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Disease relevance of Inovirus


High impact information on Inovirus

  • Here, a method is presented for engineering filamentous bacteriophage to display cocaine-binding proteins on its surface that sequester cocaine in the brain [5].
  • The U1A domain responsible for binding to U1 small nuclear RNA was locally mutagenized and displayed as a combinatorial library on filamentous bacteriophage [6].
  • In addition to podoviruses T3 and T7, strand bias of recognition sequences for different type III DNA modification-restriction enzymes is also observed in the inoviruses M13, IKE and PF3 [7].
  • A human antibody library was displayed on the surface of filamentous bacteriophage and screened for binding to human interleukin-6 (IL-6) [8].
  • To identify proteins that may participate in the targeting or storage of this potent inhibitor, this report investigates the applicability of utilizing filamentous bacteriophages to display proteins expressed by cells containing a regulated secretory pathway and their enrichment based upon an interaction with PAI-1 [9].

Chemical compound and disease context of Inovirus


Biological context of Inovirus


Anatomical context of Inovirus


Gene context of Inovirus

  • tolA mutants of Escherichia coli K-12 release periplasmic proteins into the extracellular medium; they are sensitive to growth inhibitors such as cholic acid and tolerant to group A colicins and filamentous bacteriophage [21].
  • Engineering antibodies to obtain the desired therapeutic characteristics is most readily achieved using recombinant antibody technology, and we have taken the approach of immunizing mice to provide high-affinity anti-CEA single-chain Fv antibodies (sFvs) from filamentous bacteriophage libraries [22].
  • A tripartite fusion construct encoding the amino-terminal half of EcoRI endonuclease followed by amino acids 217-299 of the filamentous bacteriophage gene I protein (pI) attached to the enzymatic portion of alkaline phosphatase results in the production of two proteins [23].
  • The solution structure of the Tyr41-->His mutant of the single-stranded DNA binding protein encoded by gene V of the filamentous bacteriophage M13 [24].
  • The relations between the protein coats and DNAs of the four filamentous bacteriophages fd, Xf, Pf1, and Pf3 are considered [25].

