The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MOS  -  v-mos Moloney murine sarcoma viral...

Homo sapiens

Synonyms: Oocyte maturation factor mos, Proto-oncogene c-Mos, Proto-oncogene serine/threonine-protein kinase mos
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MOS

  • RESULTS: The principal meiotic regulator MOS was found to be significantly post-transcriptionally up-regulated after irradiation in p53 mutated but not p53 wild-type lymphoma cells [1].
  • The c-mos proto-oncogene is the cellular counterpart of the viral oncogene v-mos isolated from Moloney murine sarcoma virus [2].
  • The 5-kb allele of the MOS oncogene, previously proposed to be associated with breast cancer, was absent in these families, suggesting that polymorphism at this locus is not associated with inherited susceptibility [3].
  • PURPOSE: To estimate the duration of survival (S) of patients with metastatic osteosarcoma (MOS) at diagnosis treated with a multiagent, ifosfamide-containing chemotherapeutic and surgical regimen and to evaluate the toxicity of this regimen [4].
  • Hormone levels, quality of life (MOS Short-Form Health Survey), sexual function (International Index of Erectile Function), benign prostate hyperplasia severity (American Urological Association Symptom Index Score), prostate-specific antigen, and measures of safety were compared among groups [5].

Psychiatry related information on MOS

  • Functional status was assessed by questionnaires characterizing walking ability (Walking Impairment Questionnaire, WIQ), habitual physical activity level (Physical Activity Recall, PAR), and physical, social, and role functioning, well-being, and overall health (Medical Outcomes Study SF-20, MOS) [6].
  • The subscale, Mental Health, from the MOS SF-20 was used to assess affective well-being [7].
  • CONCLUSIONS: In general, the 5 translations of the MOS HIV had similar psychometric properties to those reported in the validation study for the original US English version of the MOS HIV [8].
  • Patient's self-assessment of QL was measured with the 36-item MOS Short Form (SF-36) [9].
  • In this last group, among patients with similar levels of symptom severity, organic perceived causes were related to a lower physical health sum score on the MOS Short Form, and psychosocial perceived causes were related to less severe depressive symptoms, assessed with the Hospital Anxiety and Depression Scale at 6 months [10].

High impact information on MOS

  • Mo-MSV DNA synthesized in vitro was found to induce morphological transformation of NIH-3T3 mouse fibroblasts upon transfection [11].
  • The genome of MSV was shown to retain approximately 0.13 kb from the 5' end of the MuLV env region, including sequences which span the point in the MuLV env mRNA [12].
  • When transformants derived by transfection with 5.8 kbp dsDNA were infected with Moloney murine leukemia virus (Mo-MLV) helper virus, Mo-MSV was rescued from a small portion of these cells, suggesting the establishment of the complete viral genome in these cells [11].
  • The foci had a morphology indistinguishable from that of Mo-MSV-induced foci, and the induced transformed phenotype was stable [11].
  • This DNA species has been purified by sedimentation of total in vitro synthesized Mo-MSV DNA through neutral sucrose gradients [11].

Chemical compound and disease context of MOS


Biological context of MOS


Anatomical context of MOS


Associations of MOS with chemical compounds

  • The organic solvent was then evaporated to dryness and the residue reconstituted in 100 microliters of mobile phase prior to injecting a 20 microliters aliquot onto a Hypersil 5 MOS column, which was eluted with acetonitrile/acetate buffer (pH 5.5) 36:64 vol/vol [20].
  • Ratings of current health and health free of angina using a verbal rating scale in which 0 = death and 100 = perfect health, the MOS SF-36, the Index of Coexistent Disease (a validated measure of comorbidity), and a question on the severity of anginal symptoms [21].
  • The MOS/ADR1 cells were found to exhibit cross-resistance only to substrates for P-glycoprotein (such as doxorubicin, vincristine, and etoposide), whereas the MOS/IR1 cells were resistant to all of the drugs studied (including cisplatin and methotrexate) [13].
  • The addition of a P-glycoprotein antagonist, verapamil, or the depletion of cellular adenosine triphosphate resulted in a marked increase in the accumulation of doxorubicin in the MOS/ADR1 cells (p < 0.05) but not in the MOS/ IR1 cells [13].
  • At baseline and follow-up (20 weeks), subjects completed a questionnaire that included the 20 item MOS Short-Form Health Survey, Multidimensional Health Locus of Control Scale, and Philadelphia Geriatric Center Morale Scale, and bone density was measured by dual energy X-ray absorptiometry [22].

