in none of the placental site trophoblastic tumors [16].

References

Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. Shih, I.M., Kurman, R.J. Hum. Pathol. (1998) [Pubmed]
HLA-G immunoreactivity is specific for intermediate trophoblast in gestational trophoblastic disease and can serve as a useful marker in differential diagnosis. Singer, G., Kurman, R.J., McMaster, M.T., Shih, I.e.M. Am. J. Surg. Pathol. (2002) [Pubmed]
Clinical and laboratory investigation of a virilized woman with placental-site trophoblastic tumor. Nagelberg, S.B., Rosen, S.W. Obstetrics and gynecology. (1985) [Pubmed]
Exclusion of lung metastases in placental site trophoblastic tumor using [18F]fluorodeoxyglucose positron emission tomography: a case report. Shaw, S.W., Wang, C.W., Ma, S.Y., Ng, K.K., Chang, T.C. Gynecol. Oncol. (2005) [Pubmed]
Activation of mitogen-activated protein kinase is required for migration and invasion of placental site trophoblastic tumor. Köbel, M., Pohl, G., Schmitt, W.D., Hauptmann, S., Wang, T.L., Shih, I.e.M. Am. J. Pathol. (2005) [Pubmed]
Placental site trophoblastic tumor of the mediastinum. Went, P.T., Dirnhofer, S., Stallmach, T., Taverna, C., Singer, G. Hum. Pathol. (2005) [Pubmed]
p63 expression is useful in the distinction of epithelioid trophoblastic and placental site trophoblastic tumors by profiling trophoblastic subpopulations. Shih, I.M., Kurman, R.J. Am. J. Surg. Pathol. (2004) [Pubmed]
Expression of placental leucine aminopeptidase and adipocyte-derived leucine aminopeptidase in human normal and malignant invasive trophoblastic cells. Ino, K., Kikkawa, F., Suzuki, T., Kajiyama, H., Shibata, K., Nomura, S., Itakura, A., Ito, M., Nagasaka, T., Hattori, A., Tsujimoto, M., Mizutani, S. Lab. Invest. (2003) [Pubmed]
CD10 expression in epithelial tissues and tumors of the gynecologic tract: a useful marker in the diagnosis of mesonephric, trophoblastic, and clear cell tumors. Ordi, J., Romagosa, C., Tavassoli, F.A., Nogales, F., Palacin, A., Condom, E., Torné, A., Cardesa, A. Am. J. Surg. Pathol. (2003) [Pubmed]
Metastatic placental site trophoblastic tumor: long-term remission in a patient treated with EMA/CO chemotherapy. Swisher, E., Drescher, C.W. Gynecol. Oncol. (1998) [Pubmed]
The expression and localization of neutral endopeptidase 24.11/CD10 in human gestational trophoblastic diseases. Ino, K., Suzuki, T., Uehara, C., Nagasaka, T., Okamoto, T., Kikkawa, F., Mizutani, S. Lab. Invest. (2000) [Pubmed]
P53 gene product and EGF-receptor are highly expressed in placental site trophoblastic tumor. Müller-Höcker, J., Obernitz, N., Johannes, A., Löhrs, U. Hum. Pathol. (1997) [Pubmed]
Placental site trophoblastic tumor: human placental lactogen and pregnancy-associated major basic protein as immunohistologic markers. Rhoton-Vlasak, A., Wagner, J.M., Rutgers, J.L., Baergen, R.N., Young, R.H., Roche, P.C., Plummer, T.B., Gleich, G.J. Hum. Pathol. (1998) [Pubmed]
Relaxation of imprinting in trophoblastic disease. Ariel, I., Lustig, O., Oyer, C.E., Elkin, M., Gonik, B., Rachmilewitz, J., Biran, H., Goshen, R., de Groot, N., Hochberg, A. Gynecol. Oncol. (1994) [Pubmed]
Expression of maspin in gestational trophoblastic disease. Li, H.W., Leung, S.W., Cheung, A.N., Yu, M.M., Chan, L.K., Wong, Y.F. Gynecol. Oncol. (2006) [Pubmed]
c-mos immunoreactivity aids in the diagnosis of gestational trophoblastic lesions. Xue, W.C., Khoo, U.S., Ngan, H.Y., Chan, K.Y., Ip, P.P., Tsao, S.W., Cheung, A.N. Int. J. Gynecol. Pathol. (2004) [Pubmed]

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