Analytical, diagnostic and therapeutic context of Inovirus


  1. A strategy of exon shuffling for making large peptide repertoires displayed on filamentous bacteriophage. Fisch, I., Kontermann, R.E., Finnern, R., Hartley, O., Soler-Gonzalez, A.S., Griffiths, A.D., Winter, G. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Cloning and expression of the filamentous bacteriophage Pf1 major coat protein gene in Escherichia coli. Membrane protein processing and virus assembly. Rowitch, D.H., Perham, R.N. J. Mol. Biol. (1987) [Pubmed]
  3. NMR structure of the principal neutralizing determinant of HIV-1 displayed in filamentous bacteriophage coat protein. Jelinek, R., Terry, T.D., Gesell, J.J., Malik, P., Perham, R.N., Opella, S.J. J. Mol. Biol. (1997) [Pubmed]
  4. PilR enhances the sensitivity of Xanthomonas axonopodis pv. citri to the infection of filamentous bacteriophage Cf. Yang, Y.C., Chou, C.P., Kuo, T.T., Lin, S.H., Yang, M.K. Curr. Microbiol. (2004) [Pubmed]
  5. Treating cocaine addiction with viruses. Carrera, M.R., Kaufmann, G.F., Mee, J.M., Meijler, M.M., Koob, G.F., Janda, K.D. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  6. Analysis of RNA-binding proteins by in vitro genetic selection: identification of an amino acid residue important for locking U1A onto its RNA target. Laird-Offringa, I.A., Belasco, J.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  7. The significance of distance and orientation of restriction endonuclease recognition sites in viral DNA genomes. Krüger, D.H., Kupper, D., Meisel, A., Reuter, M., Schroeder, C. FEMS Microbiol. Rev. (1995) [Pubmed]
  8. Recombinant human single chain Fv antibodies recognizing human interleukin-6. Specific targeting of cytokine-secreting cells. Krebs, B., Griffin, H., Winter, G., Rose-John, S. J. Biol. Chem. (1998) [Pubmed]
  9. Purification of storage granule protein-23. A novel protein identified by phage display technology and interaction with type I plasminogen activator inhibitor. Lang, I.M., Chuang, T.L., Barbas, C.F., Schleef, R.R. J. Biol. Chem. (1996) [Pubmed]
  10. Structural mimicry and enhanced immunogenicity of peptide epitopes displayed on filamentous bacteriophage. The V3 loop of HIV-1 gp120. di Marzo Veronese, F., Willis, A.E., Boyer-Thompson, C., Appella, E., Perham, R.N. J. Mol. Biol. (1994) [Pubmed]
  11. Evolution of peptides that modulate the spectral qualities of bound, small-molecule fluorophores. Rozinov, M.N., Nolan, G.P. Chem. Biol. (1998) [Pubmed]
  12. C2, and unusual filamentous bacterial virus: protein sequence and conformation, DNA size and conformation, and nucleotide/subunit ratio. Kostrikis, L.G., Reisberg, S.A., Kim, H.Y., Shin, S., Day, L.A. Biochemistry (1995) [Pubmed]
  13. Structure and dynamics of bacteriophage IKe major coat protein in MPG micelles by solution NMR. Williams, K.A., Farrow, N.A., Deber, C.M., Kay, L.E. Biochemistry (1996) [Pubmed]
  14. Studies on the structure of filamentous bacteriophage fd. II. All-or-none disassembly in guanidine-HCl and sodium dodecyl sulfate. Ikehara, K., Utiyama, H., Kurata, M. Virology (1975) [Pubmed]
  15. Molecular structure of fd (f1, M13) filamentous bacteriophage refined with respect to X-ray fibre diffraction and solid-state NMR data supports specific models of phage assembly at the bacterial membrane. Marvin, D.A., Welsh, L.C., Symmons, M.F., Scott, W.R., Straus, S.K. J. Mol. Biol. (2006) [Pubmed]
  16. Sugar pucker and phosphodiester conformations in viral genomes of filamentous bacteriophages: fd, If1, IKe, Pf1, Xf, and Pf3. Thomas, G.J., Prescott, B., Opella, S.J., Day, L.A. Biochemistry (1988) [Pubmed]
  17. The putative single-stranded DNA-binding protein of the filamentous bacteriophage, Ifl. Amino acid sequence of the protein and structure of the gene. Carne, A., Hill, D.F., Stockwell, P.A., Hughes, G., Petersen, G.B. Proc. Biol. Sci. (1991) [Pubmed]
  18. fii, a bacterial locus required for filamentous phage infection and its relation to colicin-tolerant tolA and tolB. Sun, T.P., Webster, R.E. J. Bacteriol. (1986) [Pubmed]
  19. Isolation and characterization of a Tn5-induced tolQ mutant of Escherichia coli. Madrid, C., Badenas, C., Juárez, A. Can. J. Microbiol. (1994) [Pubmed]
  20. Escherichia coli tolQ mutants are resistant to filamentous bacteriophages that adsorb to the tips, not the shafts, of conjugative pili. Bradley, D.E., Whelan, J. J. Gen. Microbiol. (1989) [Pubmed]
  21. Isolation and characterization of extragenic suppressor mutants of the tolA-876 periplasmic-leaky allele in Escherichia coli K-12. Amouroux, C., Lazzaroni, J.C., Portalier, R. FEMS Microbiol. Lett. (1991) [Pubmed]
  22. Recombinant anti-carcinoembryonic antigen antibodies for targeting cancer. Chester, K.A., Mayer, A., Bhatia, J., Robson, L., Spencer, D.I., Cooke, S.P., Flynn, A.A., Sharma, S.K., Boxer, G., Pedley, R.B., Begent, R.H. Cancer Chemother. Pharmacol. (2000) [Pubmed]
  23. The membrane domain of a bacteriophage assembly protein. Transmembrane-directed proteolysis of a membrane-spanning fusion protein. Guy-Caffey, J.K., Webster, R.E. J. Biol. Chem. (1993) [Pubmed]
  24. The solution structure of the Tyr41-->His mutant of the single-stranded DNA binding protein encoded by gene V of the filamentous bacteriophage M13. Folkers, P.J., Nilges, M., Folmer, R.H., Konings, R.N., Hilbers, C.W. J. Mol. Biol. (1994) [Pubmed]
  25. DNA and protein lattice-lattice interactions in the filamentous bacteriophages. Marzec, C.J., Day, L.A. Biophys. J. (1983) [Pubmed]
  26. Recent advances for the treatment of cocaine abuse: central nervous system immunopharmacotherapy. Dickerson, T.J., Janda, K.D. The AAPS journal [electronic resource]. (2005) [Pubmed]
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