Other interactions of MOS

  • ERK2 then acts back on MOS to enhance its expression and amplify the kinase signaling cascade [18].
  • Detailed signaling studies reveal that Paxillin is acting early in the kinase cascade, because it is required for accumulation of MOS protein and complete activation of downstream kinase signaling in response to steroids [18].
  • METHODS: We analysed the HRQL evolution over 5 years for 1,000 patients initiating a protease inhibitor (PI)-containing therapy, using MOS SF-36 physical (PCS) and mental (MCS) scores [23].
  • The transient expression of c-mos and high levels of cyclin-B1 mRNA suggest that mechanisms similar to those found in lower organisms govern the growth and development of the human oocyte and preimplantation embryo [19].
  • Since the long arm of chromosome 8 is frequently the site of increased gene copy number (ICN) in breast cancer, we screened 442 breast tumor DNAs for gains of E2F5, MOS, and MYC genes [24].

Analytical, diagnostic and therapeutic context of MOS

  • Mortality was registered and MOS 36 Short-Form Health Survey answered at baseline and after 3, 6 and 12 months [25].
  • A cross-sectional study was performed on the association between general health status, as determined by the MOS, with sleepiness, assessed using a standardized questionnaire [the Epworth sleepiness scale (ESS)] and the multiple sleep latency test (MSLT) [26].
  • The MOS 36 item short form health survey questionnaire (SF-36) is widely acknowledged as the gold standard generic measure of health status; few studies however have evaluated its use for clinical trials in multiple sclerosis [27].
  • RESULTS: TMLR patients scored significantly better compared to controls in the MOS SF-24 social functioning, energy, general health, and bodily pain domains, in the EuroQol usual activity domain and the EuroQol Visual Analogue Scale, and in the SAQ physical limitation, angina frequency and disease perception domains [28].
  • The MOS short-form general health survey. Reliability and validity in a patient population [29].


  1. Upregulation of meiosis-specific genes in lymphoma cell lines following genotoxic insult and induction of mitotic catastrophe. Kalejs, M., Ivanov, A., Plakhins, G., Cragg, M.S., Emzinsh, D., Illidge, T.M., Erenpreisa, J. BMC Cancer (2006) [Pubmed]
  2. Human proto-oncogene c-mos maps to 8q11. Caubet, J.F., Mathieu-Mahul, D., Bernheim, A., Larsen, C.J., Berger, R. EMBO J. (1985) [Pubmed]
  3. Oncogenes and human breast cancer. Hall, J.M., Zuppan, P.J., Anderson, L.A., Huey, B., Carter, C., King, M.C. Am. J. Hum. Genet. (1989) [Pubmed]
  4. Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group Study. Harris, M.B., Gieser, P., Goorin, A.M., Ayala, A., Shochat, S.J., Ferguson, W.S., Holbrook, T., Link, M.P. J. Clin. Oncol. (1998) [Pubmed]
  5. Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels. Leder, B.Z., Rohrer, J.L., Rubin, S.D., Gallo, J., Longcope, C. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  6. Exercise training improves functional status in patients with peripheral arterial disease. Regensteiner, J.G., Steiner, J.F., Hiatt, W.R. J. Vasc. Surg. (1996) [Pubmed]
  7. Psychological well-being in older adults suffering from chronic headache. Jelicic, M., Kempen, G.I., Passchier, J. Headache. (1998) [Pubmed]
  8. Reliability and validity of French, German, Italian, Dutch, and UK English translations of the Medical Outcomes Study HIV Health Survey. Scott-Lennox, J.A., Wu, A.W., Boyer, J.G., Ware, J.E. Medical care. (1999) [Pubmed]
  9. Physical symptoms and quality of life in patients on chronic dialysis: results of The Netherlands Cooperative Study on Adequacy of Dialysis (NECOSAD). Merkus, M.P., Jager, K.J., Dekker, F.W., de Haan, R.J., Boeschoten, E.W., Krediet, R.T. Nephrol. Dial. Transplant. (1999) [Pubmed]
  10. Somatization revisited: diagnosis and perceived causes of common mental disorders. Henningsen, P., Jakobsen, T., Schiltenwolf, M., Weiss, M.G. J. Nerv. Ment. Dis. (2005) [Pubmed]
  11. A defined subgenomic fragment of in vitro synthesized Moloney sarcoma virus DNA can induce cell transformation upon transfection. Andersson, P., Goldfarb, M.P., Weinberg, R.A. Cell (1979) [Pubmed]
  12. An MSV-specific subgenomic mRNA in MSV-transformed G8-124 cells. Donoghue, D.J., Sharp, P.A., Weinberg, R.A. Cell (1979) [Pubmed]
  13. Intrinsic resistance to chemotherapeutic agents in murine osteosarcoma cells. Takeshita, H., Kusuzaki, K., Ashihara, T., Gebhardt, M.C., Mankin, H.J., Hirasawa, Y. The Journal of bone and joint surgery. American volume. (2000) [Pubmed]
  14. Do health causal attributions and coping strategies act as moderators of quality of life in peritoneal dialysis patients? Pucheu, S., Consoli, S.M., D'Auzac, C., Français, P., Issad, B. Journal of psychosomatic research. (2004) [Pubmed]
  15. Health-related quality of life in older people using benzodiazepines: a cross-sectional study. Gelatti, U., Samani, F., Donato, F., Covolo, L., Mazzaglia, G., Cremaschini, F., Simon, G., Leggieri, G., Balestrieri, M. Annali di igiene : medicina preventiva e di comunit??. (2006) [Pubmed]
  16. Treatment of chronic low back pain with etoricoxib, a new cyclo-oxygenase-2 selective inhibitor: improvement in pain and disability--a randomized, placebo-controlled, 3-month trial. Birbara, C.A., Puopolo, A.D., Munoz, D.R., Sheldon, E.A., Mangione, A., Bohidar, N.R., Geba, G.P. The journal of pain : official journal of the American Pain Society. (2003) [Pubmed]
  17. 9-(2-Phosphonylmethoxyethyl)adenine (PMEA) effectively inhibits retrovirus replication in vitro and simian immunodeficiency virus infection in rhesus monkeys. Balzarini, J., Naesens, L., Slachmuylders, J., Niphuis, H., Rosenberg, I., Holý, A., Schellekens, H., De Clercq, E. AIDS (1991) [Pubmed]
  18. Paxillin Regulates Steroid-triggered Meiotic Resumption in Oocytes by Enhancing an All-or-None Positive Feedback Kinase Loop. Rasar, M., Defranco, D.B., Hammes, S.R. J. Biol. Chem. (2006) [Pubmed]
  19. Cell cycle genes c-mos and cyclin-B1 are expressed in a specific pattern in human oocytes and preimplantation embryos. Heikinheimo, O., Lanzendorf, S.E., Baka, S.G., Gibbons, W.E. Hum. Reprod. (1995) [Pubmed]
  20. Analysis of desmethylmethsuximide using high-performance liquid chromatography. Streete, J.M., Berry, D.J., Clarke, L.A., Newbery, J.E. Therapeutic drug monitoring. (1995) [Pubmed]
  21. Angina patients' ratings of current health and health without angina: associations with severity of angina and comorbidity. Chen, A.Y., Daley, J., Thibault, G.E. Medical decision making : an international journal of the Society for Medical Decision Making. (1996) [Pubmed]
  22. The effect of a weighted vest on perceived health status and bone density in older persons. Greendale, G.A., Hirsch, S.H., Hahn, T.J. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. (1993) [Pubmed]
  23. Health-related quality of life in HIV-1-infected patients on HAART: a five-years longitudinal analysis accounting for dropout in the APROCO-COPILOTE cohort (ANRS CO-8). Protopopescu, C., Marcellin, F., Spire, B., Préau, M., Verdon, R., Peyramond, D., Raffi, F., Chêne, G., Leport, C., Carrieri, M.P. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation (2007) [Pubmed]
  24. Human E2F5 gene is oncogenic in primary rodent cells and is amplified in human breast tumors. Polanowska, J., Le Cam, L., Orsetti, B., Vallés, H., Fabbrizio, E., Fajas, L., Taviaux, S., Theillet, C., Sardet, C. Genes Chromosomes Cancer (2000) [Pubmed]
  25. Continued symptomatic improvement three to five years after transmyocardial revascularization with CO(2) laser: a late clinical follow-up of the Norwegian Randomized trial with transmyocardial revascularization. Aaberge, L., Rootwelt, K., Blomhoff, S., Saatvedt, K., Abdelnoor, M., Forfang, K. J. Am. Coll. Cardiol. (2002) [Pubmed]
  26. Relationship between sleepiness and general health status. Briones, B., Adams, N., Strauss, M., Rosenberg, C., Whalen, C., Carskadon, M., Roebuck, T., Winters, M., Redline, S. Sleep. (1996) [Pubmed]
  27. Clinical appropriateness: a key factor in outcome measure selection: the 36 item short form health survey in multiple sclerosis. Freeman, J.A., Hobart, J.C., Langdon, D.W., Thompson, A.J. J. Neurol. Neurosurg. Psychiatr. (2000) [Pubmed]
  28. Improved quality of life after XeCl excimer transmyocardial laser revascularization: results of a randomized trial. Huikeshoven, M., van der Sloot, J.A., Tukkie, R., van Gemert, M.J., Tijssen, J.G., Beek, J.F. Lasers in surgery and medicine. (2003) [Pubmed]
  29. The MOS short-form general health survey. Reliability and validity in a patient population. Stewart, A.L., Hays, R.D., Ware, J.E. Medical care. (1988) [Pubmed]
WikiGenes - Universities